在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GNMT Antibody

  • 中文名稱:
    GNMT兔多克隆抗體
  • 貨號:
    CSB-PA931421
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: CSB-PA931421(GNMT Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    GNMT
  • 別名:
    EC 2.1.1.20 antibody; Epididymis secretory sperm binding protein Li 182mP antibody; Glycine N methyltransferase antibody; Glycine N-methyltransferase antibody; Gnmt antibody; GNMT_HUMAN antibody; HEL S 182mP antibody; OTTHUMP00000016412 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human GNMT
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
  • 基因功能參考文獻:
    1. Elevated GNMT protein expression is associated with pathogenesis of hepatocellular carcinoma. PMID: 28205209
    2. In men of European descent, the GNMT rs10948059 and short tandem repeat polymorphism 1 were associated with prostate cancer risk. PMID: 24800880
    3. GNMT is an androgen receptor-targeted gene with its functional androgen response element located at +19/+33 of the first exon. PMID: 23883094
    4. The studies identify GNMT as a direct transcriptional target of the AR. PMID: 23997240
    5. DNA hypermethylation plays an important role in the repression of GNMT in hepatocellular carcinoma (HCC), and loss of GNMT in human HCC could promote the establishment of aberrant DNA methylation patterns at specific gene promoters PMID: 23475283
    6. single-nucleotide polymorphisms in VEGF, IL-10 and GNMT genes might have a synergistic role in the development of Prostate cancer PMID: 22850906
    7. Report SNPs that are highly associated with hepatic GNMT protein expression and the coordinate regulation of MAT1A levels. PMID: 22807109
    8. GNMT plays important role in maintaining normal function of brain; lack of GNMT causes dysfunction of important signaling pathways and results in alterations of neurotransmitter secretion as well as changes in neuropsychological behavior. PMID: 22264868
    9. GNMT is a crucial regulator in cholesterol metabolism and in inflammation, and contributes to the pathogenesis of atherosclerosis. PMID: 22415010
    10. In conclusion, GNMT regulates hepatocellular carcinoma growth in part through interacting with DEPDC6/DEPTOR and modulating mTOR/raptor signaling pathway PMID: 22160218
    11. GNMT may represent a novel marker of malignant progression and poor prognosis in prostate cancer PMID: 21572396
    12. This study suggests that the glycine N-methyltransferase STRP1 phenotype could modulate urinary 1-hydroxypyrene and 8-hydroxy-2'-deoxyguanosine levels in coke-oven workers exposed to PAHs. PMID: 21691217
    13. investigation of role of GNMT in methyl group homeostasis in liver: GNMT affects transmethylation kinetics, SAM synthesis, and conservation of methyl groups by limiting homocysteine remethylation flux; possible role of GNMT inactivation in hepatoma PMID: 21411609
    14. compound heterzygotes in the gene that encodes GNMT have evidence of mild liver disease PMID: 11810299
    15. Results suggest that GNMT alteration may be an early event in hepatocellular carcinoma development and that GNMT could be a new tumor susceptibility gene for hepatocellular carcinoma. PMID: 12566309
    16. GNMT 1289 C-->T polymorphism influences plasma homocysteine and is responsive to folate intake. PMID: 16317120
    17. GNMT is destabilized by a mutation. PMID: 17660255
    18. Glycine N-methyltransferase is a favorable prognostic marker for human cholangiocarcinoma. PMID: 18624901
    19. GNMT is a tumor suppressor gene for liver cancer, and it is associated with gender disparity in liver cancer susceptibility as shown in humans and in mouse models PMID: 19035462
    20. A transgenic mouse model is used together with in vitro methods to study the ability of the GNMT transgene to block the cytotoxic or carcinogenic activity of aflatoxin B1, a known causal agent of human hepatocellular carcinoma. PMID: 19146867
    21. Study identified a GNMT transcriptional start site at the 14th position upstream of the ATG codon; results indicate binding of the nuclear factor-Y (NF-Y) transcription factor to the CCAAT box (-71/-67) of the GNMT gene. PMID: 19439180

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Glycine N-methyltransferase deficiency (GNMT deficiency)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Class I-like SAM-binding methyltransferase superfamily, Glycine N-methyltransferase family
  • 組織特異性:
    Abundant in liver.
  • 數據庫鏈接:

    HGNC: 4415

    OMIM: 606628

    KEGG: hsa:27232

    STRING: 9606.ENSP00000361894

    UniGene: Hs.144914



主站蜘蛛池模板: 国产成人一区二区三区影院动漫| 亚洲成a人片在线观看中文| 日韩成人一区二区三区在线观看| 丰满熟妇人妻中文字幕 | 欧美色综合天天久久综合精品| 俺也来俺也去俺也射| 亚洲精品无码一二区a片| 一本一道精品欧美中文字幕| 国内揄拍国内精品人妻| 欧美级特黄aaaaaa片| 国产美女裸身网站免费观看视频 | 女人被狂c到高潮视频网站| 在线人成免费视频69国产| 亚洲成a∧人片在线播放调教| 精品久久久久久久中文字幕| 东京热无码av一区二区| 在线播放五十路熟妇| 久久久久久亚洲精品成人| 久久人人97超碰超国产| 成人乱码一区二区三区av66| 丰满少妇熟乱xxxxx视频| 久久无码人妻一区二区三区| 天堂中文在线资源| 黄网站色成年片在线观看| 日韩欧美偷拍高跟鞋精品一区| 韩国精品视频一区二区在线播放 | 无码国内精品人妻少妇| 国产揄拍国产精品| 国产亚洲日韩在线aaaa| 极品少妇一区二区三区四区| 国精无码欧精品亚洲一区| 久久九九久精品国产| 久久亚洲中文无码咪咪爱| 日韩乱码人妻无码中文视频| 成年女人免费碰碰视频| 久久发布国产伦子伦精品| 成人无码潮喷在线观看| 国产成人啪精品视频网站午夜| 亚洲色精品aⅴ一区区三区| 亚洲一区二区三区av无码| 色 成人 亚洲|