在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. GJD2 Antibody

GJD2 Antibody

  • 中文名稱：
    GJD2兔多克隆抗體
  • 貨號：
    CSB-PA891536LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate
      All lanes: GJD2 antibody at 3.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 37 kDa
      Observed band size: 37 kDa
    • IHC image of CSB-PA891536LA01HU diluted at 1:500 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA891536LA01HU diluted at 1:500 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA891536LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) GJD2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    GJD2; GJA9; Gap junction delta-2 protein; Connexin-36; Cx36; Gap junction alpha-9 protein
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Gap junction delta-2 protein (99-197AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，GJD2 Antibody (CSB-PA891536LA01HU)，的標記方式是Non-conjugated。對于GJD2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA891536LB01HU GJD2 Antibody, HRP conjugated ELISA
    FITC CSB-PA891536LC01HU GJD2 Antibody, FITC conjugated
    Biotin CSB-PA891536LD01HU GJD2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 基因功能參考文獻：
    1. a possible contribution of connexin 36 to amyotrophic lateral sclerosis pathogenesis PMID: 29246791
    2. Our findings suggest that the stimulatory effect of hexanol and isoflurane on Cx36 gap junction conductance could be achieved by re-shuffling of the inter-subunit disulphide bond between C264 and C92 to the intra-subunit one between C264 and C87. PMID: 29298877
    3. Our studies have shown that the heritability of myopia makes 66.4% in Lithuania. We detected significant associations between the combinations of GJD2 CC and RASGRF1 GT and odds ratio of developing myopia. PMID: 29793445
    4. Study shows that human outer retina displays a diverse cohort of connexin 36 gap junctions that follows the general mammalian scheme and display a great functional diversity. PMID: 26173976
    5. Sparse punctate Cx36 expression was seen in the myenteric plexus in nerve trunks and some platelet-derived growth factor receptor-alpha-positive cell and interstitial cells of Cajal fibers in patients with Hirschsprung's disease. PMID: 27916369
    6. Genetic variants in ZC3H11B, RSPO1, and GJD2 are associated with susceptibility to the development of high myopia in a Han Chinese population. PMID: 26485405
    7. It was shown that the decreased level of the examined neuronal proteins was accompanied by the impaired coexpression of synaptophysin/neurofilaments and Cx36 in the series of astrocytomas--anaplastic astrocytomas--glioblastomas. PMID: 26226778
    8. In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2, and ACTC1 with pathological myopia. PMID: 23834555
    9. Three SNP alleles in BRD2, Cx-36, and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy. PMID: 23756480
    10. Cx36 GJs are highly cation-selective and should exhibit relatively low permeability to numerous vital negatively charged metabolites and high permeability to potassium ion, a major charge carrier in cell-cell communication. PMID: 22752717
    11. A polymorphism of Cx36 gene is associated to certain forms of human diabetes PMID: 22288100
    12. connexin genes Gjd2 coding for mCx36, Gjc1 coding for mCx45 and Gja10 coding for mCx57 in the mouse, a subset of 4 connexin genes, including the unique GJA9 (Cx59) and GJA10 (Cx62), could be detected at least as transcript isoforms in the human retina. PMID: 20979653
    13. Variations in GJD2 is associated with refractive errors and myopia. PMID: 20835239
    14. Mutations in the calcium-binding motifs of CDH23 and the 35delG mutation in GJB2 cause hearing loss in one family PMID: 12522556
    15. connexin 36 expression is regulated by the transcriptional repressor NRSF/REST PMID: 14565956
    16. 35delG mutation of the GJB2 gne is a risk for deafness PMID: 15083701
    17. Results of reporter gene analysis of Cx36 expression in transgenic mice suggest that Cx36 has functional roles not only in several types of neurons in the retina and central nervous system but also in excitable cells of the pancreas and adrenal gland. PMID: 15116387
    18. significant association between juvenile myoclonic epilepsy and a Polymorphism, Single Nucleotide within exon 2 of CX36. PMID: 15235036
    19. Intercellular coupling occurs between neuronal and microglial populations through Cx36 gap junctions; This has important implications for normal neural physiology and microglial responses in neuronopathology in the mammalian CNS. PMID: 16211561
    20. The present results provide confirmatory evidence for an allelic and genotypic association of the CX36 gene with juvenile myoclonic epilepsy. PMID: 16876983
    21. Beta cells are extensively coupled within pancreatic islets via exchanges of mostly positively charged molecules across Cx36 channels. PMID: 17828386
    22. The data show that Cx36 is a native protein of human pancreatic islets, which mediates the coupling of the insulin-producing beta-cells, and contributes to control beta-cell function by modulating gene expression. PMID: 19000992
    23. CaMKII and Cx36 were shown to be significantly colocalized in the inferior olive, a brainstem nucleus highly enriched in electrical synapses, indicating physical proximity of these proteins PMID: 19095792
    24. ZO-2 may serve to anchor regulatory proteins at gap junctions composed of Cx36. PMID: 19418635

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族：
    Connexin family, Delta-type subfamily
  • 組織特異性：
    Highly expressed in neurons.
  • 數據庫鏈接：

    HGNC: 19154

    OMIM: 607058

    KEGG: hsa:57369

    STRING: 9606.ENSP00000290374

    UniGene: Hs.283816



主站蜘蛛池模板： 国产性生大片免费观看性| 国产偷窥熟女精品视频| 国产a国产片国产| 把插八插露脸对白内射| av中文无码乱人伦在线观看| 国产男女免费完整视频在线| 一本色道无码道dvd在线观看| 日韩人妻中文无码一区二区三区| 无码专区—va亚洲v天堂麻豆| 国产av丝袜旗袍无码网站| 亚洲v国产v天堂a无码二区| 中国女人内射6xxxxx| 欧美精品免费观看二区| 4hu四虎永久在线影院| 国产一区二区三区影院| 久久国产劲爆∧v内射| 在线观看的av免费网站| 国产欧美日韩综合在线成| 欧美老妇交乱视频在线观看| 揄拍成人国产精品视频| 伊人中文字幕无码专区| 少妇av射精精品蜜桃专区| 国产微拍精品一区二区| 国产无遮挡乱子伦免费精品| 99久久99久久精品国产片| 亚洲一区二区三区四区| 亚洲乱码av中文一区二区软件| 国产精品国产三级国产av剧情| 国产麻传媒精品国产av| 国产成人综合一区人人| 国产一区二区三区四区五区加勒比 | 日本www网站色情乱码| 亚洲人成网站日本片| 亚洲国产av精品一区二区蜜芽| 青青草国产线观看| 无码免费无线观看在线视频| 内射少妇一区27p| 欧美性色黄大片手机版| 亚洲旡码欧美大片| 最近中文字幕免费大全在线| 久久99精品国产麻豆婷婷|