在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GJD2 Antibody, Biotin conjugated

  • 中文名稱:
    GJD2兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA891536LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GJD2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    GJD2; GJA9; Gap junction delta-2 protein; Connexin-36; Cx36; Gap junction alpha-9 protein
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Gap junction delta-2 protein (99-197AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 基因功能參考文獻:
    1. a possible contribution of connexin 36 to amyotrophic lateral sclerosis pathogenesis PMID: 29246791
    2. Our findings suggest that the stimulatory effect of hexanol and isoflurane on Cx36 gap junction conductance could be achieved by re-shuffling of the inter-subunit disulphide bond between C264 and C92 to the intra-subunit one between C264 and C87. PMID: 29298877
    3. Our studies have shown that the heritability of myopia makes 66.4% in Lithuania. We detected significant associations between the combinations of GJD2 CC and RASGRF1 GT and odds ratio of developing myopia. PMID: 29793445
    4. Study shows that human outer retina displays a diverse cohort of connexin 36 gap junctions that follows the general mammalian scheme and display a great functional diversity. PMID: 26173976
    5. Sparse punctate Cx36 expression was seen in the myenteric plexus in nerve trunks and some platelet-derived growth factor receptor-alpha-positive cell and interstitial cells of Cajal fibers in patients with Hirschsprung's disease. PMID: 27916369
    6. Genetic variants in ZC3H11B, RSPO1, and GJD2 are associated with susceptibility to the development of high myopia in a Han Chinese population. PMID: 26485405
    7. It was shown that the decreased level of the examined neuronal proteins was accompanied by the impaired coexpression of synaptophysin/neurofilaments and Cx36 in the series of astrocytomas--anaplastic astrocytomas--glioblastomas. PMID: 26226778
    8. In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2, and ACTC1 with pathological myopia. PMID: 23834555
    9. Three SNP alleles in BRD2, Cx-36, and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy. PMID: 23756480
    10. Cx36 GJs are highly cation-selective and should exhibit relatively low permeability to numerous vital negatively charged metabolites and high permeability to potassium ion, a major charge carrier in cell-cell communication. PMID: 22752717
    11. A polymorphism of Cx36 gene is associated to certain forms of human diabetes PMID: 22288100
    12. connexin genes Gjd2 coding for mCx36, Gjc1 coding for mCx45 and Gja10 coding for mCx57 in the mouse, a subset of 4 connexin genes, including the unique GJA9 (Cx59) and GJA10 (Cx62), could be detected at least as transcript isoforms in the human retina. PMID: 20979653
    13. Variations in GJD2 is associated with refractive errors and myopia. PMID: 20835239
    14. Mutations in the calcium-binding motifs of CDH23 and the 35delG mutation in GJB2 cause hearing loss in one family PMID: 12522556
    15. connexin 36 expression is regulated by the transcriptional repressor NRSF/REST PMID: 14565956
    16. 35delG mutation of the GJB2 gne is a risk for deafness PMID: 15083701
    17. Results of reporter gene analysis of Cx36 expression in transgenic mice suggest that Cx36 has functional roles not only in several types of neurons in the retina and central nervous system but also in excitable cells of the pancreas and adrenal gland. PMID: 15116387
    18. significant association between juvenile myoclonic epilepsy and a Polymorphism, Single Nucleotide within exon 2 of CX36. PMID: 15235036
    19. Intercellular coupling occurs between neuronal and microglial populations through Cx36 gap junctions; This has important implications for normal neural physiology and microglial responses in neuronopathology in the mammalian CNS. PMID: 16211561
    20. The present results provide confirmatory evidence for an allelic and genotypic association of the CX36 gene with juvenile myoclonic epilepsy. PMID: 16876983
    21. Beta cells are extensively coupled within pancreatic islets via exchanges of mostly positively charged molecules across Cx36 channels. PMID: 17828386
    22. The data show that Cx36 is a native protein of human pancreatic islets, which mediates the coupling of the insulin-producing beta-cells, and contributes to control beta-cell function by modulating gene expression. PMID: 19000992
    23. CaMKII and Cx36 were shown to be significantly colocalized in the inferior olive, a brainstem nucleus highly enriched in electrical synapses, indicating physical proximity of these proteins PMID: 19095792
    24. ZO-2 may serve to anchor regulatory proteins at gap junctions composed of Cx36. PMID: 19418635

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族:
    Connexin family, Delta-type subfamily
  • 組織特異性:
    Highly expressed in neurons.
  • 數據庫鏈接:

    HGNC: 19154

    OMIM: 607058

    KEGG: hsa:57369

    STRING: 9606.ENSP00000290374

    UniGene: Hs.283816



主站蜘蛛池模板: 国内精品视频一区二区八戒| 无码人妻丰满熟妇奶水区码| 少妇久久久久久被弄高潮| 伊伊人成亚洲综合人网7777| 97人妻人人做人碰人人爽| 国产高清狼人香蕉在线| 女人张开双腿让男人猛桶| 欧洲人免费视频网站在线| 蜜桃视频在线观看免费网址入口| 亚洲午夜久久久无码精品网红a片| 亚洲综合激情七月婷婷| 久久人妻少妇嫩草av| 久久综合亚洲色hezyo社区| 内射毛片内射国产夫妻| 日本边添边摸边做边爱喷水| 亚洲a∨精品永久无码| 久久久精品94久久精品| 日韩毛片免费无码无毒视频观看| 免费人妻av无码专区| 国产乱子经典视频在线观看| 国产综合有码无码视频在线| 人妻精品久久无码区| 可以免费观看的av毛片下载| 亚洲色成人中文字幕网站 | 国精产品一二三区精华液| 午夜精品久久久久久久久| 一本久久a久久免费精品不卡| 中国china体内裑精亚洲日本| 亚洲国产aⅴ综合网| 国产欧美亚洲精品a| 日韩超碰人人爽人人做人人添 | 成人免费网站视频www| 亚洲精品中国国产嫩草影院美女 | 免费看成人aa片无码视频吃奶| 荫蒂被男人添的好舒服爽免费视频| 丰满爆乳无码一区二区三区| 亚洲国产天堂久久久久久| 国产无遮挡又爽又黄的视频| 亚洲精品无码专区| 国产成人无码精品久久久免费 | 男女啪啪高潮无遮挡免费|