在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GJD2 Antibody, FITC conjugated

  • 中文名稱:
    GJD2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA891536LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GJD2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    GJD2; GJA9; Gap junction delta-2 protein; Connexin-36; Cx36; Gap junction alpha-9 protein
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Gap junction delta-2 protein (99-197AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
  • 基因功能參考文獻:
    1. a possible contribution of connexin 36 to amyotrophic lateral sclerosis pathogenesis PMID: 29246791
    2. Our findings suggest that the stimulatory effect of hexanol and isoflurane on Cx36 gap junction conductance could be achieved by re-shuffling of the inter-subunit disulphide bond between C264 and C92 to the intra-subunit one between C264 and C87. PMID: 29298877
    3. Our studies have shown that the heritability of myopia makes 66.4% in Lithuania. We detected significant associations between the combinations of GJD2 CC and RASGRF1 GT and odds ratio of developing myopia. PMID: 29793445
    4. Study shows that human outer retina displays a diverse cohort of connexin 36 gap junctions that follows the general mammalian scheme and display a great functional diversity. PMID: 26173976
    5. Sparse punctate Cx36 expression was seen in the myenteric plexus in nerve trunks and some platelet-derived growth factor receptor-alpha-positive cell and interstitial cells of Cajal fibers in patients with Hirschsprung's disease. PMID: 27916369
    6. Genetic variants in ZC3H11B, RSPO1, and GJD2 are associated with susceptibility to the development of high myopia in a Han Chinese population. PMID: 26485405
    7. It was shown that the decreased level of the examined neuronal proteins was accompanied by the impaired coexpression of synaptophysin/neurofilaments and Cx36 in the series of astrocytomas--anaplastic astrocytomas--glioblastomas. PMID: 26226778
    8. In this study, there was no association of the analyzed SNPs located in RASGRF1. GJD2, and ACTC1 with pathological myopia. PMID: 23834555
    9. Three SNP alleles in BRD2, Cx-36, and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy. PMID: 23756480
    10. Cx36 GJs are highly cation-selective and should exhibit relatively low permeability to numerous vital negatively charged metabolites and high permeability to potassium ion, a major charge carrier in cell-cell communication. PMID: 22752717
    11. A polymorphism of Cx36 gene is associated to certain forms of human diabetes PMID: 22288100
    12. connexin genes Gjd2 coding for mCx36, Gjc1 coding for mCx45 and Gja10 coding for mCx57 in the mouse, a subset of 4 connexin genes, including the unique GJA9 (Cx59) and GJA10 (Cx62), could be detected at least as transcript isoforms in the human retina. PMID: 20979653
    13. Variations in GJD2 is associated with refractive errors and myopia. PMID: 20835239
    14. Mutations in the calcium-binding motifs of CDH23 and the 35delG mutation in GJB2 cause hearing loss in one family PMID: 12522556
    15. connexin 36 expression is regulated by the transcriptional repressor NRSF/REST PMID: 14565956
    16. 35delG mutation of the GJB2 gne is a risk for deafness PMID: 15083701
    17. Results of reporter gene analysis of Cx36 expression in transgenic mice suggest that Cx36 has functional roles not only in several types of neurons in the retina and central nervous system but also in excitable cells of the pancreas and adrenal gland. PMID: 15116387
    18. significant association between juvenile myoclonic epilepsy and a Polymorphism, Single Nucleotide within exon 2 of CX36. PMID: 15235036
    19. Intercellular coupling occurs between neuronal and microglial populations through Cx36 gap junctions; This has important implications for normal neural physiology and microglial responses in neuronopathology in the mammalian CNS. PMID: 16211561
    20. The present results provide confirmatory evidence for an allelic and genotypic association of the CX36 gene with juvenile myoclonic epilepsy. PMID: 16876983
    21. Beta cells are extensively coupled within pancreatic islets via exchanges of mostly positively charged molecules across Cx36 channels. PMID: 17828386
    22. The data show that Cx36 is a native protein of human pancreatic islets, which mediates the coupling of the insulin-producing beta-cells, and contributes to control beta-cell function by modulating gene expression. PMID: 19000992
    23. CaMKII and Cx36 were shown to be significantly colocalized in the inferior olive, a brainstem nucleus highly enriched in electrical synapses, indicating physical proximity of these proteins PMID: 19095792
    24. ZO-2 may serve to anchor regulatory proteins at gap junctions composed of Cx36. PMID: 19418635

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
  • 蛋白家族:
    Connexin family, Delta-type subfamily
  • 組織特異性:
    Highly expressed in neurons.
  • 數據庫鏈接:

    HGNC: 19154

    OMIM: 607058

    KEGG: hsa:57369

    STRING: 9606.ENSP00000290374

    UniGene: Hs.283816



主站蜘蛛池模板: 茄子在线看片免费人成视频| 无码人妻av一二区二区三区| 红杏亚洲影院一区二区三区| 日本高清www午色夜在线视频 | av无码免费永久在线观看| 波多野结衣人妻| 欧美 丝袜 自拍 制服 另类| 色婷婷我要去我去也| 国产亚洲人成网站在线观看| 四虎永久在线精品免费一区二区| 无码区国产区在线播放| 欧美亚洲日韩国产网站| 在线视频免费无码专区| 已婚少妇美妙人妻系列| 色综合久久无码中文字幕| 久青草国产97香蕉在线影院| 思思久久精品一本到99热| 扒开双腿疯狂进出爽爽爽视频| 亚洲熟妇av乱码在线观看| 国产揉捏爆乳巨胸挤奶视频| 男人扒开女人双腿猛进免费视频| 无码熟妇人妻av在线电影| 性欧美大胆免费播放| 国产精品点击进入在线影院高清| 久久久精品人妻一区二区三区gv| 久久久久久久久蜜桃| 国产精品视频白浆免费视频| 伊人无码一区二区三区| 无码国产成人久久| 久久99精品久久久久久| 亚洲欧美色αv在线影视| 欧美成人形色生活片| av无码一区二区三区| 久久先锋男人av资源网站| 中文成人无码精品久久久动漫 | 欧美成人精品三级网站视频| 成人免费ā片在线观看| 各处沟厕大尺度偷拍女厕嘘嘘| 国产丰满乱子伦无码专区| 亚洲人色婷婷成人网站在线观看| 色综合久久无码中文字幕|