在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GALR1 Antibody

  • 中文名稱:
    GALR1兔多克隆抗體
  • 貨號:
    CSB-PA008578
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    GALR1; GALNR; GALNR1; Galanin receptor type 1; GAL1-R; GALR-1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human GALR1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
  • 基因功能參考文獻:
    1. High methylation of GALR1 is associated with head and neck cancer. PMID: 27027429
    2. Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. PMID: 27685843
    3. The MOR-Gal1R heteromer can explain previous results showing antagonistic galanin-opioid interactions and offers a new therapeutic target for the treatment of opioid use disorder PMID: 28007761
    4. GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis PMID: 26572146
    5. Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. PMID: 24706871
    6. GALR1 methylation is associated with endometrial cancer. PMID: 23727823
    7. Moreover, we have identified a novel role for the GalR1/galanin receptor-ligand axis in chemoresistance, providing evidence to support its further evaluation as a potential therapeutic target and biomarker in colorectal cancer . PMID: 22859720
    8. Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence. PMID: 21796100
    9. The results of this study suggested an association between variation at the GALR1 locus and baseline craving for tobacco in smokers seeking cessation treatment. PMID: 21430647
    10. it has been demonstrated that GalR1-5-HT1A receptors heteromerize. PMID: 20171159
    11. disregulation of galanin receptor 1 may lead to uncontrolled proliferation and neoplastic transformation PMID: 15767248
    12. The analyzed single nucleotide polymorphisms in GAL and GALR1 do not play major role in early onset obesity or dietary fat intake in obese children and adolescents. PMID: 15930442
    13. There was no effect of GALR1 on alcoholism risk. PMID: 17083333
    14. Data suggest that galanin stimulates cortisol secretion from human inner adrenocortical cells, acting through GAL-R1 coupled to the adenylate cyclase/PKA-dependent signaling cascade via a Ptx-sensitive Galpha protein. PMID: 17982695
    15. GalR1 is internalized via the clathrin-dependent, endocytic pathway and then, to a large extent, delivered to lysosomes for degradation through the lysosome-targeting signal YXXO PMID: 18385373
    16. GAL, coding for the neuropeptide galanin, and GALR1, a galanin receptor, were identified as candidate genes of oncogenesis in squamous cell carcinoma using a survey of parallel chromosomal alterations and gene expression studies in 10 SCC cell lines. PMID: 18973137
    17. GALR1 is a tumor suppressor gene in head and neck squamous cell carcinoma PMID: 19047085

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:

    HGNC: 4132

    OMIM: 600377

    KEGG: hsa:2587

    STRING: 9606.ENSP00000299727

    UniGene: Hs.272191



主站蜘蛛池模板: 欧美群交射精内射颜射潮喷| 少妇高潮无套内谢麻豆传| 亚洲人成电影综合网站色www| 少妇激情一区二区三区视频| 狠狠躁夜夜躁人人爽天天不卡| 日本一区二区三区免费更新不卡| 国产成人亚洲综合无码品善网| 爱情岛论坛网亚洲品质| 污污内射在线观看一区二区少妇| 极品粉嫩国产18尤物在线观看| 婷婷色综合视频在线观看| 亚洲愉拍99热成人精品热久久 | 99精品电影一区二区免费看| 99久久久无码国产精品古装| 久久精品国产99久久无毒不卡| 日日摸日日碰夜夜爽亚洲| 波多野结av衣东京热无码专区| 亚洲vs日韩vs欧美vs久久| 99久久精品国产一区二区 | 久久久久无码国产精品一区 | 国产制服丝袜亚洲高清| 国产69精品久久久久乱码韩国 | 18禁区美女免费观看网站| 亚洲精品1卡2卡三卡23卡| 成年性生交大片免费看| 国产精品亚洲片在线观看不卡| 无码被窝影院午夜看片爽爽jk | 琪琪午夜理论片福利在线观看| 亚洲a∨无码男人的天堂| 色老久久精品偷偷鲁| 久久免费视频精品在线| 果冻传媒18禁免费视频| 97人妻精品一区二区三区| 日日躁狠狠躁狠狠爱| 2021久久最新国产精品| 深夜福利视频在线播放 | 熟妇高潮一区二区三区| 亚洲大尺度无码无码专线一区| 亚洲国产欧美一区二区好看电影| 国产精品日本亚洲欧美| 99精品视频九九精品视频|