在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GALR1 Antibody, Biotin conjugated

  • 中文名稱:
    GALR1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA009223LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GALR1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    GALR1; GALNR; GALNR1; Galanin receptor type 1; GAL1-R; GALR-1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Galanin receptor type 1 protein (293-349AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
  • 基因功能參考文獻(xiàn):
    1. High methylation of GALR1 is associated with head and neck cancer. PMID: 27027429
    2. Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. PMID: 27685843
    3. The MOR-Gal1R heteromer can explain previous results showing antagonistic galanin-opioid interactions and offers a new therapeutic target for the treatment of opioid use disorder PMID: 28007761
    4. GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis PMID: 26572146
    5. Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. PMID: 24706871
    6. GALR1 methylation is associated with endometrial cancer. PMID: 23727823
    7. Moreover, we have identified a novel role for the GalR1/galanin receptor-ligand axis in chemoresistance, providing evidence to support its further evaluation as a potential therapeutic target and biomarker in colorectal cancer . PMID: 22859720
    8. Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence. PMID: 21796100
    9. The results of this study suggested an association between variation at the GALR1 locus and baseline craving for tobacco in smokers seeking cessation treatment. PMID: 21430647
    10. it has been demonstrated that GalR1-5-HT1A receptors heteromerize. PMID: 20171159
    11. disregulation of galanin receptor 1 may lead to uncontrolled proliferation and neoplastic transformation PMID: 15767248
    12. The analyzed single nucleotide polymorphisms in GAL and GALR1 do not play major role in early onset obesity or dietary fat intake in obese children and adolescents. PMID: 15930442
    13. There was no effect of GALR1 on alcoholism risk. PMID: 17083333
    14. Data suggest that galanin stimulates cortisol secretion from human inner adrenocortical cells, acting through GAL-R1 coupled to the adenylate cyclase/PKA-dependent signaling cascade via a Ptx-sensitive Galpha protein. PMID: 17982695
    15. GalR1 is internalized via the clathrin-dependent, endocytic pathway and then, to a large extent, delivered to lysosomes for degradation through the lysosome-targeting signal YXXO PMID: 18385373
    16. GAL, coding for the neuropeptide galanin, and GALR1, a galanin receptor, were identified as candidate genes of oncogenesis in squamous cell carcinoma using a survey of parallel chromosomal alterations and gene expression studies in 10 SCC cell lines. PMID: 18973137
    17. GALR1 is a tumor suppressor gene in head and neck squamous cell carcinoma PMID: 19047085

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4132

    OMIM: 600377

    KEGG: hsa:2587

    STRING: 9606.ENSP00000299727

    UniGene: Hs.272191



主站蜘蛛池模板: 欧美成人精品 一区二区三区| 国产成人8x人网站在线视频| 国产精品aⅴ视频在线播放| 天堂www中文资源| 国产精品人妻久久久久| 国产呻吟久久久久久久92| 久久综合五月丁香六月丁香| 精品无码国产自产拍在线观看蜜| 永久免费的av片在线电影网| 国产做爰又粗又大又爽动漫| 亚洲男人的天堂成人www| 中日韩精品视频在线观看| 亚洲精品天堂成人片av在线播放 | 国产av熟女一区二区三区| 成人亚洲精品久久久久软件| 欧美成人免费全部观看国产| 国产亚洲精品久久久ai换脸| 白丝爆浆18禁一区二区三区| 亚洲熟女少妇一区二区| 国产成人无码aⅴ片在线观看| 久久先锋男人av资源网站| 久久伊99综合婷婷久久伊| 色94色欧美sute亚洲线路一| 成人美女黄网站色大免费的| 女厕偷窥一区二区三区| 久久www免费人成_看片| 亚洲精品成人久久电影网| 成人亚洲a片v一区二区三区动漫| 日韩电影一区二区三区| 久久高清内射无套| 亚洲乱码卡一卡二卡| 免费床视频大全叫不停欧美| 欧美成人在线视频| 3p人妻少妇对白精彩视频| 99精品国产丝袜在线拍国语| 久久精品第九区免费观看| 亚洲国产成人乱码| 久久婷婷五月综合97色直播| 免费能直接看黄的视频| 狠狠做五月深爱婷婷伊人| 亚洲午夜无码av毛片久久|