在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GALR1 Antibody, Biotin conjugated

  • 中文名稱:
    GALR1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA009223LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) GALR1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    GALR1; GALNR; GALNR1; Galanin receptor type 1; GAL1-R; GALR-1
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Galanin receptor type 1 protein (293-349AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
  • 基因功能參考文獻(xiàn):
    1. High methylation of GALR1 is associated with head and neck cancer. PMID: 27027429
    2. Study provides evidence that GAL and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma. PMID: 27685843
    3. The MOR-Gal1R heteromer can explain previous results showing antagonistic galanin-opioid interactions and offers a new therapeutic target for the treatment of opioid use disorder PMID: 28007761
    4. GAL and its receptors, GALR1 and GALR2, play a role in head and neck squamous cell carcinoma tumorigenesis PMID: 26572146
    5. Variants in genes for galanin (GAL) and its receptors (GALR1, GALR2, GALR3), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events. PMID: 24706871
    6. GALR1 methylation is associated with endometrial cancer. PMID: 23727823
    7. Moreover, we have identified a novel role for the GalR1/galanin receptor-ligand axis in chemoresistance, providing evidence to support its further evaluation as a potential therapeutic target and biomarker in colorectal cancer . PMID: 22859720
    8. Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence. PMID: 21796100
    9. The results of this study suggested an association between variation at the GALR1 locus and baseline craving for tobacco in smokers seeking cessation treatment. PMID: 21430647
    10. it has been demonstrated that GalR1-5-HT1A receptors heteromerize. PMID: 20171159
    11. disregulation of galanin receptor 1 may lead to uncontrolled proliferation and neoplastic transformation PMID: 15767248
    12. The analyzed single nucleotide polymorphisms in GAL and GALR1 do not play major role in early onset obesity or dietary fat intake in obese children and adolescents. PMID: 15930442
    13. There was no effect of GALR1 on alcoholism risk. PMID: 17083333
    14. Data suggest that galanin stimulates cortisol secretion from human inner adrenocortical cells, acting through GAL-R1 coupled to the adenylate cyclase/PKA-dependent signaling cascade via a Ptx-sensitive Galpha protein. PMID: 17982695
    15. GalR1 is internalized via the clathrin-dependent, endocytic pathway and then, to a large extent, delivered to lysosomes for degradation through the lysosome-targeting signal YXXO PMID: 18385373
    16. GAL, coding for the neuropeptide galanin, and GALR1, a galanin receptor, were identified as candidate genes of oncogenesis in squamous cell carcinoma using a survey of parallel chromosomal alterations and gene expression studies in 10 SCC cell lines. PMID: 18973137
    17. GALR1 is a tumor suppressor gene in head and neck squamous cell carcinoma PMID: 19047085

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4132

    OMIM: 600377

    KEGG: hsa:2587

    STRING: 9606.ENSP00000299727

    UniGene: Hs.272191



主站蜘蛛池模板: 天天爽天天狠久久久综合麻豆| 日韩日韩日韩日韩日韩| 免费无码一区二区三区蜜桃大| 337p日本大胆欧久久| 成人国产精品秘片多多| 国精品无码一区二区三区左线 | 国产午夜精华无码网站| 50岁熟妇的呻吟声对白| 亚洲乱码一区二区三区在线观看| 日韩综合夜夜香内射| 青青草无码伊人久久| 欧洲专线一区二区三区| 免费无码毛片一区二区三区a片| 中国凸偷窥xxxx自由视频妇科| 日韩精品人妻系列一区二区三区| 极品少妇被弄得高潮不断| 永久免费不卡在线观看黄网站| 国产人妖乱国产精品人妖| 亚洲国产av无码精品无广告 | 久久九九av免费精品| 人妻护士在线波多野结衣| 日韩成人av无码一区二区三区| 成人动漫综合网| 日韩精品中文字幕无码专区| 亚洲女人色综合小说| 无码精品黑人一区二区三区| 无码av波多野结衣久久| 五月丁香综合缴情六月小说 | 中文字幕一区在线观看视频| 久久人妻av一区二区软件| 国产又色又爽又刺激视频| 影音先锋无码a∨男人资源站| 真人与拘做受免费视频一| 老熟妇仑乱视频一区二区| 国产蜜芽尤物在线一区| 国产午夜福利在线观看视频_| 中文字幕精品亚洲无线码二区| 四虎国产精品永久入口| 无码人妻精品一区二区三区久久| 亚洲一区av无码专区在线观看| 无码高潮少妇毛多水多水免费|