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  4. GALNT14 Antibody

GALNT14 Antibody

  • 中文名稱：
    GALNT14兔多克隆抗體
  • 貨號：
    CSB-PA009208GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    GALNT14
  • 別名：
    GalNAc T14 antibody; GalNAc-T14 antibody; Galnt14 antibody; GLT14_HUMAN antibody; Polypeptide GalNAc transferase 14 antibody; Polypeptide N acetylgalactosaminyltransferase 14 antibody; Polypeptide N-acetylgalactosaminyltransferase 14 antibody; pp GaNTase 14 antibody; pp-GaNTase 14 antibody; Protein UDP acetylgalactosaminyltransferase 14 antibody; Protein-UDP acetylgalactosaminyltransferase 14 antibody; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 14 antibody; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human GALNT14
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.
  • 基因功能參考文獻：
    1. Silencing of GALNT14 in osterix-overexpressed cells restored the decreased chemosensitivity. Conversely, overexpression of GALNT14 in osterix-knockdown cells abrogated the increased chemosensitivity in breast cancer cells. PMID: 29227978
    2. The analysis showed that the "TT" genotype was associated with unfavorable overall survival (OS, P = 0.009). PMID: 27124048
    3. miR-125a functions as tumor suppressor in ovarian cancer by targeting GALNT14. PMID: 27133078
    4. GALNT14 genotypes were significantly associated with clinical outcomes of transcatheter arterial chemoembolization. PMID: 26871639
    5. Expression of GalNAc-T14 or HOXB9 was strongly correlated with reduced recurrence-free survival in lung adenocarcinomas. PMID: 26544896
    6. Recurrence of mutation suggests GALNT14 as a novel gene potentially involved in neuroblastoma predisposition. PMID: 26309160
    7. GALNT14 stimulates MMP-2 expression. PMID: 24962947
    8. GALN14 genotype (rs9679162) was an effective predictor for therapeutic outcome in advanced hepatocellular carcinoma (HCC) patients treated by FMP chemotherapy. PMID: 23959947
    9. Studies demonstrate that IGFBP-3 and GalNAc-T14 are colocalized in MCF-7 cells, and confirmed the interaction between IGFBP-3 and GalNAc-T14; these results reveal a minimal region of GalNAc-T14 that was sufficiently bound to the full-length IGFBP-3. PMID: 22441125
    10. Results provide evidence that GalNAc-T14 may be a potential biomarker for breast cancer by immunohistochemistry. PMID: 20356418
    11. GALNT14 and FUT3/6 H-scores were significantly higher in non-small cell lung cancer cell lines sensitive to dulanermin and drozitumab versus resistant cell lines PMID: 20179215
    12. cloning and characterization; results provide evidence that pp-GalNAc-T14 is a new member of the pp-GalNAc-T family and suggest that it may be involved in the O-glycosylation in kidney PMID: 12507512
    13. The role of GalNAc-T14 as an intracellular mediator of the effects of IGFBP-3 need to be verified in future studies. PMID: 17434446
    14. GALNT14 may be involved in regulating the apoptotic action of IGFBP-3. PMID: 19805900

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  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 2 family, GalNAc-T subfamily
  • 組織特異性：
    Detected in renal tubules (at protein level). Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bl
  • 數(shù)據(jù)庫鏈接：

    HGNC: 22946

    OMIM: 608225

    KEGG: hsa:79623

    STRING: 9606.ENSP00000288988

    UniGene: Hs.468058



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