在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GABRB1 Antibody

  • 中文名稱:
    GABRB1兔多克隆抗體
  • 貨號:
    CSB-PA086437
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA086437(GABRB1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA086437(GABRB1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal brain tissue, Primary antibody: CSB-PA086437(GABRB1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AW061132 antibody; B230208N19Rik antibody; GABA(A) receptor beta 1 antibody; GABA(A) receptor subunit beta-1 antibody; GABA-A receptor; beta-1 polypeptide antibody; Gabrb-1 antibody; GABRB1 antibody; Gamma aminobutyric acid (GABA) A receptor beta 1 antibody; Gamma Aminobutyric Acid A Receptor Beta 1 antibody; Gamma Aminobutyric Acid Receptor ; beta-1 antibody; Gamma-aminobutyric acid (GABA) A receptor; subunit beta 1 antibody; Gamma-aminobutyric acid receptor subunit beta-1 antibody; GARB1 antibody; GBRB1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human GABRB1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
  • 基因功能參考文獻:
    1. No allelic association was detected in this study between tested SNPs and risk for developing alcohol dependence in a British and Irish population; however, modest genotypic associations were found with several intronic GABRbeta1 SNPs that may directly influence alcohol dependence risk or may be in linkage disequilibrium with causal risk variants in nearby genes, including other GABA receptor subunits PMID: 28346242
    2. Results from genome-wide DNA methylation, functional network analysis and pyrosequencing, show selective CpG sites (NOS1AP, BID, and GABRB1) differentially methylated in smokers and chronic obstructive pulmonary disease patients compared to nonsmokers. PMID: 28416970
    3. PCDHB14- and GABRB1-like nervous system developmental genes are altered during early neuronal differentiation of NCCIT cells treated with ethanol PMID: 25566775
    4. This study showed that in male group the expression of GABRB1 was generally lower in schizophrenia cases compared to the control, but was higher in female group. PMID: 25660468
    5. Both mRNA and protein of GABAB receptor subunits, GABAB1 and GABAB2, were co-expressed in cultured human RPE cells; GABAB receptors regulate the [Ca2+]i via a pertussis toxin-sensitive Gi/o-protein pathway and a phospholipase C pathway PMID: 25241062
    6. study provides the first evidence for the involvement of the GABRB1 gene in the thalamus structure and their interactive effects on intelligence PMID: 25192656
    7. This study demonstrates altered patterns of N-glycosylation of GABRB1 in the temporal lobe in schizophrenia. PMID: 23917429
    8. GABRB1 protein levels were significantly decreased in schizophrenia, major depressive disorder, and bipolar disorder patients' lateral cerebellum compared to controls. PMID: 24022508
    9. These results suggest that epigenetic control of gene expression may affect the expression of GABRB1 and disrupt inhibitory synaptic transmission during embryonic development. PMID: 23392927
    10. Gaba-A receptor subunit beta1 is not involved in amygdala hyperexcitability of patients with temporal lobe epilepsy. PMID: 20848605
    11. Gaba (A) beta1 and beta3 subunit mRNA levels in the dorsolateral prefrontal cortex are not altered in schizophrenia. PMID: 20843900
    12. linkage disequilibrium between beta frequency of EEG and a set of GABA(A) receptor genes PMID: 11891318
    13. A signal for GABA A beta 1 isoform mRNA transcript could not be detected in the competitive RT-PCR assay. PMID: 15337300
    14. histamine modulates heteromultimeric GABA(A) receptors and may thus represent an endogenous ligand for an allosteric site PMID: 18281286
    15. three distinct sets of amino acid residues in the N-terminal extracellular domain of the hbeta1 subunit, which when mutated to the homologous residue in hbeta3 allow expression as a functional homomeric receptor PMID: 18650446

    顯示更多

    收起更多

  • 相關疾病:
    Epileptic encephalopathy, early infantile, 45 (EIEE45)
  • 亞細胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRB1 sub-subfamily
  • 數據庫鏈接:

    HGNC: 4081

    OMIM: 137190

    KEGG: hsa:2560

    STRING: 9606.ENSP00000295454

    UniGene: Hs.254117



主站蜘蛛池模板: 亚洲理论在线a中文字幕| 欧美亚洲国产一区二区三区| 国产乱人伦精品一区二区| 青青爽无码视频在线观看| 国产 高清 无码 在线播放| 久久精品av一区二区免费| 苍井空一区二区波多野结衣av | 日日躁狠狠躁狠狠爱| 少妇被又大又粗又爽毛片| 日韩在线不卡免费视频一区| 97色伦图片97综合影院| 亚洲人成无码区在线观看| 韩国精品久久久久久无码| 少妇精品无码一区二区免费视频| 色播久久人人爽人人爽人人片av | 青青青国产在线视频在线观看| 天天爽夜夜爽视频精品| 中文字幕亚韩| 国产又色又爽又刺激视频| 久久99国产综合精品女同| 欧美另类精品xxxx| 久久99热人妻偷产国产| 日韩新无码精品毛片| 色悠久久久久综合先锋影音下载| 亚洲蜜桃精久久久久久久久久久久 | 日本大肚子孕妇交xxx| 国产午夜手机精彩视频| 欧美大肥婆大肥bbbbb| 99热精品国自产拍天天拍| 麻豆av久久av盛宴av| 狠狠色综合7777久夜色撩人ⅰ| 精品国产久九九| 无码人妻久久一区二区三区app | av狼友无码国产在线观看| 在线播放偷拍一区精品| 日本熟妇浓毛hdsex| 在线 | 麻豆国产传媒61国产免费| 国产97人妻人人做人碰人人爽| 小罗莉极品一线天在线| 国产精品国色综合久久| 亚洲2020天天堂在线观看 |