在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GABRB1 Antibody

  • 中文名稱:
    GABRB1兔多克隆抗體
  • 貨號(hào):
    CSB-PA554723
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA554723(GABRB1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA554723(GABRB1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AW061132 antibody; B230208N19Rik antibody; GABA(A) receptor beta 1 antibody; GABA(A) receptor subunit beta-1 antibody; GABA-A receptor; beta-1 polypeptide antibody; Gabrb-1 antibody; GABRB1 antibody; Gamma aminobutyric acid (GABA) A receptor beta 1 antibody; Gamma Aminobutyric Acid A Receptor Beta 1 antibody; Gamma Aminobutyric Acid Receptor ; beta-1 antibody; Gamma-aminobutyric acid (GABA) A receptor; subunit beta 1 antibody; Gamma-aminobutyric acid receptor subunit beta-1 antibody; GARB1 antibody; GBRB1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human GABRB1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
  • 基因功能參考文獻(xiàn):
    1. No allelic association was detected in this study between tested SNPs and risk for developing alcohol dependence in a British and Irish population; however, modest genotypic associations were found with several intronic GABRbeta1 SNPs that may directly influence alcohol dependence risk or may be in linkage disequilibrium with causal risk variants in nearby genes, including other GABA receptor subunits PMID: 28346242
    2. Results from genome-wide DNA methylation, functional network analysis and pyrosequencing, show selective CpG sites (NOS1AP, BID, and GABRB1) differentially methylated in smokers and chronic obstructive pulmonary disease patients compared to nonsmokers. PMID: 28416970
    3. PCDHB14- and GABRB1-like nervous system developmental genes are altered during early neuronal differentiation of NCCIT cells treated with ethanol PMID: 25566775
    4. This study showed that in male group the expression of GABRB1 was generally lower in schizophrenia cases compared to the control, but was higher in female group. PMID: 25660468
    5. Both mRNA and protein of GABAB receptor subunits, GABAB1 and GABAB2, were co-expressed in cultured human RPE cells; GABAB receptors regulate the [Ca2+]i via a pertussis toxin-sensitive Gi/o-protein pathway and a phospholipase C pathway PMID: 25241062
    6. study provides the first evidence for the involvement of the GABRB1 gene in the thalamus structure and their interactive effects on intelligence PMID: 25192656
    7. This study demonstrates altered patterns of N-glycosylation of GABRB1 in the temporal lobe in schizophrenia. PMID: 23917429
    8. GABRB1 protein levels were significantly decreased in schizophrenia, major depressive disorder, and bipolar disorder patients' lateral cerebellum compared to controls. PMID: 24022508
    9. These results suggest that epigenetic control of gene expression may affect the expression of GABRB1 and disrupt inhibitory synaptic transmission during embryonic development. PMID: 23392927
    10. Gaba-A receptor subunit beta1 is not involved in amygdala hyperexcitability of patients with temporal lobe epilepsy. PMID: 20848605
    11. Gaba (A) beta1 and beta3 subunit mRNA levels in the dorsolateral prefrontal cortex are not altered in schizophrenia. PMID: 20843900
    12. linkage disequilibrium between beta frequency of EEG and a set of GABA(A) receptor genes PMID: 11891318
    13. A signal for GABA A beta 1 isoform mRNA transcript could not be detected in the competitive RT-PCR assay. PMID: 15337300
    14. histamine modulates heteromultimeric GABA(A) receptors and may thus represent an endogenous ligand for an allosteric site PMID: 18281286
    15. three distinct sets of amino acid residues in the N-terminal extracellular domain of the hbeta1 subunit, which when mutated to the homologous residue in hbeta3 allow expression as a functional homomeric receptor PMID: 18650446

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Epileptic encephalopathy, early infantile, 45 (EIEE45)
  • 亞細(xì)胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRB1 sub-subfamily
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4081

    OMIM: 137190

    KEGG: hsa:2560

    STRING: 9606.ENSP00000295454

    UniGene: Hs.254117



主站蜘蛛池模板: 就去干成人网| 西西人体大胆扒开下部337卩| 久久www成人片免费看| 国产卡一卡二无线乱码| 在线看片人成视频免费无遮挡| 西西444www无码大胆| 超级碰97直线国产免费公开| 国产亚洲日韩在线a不卡| 日本熟妇人妻xxxx| 黄页网站视频| 国厂精品114福利电影免费| 色优久久久久综合网鬼色| 国产av国片精品| 丰满人妻被公侵犯高清版| 成人亚洲欧美日韩在线观看| 亚洲成在人线免费观看| 久热这里在线精品| 国产交换配乱婬视频| 欧美性插b在线视频网站| 最近免费中文字幕大全免费版视频| 18禁区美女免费观看网站| 欧美xxxx黑人又粗又长| 成人精品一区二区三区电影| 天天做天天大爽天天爱| 色综合a怡红院怡红院| 女人高潮抽搐喷液30分钟视频| 欧美性xxxx极品少妇| 曰本一道本久久88不卡| 国产亚洲曝欧美不卡精品| 亚洲精品一区二区久| 国产玉足脚交极品在线播放| 国产精品日本亚洲777| 麻豆av一区二区三区| 在线视频夫妻内射| 人妻出差精油按摩被中出| 欧美成人一区二区三区在线观看| 香蕉av福利精品导航| 亚洲国产精品无码7777一线| 亚洲午夜福利在线视频| 国产自产v一区二区三区c| 2020每日更新国产精品视频|