在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FOSL2 Antibody

  • 中文名稱:
    FOSL2兔多克隆抗體
  • 貨號:
    CSB-PA008793ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA008793ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA008793ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FOSL2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    FLJ23306 antibody; Fos L2 antibody; FOS like antigen 2 antibody; Fos related antigen 2 antibody; Fos-related antigen 2 antibody; FosL 2 antibody; Fosl2 antibody; FOSL2_HUMAN antibody; FRA 2 antibody; FRA-2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Fos-related antigen 2 protein (187-326AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
  • 基因功能參考文獻:
    1. this study indicates the existence of an aberrant miR-124-3p/Fra-2 pathway that results in glioma aggressiveness PMID: 30243808
    2. Data provide evidence that FOSL2 is the target gene of miR-143 and negatively correlated with its expression. Down-regulation of FOSL2 seems to be a critical step in regulation of OS properties and the expression of miR-143 can inhibit the proliferation, migration and invasion of OS by reducing the expression of FOSL2. PMID: 29330462
    3. FOSL2 is a direct target of miR-597 in breast cancer cells. PMID: 28393251
    4. The binding and expression of c-Fos/Fra-2 increased as a function of severity of tongue lesions, yet selective participation of c-Jun appears to promote poor differentiation and aggressive tumorigenesis. PMID: 26581505
    5. FOSL2 facilitates TGF-beta1-induced migration by interaction with Smad3 in non-small cell lung cancer.FOSL2 positively regulates TGF-beta1 signalling . PMID: 25375657
    6. FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells. PMID: 24587342
    7. we show that the suppression was mediated, at least in part, by a suspension culture-driven decrease in the levels of two members of the AP1 transcription factor complex, c-Jun and Fra2 PMID: 23339184
    8. SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma. PMID: 23482931
    9. This study suggests that Fra-2 transgenic mice as an animal model of systemic sclerosis-associated pulmonary arterial hypertension display main characteristic features of the human disease. PMID: 22523431
    10. results demonstrate the presence of a common oncogenic cascade initiated by FRA2/JUND in CCR4-expressing mature T-cell malignancies such as ATLL and CTCLs PMID: 22493372
    11. FOSL2 is a critical regulator of leptin expression in adipocytes PMID: 22326952
    12. Results suggest that Fra-2 protein may be more effective than ATF-2 protein in cyst formation originated from epithelial cells of dental follicles. PMID: 20675274
    13. These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans. PMID: 20837772
    14. Fra-2 is overexpressed in SSc and acts as a novel downstream mediator of the profibrotic effects of TGFbeta and PDGF. PMID: 20039427
    15. Fra-2 overexpression is associated with a more aggressive tumor phenotype and is probably involved in breast cancer progression in vivo. PMID: 17393299
    16. aberrantly expressed Fra-2 in association with JunD may play a major role in CCR4 expression and oncogenesis in adult T-cell leukemia. PMID: 18071306
    17. Genes for Fra2, Id2, and CSF1-receptor are deregulated, regardless of whether the in anaplastic large cell lymphoma contains the t(2;5). PMID: 19321746
    18. Fra-2 transgenic natural killer (NK)T cells produce unusually high amounts of interleukin (IL)-2 and IL-4, and proliferate abnormally. PMID: 19620306
    19. Fra-2 is present in human systemic sclerosis and may contribute to the development of microvasculopathy by inducing endothelial cell apoptosis and by reducing endothelial cell migration and chemotaxis. PMID: 19933934

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    BZIP family, Fos subfamily
  • 數據庫鏈接:

    HGNC: 3798

    OMIM: 601575

    KEGG: hsa:2355

    STRING: 9606.ENSP00000264716

    UniGene: Hs.220971



主站蜘蛛池模板: 男女无遮挡xx00动态图120秒| 亚洲中文无码av永久伊人| 国产国产裸模裸模私拍视频| 国产精品涩涩涩视频网站| 欧美大浪妇猛交饥渴大叫| 任你干视频精品播放| 日韩国产亚洲高清在线久草| 大胆欧美熟妇xx| yw尤物av无码国产在线观看| 国产片精品av在线观看夜色| 无码av无码天堂资源网影音先锋| 久久国产色av| 日韩精品人妻系列无码专区| 四房播色综合久久婷婷| 日日日日做夜夜夜夜无码| 中文成人无字幕乱码精品区| 99精品无码一区二区| 亚洲精品国产品国语原创| 亚洲成 人 综合 亚洲欧洲| 中文字幕人乱码中文字幕| 先锋影音xfyy5566男人资源| 免费无码作爱视频| 无码一区二区三区久久精品| 狼色精品人妻在线视频| 女人爽到喷水的视频大全| 亚洲一二区制服无码中字 | 99爱在线精品视频免费观看| 男人用嘴添女人下身免费视频| 久久无码av三级| 国产在线精品一区二区三区直播| 国产作爱激烈叫床视频| 色拍拍欧美视频在线看| 国产精品欧美福利久久| 人妻人人看人妻人人添| 亚洲风情亚aⅴ在线发布| 色资源av中文无码先锋| 亚洲国产成人精品无码区宅男| 国产人妻大战黑人20p| 亚洲国产成人久久一区二区三区| 国产成人无码午夜福利在线直播 | 人人妻人人澡人人爽秒播|