在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FGF13 Antibody

  • 中文名稱:
    FGF13兔多克隆抗體
  • 貨號:
    CSB-PA008619ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA008619ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FGF13 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FGF13
  • 別名:
    FGF 13 antibody; FGF 2 antibody; FGF-13 antibody; FGF13 antibody; FGF13_HUMAN antibody; FGF2 antibody; FHF 2 antibody; FHF-2 antibody; FHF2 antibody; Fibroblast growth factor 13 antibody; Fibroblast growth factor homologous factor 2 antibody; OTTHUMP00000024143 antibody; OTTHUMP00000024144 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Fibroblast growth factor 13 protein (1-245AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons.
  • 基因功能參考文獻:
    1. The present study reported the presence of FGF13 in the follicular fluid of women undergoing IVF/ICSI. Moreover, the relationships between FF-FGF13 and FF-TT, ovarian morphology and oocyte developmental competence imply that FF-FGF13 might be involved in the pathophysiological process of polycystic ovary syndrome. PMID: 30257687
    2. Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors PMID: 27916441
    3. FGF13 was downregulated in human placentae with early-onset preeclampsia. FGF13 played an important role in maintaining placental trophoblast permeability via the modulation of E-cadherin. PMID: 29405966
    4. We propose that, in cells in which activated oncogenes drive excessive protein synthesis, FGF13 may favor survival by maintaining translation rates at a level compatible with the protein quality-control capacity of the cell. Thus, FGF13 may serve as an enabler, allowing cancer cells to evade proteostasis stress triggered by oncogene activation. PMID: 27994142
    5. Study screened the coding and splice site regions of the FGF13 gene in a sample of 45 unrelated probands where genetic epilepsy with febrile seizures plus segregated in an X-linked pattern; subsequently identified a de novo FGF13 missense variant in an additional patient with febrile seizures and facial edema. Results suggest that FGF13 is not a common cause of genetic epilepsy with febrile seizures plus. PMID: 27810516
    6. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts. PMID: 28882890
    7. These data showed the diversity of the roles of the FGF13 N-termini in NaV1.5 channel modulation and suggested the importance of isoform-specific regulation PMID: 27246624
    8. the FGF13/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals PMID: 28162808
    9. for PCa patients after RP, FGF13 serves as a potential novel prognostic marker that improves prediction of BCR-free survival, in particular if combined with other clinical parameters. PMID: 26891277
    10. The findings of this study reveal a novel cause of this syndrome and underscore the powerful role of FGF13 in control of neuronal excitability. PMID: 26063919
    11. X-chromosome deletions may be a cause of WS with larger deletions being lethal to males and that FGF13 mutations may be a cause of Wildervanck Syndrome (WS). PMID: 23373430
    12. Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells PMID: 24113164
    13. FGF13 has a role in hair follicle growth and in the hair cycle as shown in a family with X-linked congenital generalized hypertrichosis PMID: 23603273
    14. interactions with perlecans PMID: 11847221
    15. identification of a domain controlling angiogenic properties PMID: 12496262
    16. FHF2B is an interacting partner of Na(v)1.6. The preferential expression of FHF2B in sensory neurons may provide a basis for physiological differences in sodium currents that have been reported at the nodes of Ranvier in sensory versus motor axons. PMID: 15282281

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell projection, filopodium. Cell projection, growth cone. Cell projection, dendrite. Nucleus. Cytoplasm.; [Isoform 1]: Nucleus, nucleolus.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族:
    Heparin-binding growth factors family
  • 組織特異性:
    Ubiquitously expressed. Predominantly expressed in the nervous system.
  • 數據庫鏈接:

    HGNC: 3670

    OMIM: 300070

    KEGG: hsa:2258

    STRING: 9606.ENSP00000359635

    UniGene: Hs.6540



主站蜘蛛池模板: 亚洲乱亚洲乱妇中文影视| 国产乱人伦av麻豆网| 美女裸体跪姿扒开屁股无内裤| 人妻熟女 视频二区 视频一区| 国产成人a∨麻豆精品| 日韩人妻中文无码一区二区三区| 亚洲精品永久在线观看| 成年女人免费v片| 国产69精品久久久久乱码| 国产高清乱理伦片中文小说 | 国产无遮挡18禁无码网站免费| 亚洲а∨天堂久久精品2021| 国产未发育呦交视频| 免费做a爰片久久毛片a片下载| 18禁午夜宅男成年网站| 内射口爆少妇麻豆| 亚洲精品第一国产综合精品| 97色偷偷色噜噜男人的天堂 | 真实的国产乱xxxx在线| 9420免费高清在线观看视频| 在线精品亚洲一区二区| 亚洲第一页综合图片自拍| 日本午夜免费福利视频| 亚洲欧美另类成人综合图片| 精品三级久久久久电影网| 国产成人精品一区二区在线小狼 | 热re99久久6国产精品免费| 亚洲视频一区| 一边摸一边做爽的视频17国产| 99久久免费国产精品四虎| 一区二区三区无码免费看| 亚洲午夜福利在线观看| 精品蜜臀av在线天堂| 无码专区丰满人妻斩六十路| 欧美性色19p| 久久久综合香蕉尹人综合网| 国产精品亚洲综合色区| 无码免费一区二区三区| 香蕉久久久久久久av网站| 日本成本人三级在线观看| 中文字幕人妻丝袜二区|