在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FGF13 Antibody

  • 中文名稱:
    FGF13兔多克隆抗體
  • 貨號:
    CSB-PA008619ESR1HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Fibroblast growth factor 13 antibody at 3μg/ml + Rat brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 28, 22, 29, 23, 26 kDa
      Observed band size: 28 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA008619ESR1HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) FGF13 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FGF13
  • 別名:
    FGF 13 antibody; FGF 2 antibody; FGF-13 antibody; FGF13 antibody; FGF13_HUMAN antibody; FGF2 antibody; FHF 2 antibody; FHF-2 antibody; FHF2 antibody; Fibroblast growth factor 13 antibody; Fibroblast growth factor homologous factor 2 antibody; OTTHUMP00000024143 antibody; OTTHUMP00000024144 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Rat
  • 免疫原:
    Recombinant Human Fibroblast growth factor 13 protein (1-245AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons.
  • 基因功能參考文獻(xiàn):
    1. The present study reported the presence of FGF13 in the follicular fluid of women undergoing IVF/ICSI. Moreover, the relationships between FF-FGF13 and FF-TT, ovarian morphology and oocyte developmental competence imply that FF-FGF13 might be involved in the pathophysiological process of polycystic ovary syndrome. PMID: 30257687
    2. Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors PMID: 27916441
    3. FGF13 was downregulated in human placentae with early-onset preeclampsia. FGF13 played an important role in maintaining placental trophoblast permeability via the modulation of E-cadherin. PMID: 29405966
    4. We propose that, in cells in which activated oncogenes drive excessive protein synthesis, FGF13 may favor survival by maintaining translation rates at a level compatible with the protein quality-control capacity of the cell. Thus, FGF13 may serve as an enabler, allowing cancer cells to evade proteostasis stress triggered by oncogene activation. PMID: 27994142
    5. Study screened the coding and splice site regions of the FGF13 gene in a sample of 45 unrelated probands where genetic epilepsy with febrile seizures plus segregated in an X-linked pattern; subsequently identified a de novo FGF13 missense variant in an additional patient with febrile seizures and facial edema. Results suggest that FGF13 is not a common cause of genetic epilepsy with febrile seizures plus. PMID: 27810516
    6. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts. PMID: 28882890
    7. These data showed the diversity of the roles of the FGF13 N-termini in NaV1.5 channel modulation and suggested the importance of isoform-specific regulation PMID: 27246624
    8. the FGF13/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals PMID: 28162808
    9. for PCa patients after RP, FGF13 serves as a potential novel prognostic marker that improves prediction of BCR-free survival, in particular if combined with other clinical parameters. PMID: 26891277
    10. The findings of this study reveal a novel cause of this syndrome and underscore the powerful role of FGF13 in control of neuronal excitability. PMID: 26063919
    11. X-chromosome deletions may be a cause of WS with larger deletions being lethal to males and that FGF13 mutations may be a cause of Wildervanck Syndrome (WS). PMID: 23373430
    12. Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells PMID: 24113164
    13. FGF13 has a role in hair follicle growth and in the hair cycle as shown in a family with X-linked congenital generalized hypertrichosis PMID: 23603273
    14. interactions with perlecans PMID: 11847221
    15. identification of a domain controlling angiogenic properties PMID: 12496262
    16. FHF2B is an interacting partner of Na(v)1.6. The preferential expression of FHF2B in sensory neurons may provide a basis for physiological differences in sodium currents that have been reported at the nodes of Ranvier in sensory versus motor axons. PMID: 15282281

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell projection, filopodium. Cell projection, growth cone. Cell projection, dendrite. Nucleus. Cytoplasm.; [Isoform 1]: Nucleus, nucleolus.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族:
    Heparin-binding growth factors family
  • 組織特異性:
    Ubiquitously expressed. Predominantly expressed in the nervous system.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3670

    OMIM: 300070

    KEGG: hsa:2258

    STRING: 9606.ENSP00000359635

    UniGene: Hs.6540



主站蜘蛛池模板: 亚洲国产长腿丝袜av天堂| 亚洲午夜成人精品无码| 久久99精品久久久久久不卡| 影音先锋女人av鲁色资源网久久| 国产99在线 | 中文| 成 人 色综合 综合网站| 青椒国产97在线熟女| 国产精品毛多多水多| 成人性做爰片免费视频| 国产精品成人免费999| 无码人妻久久1区2区3区| 成人免费无码大片a毛片抽搐| 久久天天躁夜夜躁狠狠85麻豆| 亚洲另类无码专区国内精品| 中文字幕无码热在线视频| 欧美自拍另类欧美综合图片区| 8x8ⅹ在线永久免费入口| 国内裸体无遮挡免费视频| 成年女人片免费视频播放a| 最近中文av字幕在线中文| 艳妇乳肉豪妇荡乳av无码福利| 中出あ人妻熟女中文字幕| 国产精品亚洲二区在线看 | 亚洲色婷婷一区二区三区| 国产av人人夜夜澡人人爽| 国产农村毛卡片| 国产偷窥熟女精品视频| 亚洲a成人片在线观看 | 蜜臀av综合网| 东京热人妻丝袜无码av一二三区观| 少妇的肉体aa片免费| 高潮又爽又无遮挡又免费| 久久成人国产精品无码| 中日韩精品视频在线观看| 丰满人妻熟妇乱又伦精品视| 野外少妇被弄到喷水在线观看| 亚洲国产欧美中文丝袜日韩| 久久婷婷五月综合97色一本一本 | 国产草莓视频无码a在线观看| 精品国内在视频线2019| 欧美两根一起进3p做受视频|