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Human fibroblast growth factor-13,FGF-13 ELISA Kit

  • 中文名稱:
    人成纖維細(xì)胞生長因子13(FGF-13)酶聯(lián)免疫試劑盒
  • 貨號:
    CSB-E13849h
  • 規(guī)格:
    96T/48T
  • 價(jià)格:
    ¥3600/¥2500
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    人成纖維細(xì)胞生長因子13(FGF-13)酶聯(lián)免疫試劑盒(CSB-E13849h)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織培養(yǎng)上清液樣本中的FGF13含量。FGF13 即成纖維細(xì)胞生長因子 13,在人體發(fā)育與疾病發(fā)生機(jī)制中扮演關(guān)鍵角色。研究發(fā)現(xiàn),它通過參與細(xì)胞增殖、分化和遷移等過程影響生理病理狀態(tài),和神經(jīng)系統(tǒng)發(fā)育、腫瘤發(fā)展等密切相關(guān),是極具潛力的藥物研發(fā)靶點(diǎn)。試劑盒檢測范圍為12.5 pg/mL-800 pg/mL,適用于神經(jīng)生物學(xué)、細(xì)胞信號傳導(dǎo)機(jī)制研究等科研場景,支持體外培養(yǎng)細(xì)胞模型中FGF - 13分泌水平的動(dòng)態(tài)監(jiān)測,或生物體液樣本的定量分析,為探索FGF - 13在神經(jīng)退行性疾病、發(fā)育異常等領(lǐng)域的生物學(xué)功能提供可靠工具。本品僅用于科研,不用于臨床診斷,產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名:
    FGF 13 ELISA Kit; FGF 2 ELISA Kit; FGF-13 ELISA Kit; FGF13 ELISA Kit; FGF13_HUMAN ELISA Kit; FGF2 ELISA Kit; FHF 2 ELISA Kit; FHF-2 ELISA Kit; FHF2 ELISA Kit; Fibroblast growth factor 13 ELISA Kit; Fibroblast growth factor homologous factor 2 ELISA Kit; OTTHUMP00000024143 ELISA Kit; OTTHUMP00000024144 ELISA Kit
  • 縮寫:
    FGF13
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 樣本類型:
    serum, plasma, cell culture supernates
  • 檢測范圍:
    12.5 pg/mL-800 pg/mL
  • 靈敏度:
    3.12 pg/mL
  • 反應(yīng)時(shí)間:
    1-5h
  • 樣本體積:
    50-100ul
  • 檢測波長:
    450 nm
  • 研究領(lǐng)域:
    Signal Transduction
  • 測定原理:
    quantitative
  • 測定方法:
    Sandwich
  • 精密度:
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度:
    To assess the linearity of the assay, samples were spiked with high concentrations of human FGF-13 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
      Sample Serum(n=4)
    1:1 Average % 85
    Range % 80-90
    1:2 Average % 96
    Range % 92-100
    1:4 Average % 90
    Range % 85-94
    1:8 Average % 92
    Range % 88-96
  • 回收率:
    The recovery of human FGF-13 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample Type Average % Recovery Range
    Serum (n=5) 88 84-92
    EDTA plasma (n=4) 104 100-109
  • 標(biāo)準(zhǔn)曲線:
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    pg/ml OD1 OD2 Average Corrected
    800 2.152 2.263 2.208 2.062
    400 1.607 1.712 1.660 1.514
    200 1.179 1.096 1.138 0.992
    100 0.781 0.745 0.763 0.617
    50 0.435 0.451 0.443 0.297
    25 0.314 0.307 0.311 0.165
    12.5 0.228 0.234 0.231 0.085
    0 0.143 0.149 0.146  
  • 數(shù)據(jù)處理:
  • 貨期:
    3-5 working days

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons.
  • 基因功能參考文獻(xiàn):
    1. The present study reported the presence of FGF13 in the follicular fluid of women undergoing IVF/ICSI. Moreover, the relationships between FF-FGF13 and FF-TT, ovarian morphology and oocyte developmental competence imply that FF-FGF13 might be involved in the pathophysiological process of polycystic ovary syndrome. PMID: 30257687
    2. Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors PMID: 27916441
    3. FGF13 was downregulated in human placentae with early-onset preeclampsia. FGF13 played an important role in maintaining placental trophoblast permeability via the modulation of E-cadherin. PMID: 29405966
    4. We propose that, in cells in which activated oncogenes drive excessive protein synthesis, FGF13 may favor survival by maintaining translation rates at a level compatible with the protein quality-control capacity of the cell. Thus, FGF13 may serve as an enabler, allowing cancer cells to evade proteostasis stress triggered by oncogene activation. PMID: 27994142
    5. Study screened the coding and splice site regions of the FGF13 gene in a sample of 45 unrelated probands where genetic epilepsy with febrile seizures plus segregated in an X-linked pattern; subsequently identified a de novo FGF13 missense variant in an additional patient with febrile seizures and facial edema. Results suggest that FGF13 is not a common cause of genetic epilepsy with febrile seizures plus. PMID: 27810516
    6. identified two novel native phosphorylation sites in the C terminus of NaV1.5 that impair FGF13-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts. PMID: 28882890
    7. These data showed the diversity of the roles of the FGF13 N-termini in NaV1.5 channel modulation and suggested the importance of isoform-specific regulation PMID: 27246624
    8. the FGF13/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals PMID: 28162808
    9. for PCa patients after RP, FGF13 serves as a potential novel prognostic marker that improves prediction of BCR-free survival, in particular if combined with other clinical parameters. PMID: 26891277
    10. The findings of this study reveal a novel cause of this syndrome and underscore the powerful role of FGF13 in control of neuronal excitability. PMID: 26063919
    11. X-chromosome deletions may be a cause of WS with larger deletions being lethal to males and that FGF13 mutations may be a cause of Wildervanck Syndrome (WS). PMID: 23373430
    12. Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells PMID: 24113164
    13. FGF13 has a role in hair follicle growth and in the hair cycle as shown in a family with X-linked congenital generalized hypertrichosis PMID: 23603273
    14. interactions with perlecans PMID: 11847221
    15. identification of a domain controlling angiogenic properties PMID: 12496262
    16. FHF2B is an interacting partner of Na(v)1.6. The preferential expression of FHF2B in sensory neurons may provide a basis for physiological differences in sodium currents that have been reported at the nodes of Ranvier in sensory versus motor axons. PMID: 15282281

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  • 亞細(xì)胞定位:
    Cell projection, filopodium. Cell projection, growth cone. Cell projection, dendrite. Nucleus. Cytoplasm.; [Isoform 1]: Nucleus, nucleolus.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族:
    Heparin-binding growth factors family
  • 組織特異性:
    Ubiquitously expressed. Predominantly expressed in the nervous system.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3670

    OMIM: 300070

    KEGG: hsa:2258

    STRING: 9606.ENSP00000359635

    UniGene: Hs.6540



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