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FCMR Antibody

  • 中文名稱(chēng)：
    FCMR兔多克隆抗體
  • 貨號(hào)：
    CSB-PA007972ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA007972ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) FCMR Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FCMR
  • 別名：
    FCMR; FAIM3; TOSO; Fas apoptotic inhibitory molecule 3; IgM Fc fragment receptor; Regulator of Fas-induced apoptosis Toso
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Fas apoptotic inhibitory molecule 3 protein (18-251AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
  • 基因功能參考文獻(xiàn)：
    1. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia. PMID: 21264533
    2. Toso/FcmuR is an IgM receptor capable of activating signaling molecules and whose expression alone is not inherently antiapoptotic. PMID: 22675200
    3. Overexpression of TOSO in chronic lymphocytic leukemia is associated with disease progression. PMID: 21756805
    4. Enhanced levels of both membrane-bound and soluble forms of FcmuR in CLL patients. PMID: 21908424
    5. TOSO/FAIM3 may play a role in immune surveillance and contribute to B cell activation PMID: 21908732
    6. TOSO is overexpressed and correlated with disease progression in chronic lymphocytic leukemia. PMID: 21133733
    7. This review focuses on possible functional consequences of Plasmodium falciparum EMP1 protein interaction with the IgM receptor, including interference with immunologic signaling and clearance mechanisms and blocking of specific antibody binding. PMID: 20410497
    8. These results identify TOSO/FAIM3 as a receptor for IgM PMID: 20042454
    9. enzymatically modified-LDL-generated foam cells are protected from cell death most likely through the expression of TOSO by a FLIP(L) independent mechanism PMID: 17553462
    10. demonstrated a 5.6-fold increase of TOSO protein in circulating CLL cells and lymph nodes PMID: 18434611
    11. association with unmutated IgV(H) and the specific induction of TOSO via the BCR suggest autoreactive BCR signaling as a key mediator of apoptosis resistance in CLL. PMID: 18708628
    12. TOSO as a mediator of resistance to apoptosis in chronic lymphocytic leukemia [review] PMID: 19347734
    13. Although this receptor was initially designated as Fas apoptotic inhibitory molecule 3, or TOSO, our results indicate that FcmuR per se has no inhibitory activity in Fas-mediated apoptosis PMID: 19858324

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  • 亞細(xì)胞定位：
    [Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 3]: Secreted.
  • 組織特異性：
    Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression det
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14315

    OMIM: 606015

    KEGG: hsa:9214

    STRING: 9606.ENSP00000356058

    UniGene: Hs.58831



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