在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FAIM3 Antibody

FAIM3 Antibody

  • 中文名稱：
    FAIM3兔多克隆抗體
  • 貨號：
    CSB-PA127416
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA127416(FAIM3 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human lymphoma tissue, Primary antibody: CSB-PA127416(FAIM3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    FCMR
  • 別名：
    FCMR; FAIM3; TOSO; Fas apoptotic inhibitory molecule 3; IgM Fc fragment receptor; Regulator of Fas-induced apoptosis Toso
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human FAIM3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:20-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
  • 基因功能參考文獻：
    1. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia. PMID: 21264533
    2. Toso/FcmuR is an IgM receptor capable of activating signaling molecules and whose expression alone is not inherently antiapoptotic. PMID: 22675200
    3. Overexpression of TOSO in chronic lymphocytic leukemia is associated with disease progression. PMID: 21756805
    4. Enhanced levels of both membrane-bound and soluble forms of FcmuR in CLL patients. PMID: 21908424
    5. TOSO/FAIM3 may play a role in immune surveillance and contribute to B cell activation PMID: 21908732
    6. TOSO is overexpressed and correlated with disease progression in chronic lymphocytic leukemia. PMID: 21133733
    7. This review focuses on possible functional consequences of Plasmodium falciparum EMP1 protein interaction with the IgM receptor, including interference with immunologic signaling and clearance mechanisms and blocking of specific antibody binding. PMID: 20410497
    8. These results identify TOSO/FAIM3 as a receptor for IgM PMID: 20042454
    9. enzymatically modified-LDL-generated foam cells are protected from cell death most likely through the expression of TOSO by a FLIP(L) independent mechanism PMID: 17553462
    10. demonstrated a 5.6-fold increase of TOSO protein in circulating CLL cells and lymph nodes PMID: 18434611
    11. association with unmutated IgV(H) and the specific induction of TOSO via the BCR suggest autoreactive BCR signaling as a key mediator of apoptosis resistance in CLL. PMID: 18708628
    12. TOSO as a mediator of resistance to apoptosis in chronic lymphocytic leukemia [review] PMID: 19347734
    13. Although this receptor was initially designated as Fas apoptotic inhibitory molecule 3, or TOSO, our results indicate that FcmuR per se has no inhibitory activity in Fas-mediated apoptosis PMID: 19858324

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 3]: Secreted.
  • 組織特異性：
    Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression det
  • 數據庫鏈接：

    HGNC: 14315

    OMIM: 606015

    KEGG: hsa:9214

    STRING: 9606.ENSP00000356058

    UniGene: Hs.58831



主站蜘蛛池模板： 亚洲日韩国产一区二区三区| 少妇精品久久久一区二区三区| 久久久久国色av免费观看| 欧美老熟妇乱子| 国产精品美女久久久久久久久| 少女韩国电视剧在线观看完整| 狠狠色婷婷久久综合频道日韩| 亚洲综合av色婷婷| 国产超碰人人爽人人做av| 色婷婷av一区二区三区浪潮| 隔壁人妻偷人bd中字| 天堂网www在线资源中文| 亚洲免费网站观看视频| 牲交a欧美牲交aⅴ免费一| 一本久道综合色婷婷五月| 国产日产亚洲系列最新| 国内精品视频自在一区| 在线|国产精品女主播阳台| 成人精品一区二区三区在线观看| 天堂а√在线中文在线最新版| 亚洲国产一区二区三区| 粉嫩粉嫩的18在线观看| 亚洲手机在线人成网站| 国产激情高中生呻吟视频| 亚洲a∨国产av综合av下载| 欧美午夜精品久久久久久浪潮| 国产成人mv视频在线观看| 欧美人与动性xxxxx交性| 日本va欧美va精品发布| 欧美zozo另类特级| 亚洲精品无码久久毛片波多野吉衣 | 免费人成视频x8x8入口| 亚洲性无码一区二区三区| 国产美女露脸口爆吞精| 亚洲日本在线电影| 风韵丰满熟妇啪啪区老熟熟女| 少妇被躁爽到高潮| 日日摸日日碰夜夜爽无码| 亚洲熟妇无码另类久久久 | 国产成人精品.视频| 国产三级视频在线播放线观看|