在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. FAIM3 Antibody

FAIM3 Antibody

  • 中文名稱：
    FAIM3兔多克隆抗體
  • 貨號：
    CSB-PA890678
  • 規格：
    ￥1100
  • 圖片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Jurkat cells, human lymphoma tissue, Primary antibody: CSB-PA890678(FAIM3 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    FCMR
  • 別名：
    FCMR; FAIM3; TOSO; Fas apoptotic inhibitory molecule 3; IgM Fc fragment receptor; Regulator of Fas-induced apoptosis Toso
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Fusion protein of Human FAIM3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
  • 基因功能參考文獻：
    1. Overexpression of TOSO gene is associated with chronic lymphocytic leukemia. PMID: 21264533
    2. Toso/FcmuR is an IgM receptor capable of activating signaling molecules and whose expression alone is not inherently antiapoptotic. PMID: 22675200
    3. Overexpression of TOSO in chronic lymphocytic leukemia is associated with disease progression. PMID: 21756805
    4. Enhanced levels of both membrane-bound and soluble forms of FcmuR in CLL patients. PMID: 21908424
    5. TOSO/FAIM3 may play a role in immune surveillance and contribute to B cell activation PMID: 21908732
    6. TOSO is overexpressed and correlated with disease progression in chronic lymphocytic leukemia. PMID: 21133733
    7. This review focuses on possible functional consequences of Plasmodium falciparum EMP1 protein interaction with the IgM receptor, including interference with immunologic signaling and clearance mechanisms and blocking of specific antibody binding. PMID: 20410497
    8. These results identify TOSO/FAIM3 as a receptor for IgM PMID: 20042454
    9. enzymatically modified-LDL-generated foam cells are protected from cell death most likely through the expression of TOSO by a FLIP(L) independent mechanism PMID: 17553462
    10. demonstrated a 5.6-fold increase of TOSO protein in circulating CLL cells and lymph nodes PMID: 18434611
    11. association with unmutated IgV(H) and the specific induction of TOSO via the BCR suggest autoreactive BCR signaling as a key mediator of apoptosis resistance in CLL. PMID: 18708628
    12. TOSO as a mediator of resistance to apoptosis in chronic lymphocytic leukemia [review] PMID: 19347734
    13. Although this receptor was initially designated as Fas apoptotic inhibitory molecule 3, or TOSO, our results indicate that FcmuR per se has no inhibitory activity in Fas-mediated apoptosis PMID: 19858324

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Membrane; Single-pass membrane protein.; [Isoform 3]: Secreted.
  • 組織特異性：
    Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat, CEM-T4, MOLT-4, HB11;19 and Reh. No expression det
  • 數據庫鏈接：

    HGNC: 14315

    OMIM: 606015

    KEGG: hsa:9214

    STRING: 9606.ENSP00000356058

    UniGene: Hs.58831



主站蜘蛛池模板： 97一区二区国产好的精华液| 国产亚洲曝欧美不卡精品 | 日本在线a一区视频高清视频| 免费国产高清在线精品一区| 亚洲一区二区三区小说| 国语国产精精品国产国语清晰对话 | 国产饥渴孕妇在线播放| 性xxxx欧美老妇506070| 韩国美女视频黄是免费| 中文字幕日韩精品亚洲一区 | 性欧美牲交在线视频| 天天爽天天爽天天爽| 又色又污又爽又黄的网站| 久久久精品2019免费观看| 久久www免费人成_看片老司机| 久久久久成人精品| 国产精品-区区久久久狼| 成人爽a毛片免费看| 日韩免费无码专区精品观看| 日本高清aⅴ毛片免费| 国模裸体无码xxxx视频| 国产一区二区三区在线电影| 久久不见久久见www电影免费| 国内老熟妇对白xxxxhd| 韩国三级中文字幕hd久久精品 | а√在线中文网新版地址在线| 极品少妇hdxx麻豆hdxx| 一本久道久久综合久久爱| 丰满少妇高潮惨叫久久久| 欧美成人精品三级网站| 在线 无码 中文字幕 强 乱| 五月婷婷久久草| 18禁美女裸体无遮挡网站| 国产精品福利自产拍在线观看| 久久国产精品免费一区| 中文字幕人乱码中文| 18禁美女裸体网站无遮挡| 国产欧美日韩视频怡春院| 777米奇色狠狠俺去啦| 亚洲性久久久影院| 欧美激欧美啪啪片免费看|