在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FBXL17 Antibody

  • 中文名稱:
    FBXL17兔多克隆抗體
  • 貨號:
    CSB-PA866216LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA866216LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FBXL17 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FBXL17
  • 別名:
    DKFZP434C1715 antibody; F box and leucine rich repeat protein 17 antibody; F box only protein 13 antibody; F box/LRR repeat protein 17 antibody; F-box and leucine-rich repeat protein 17 antibody; F-box only protein 13 antibody; F-box/LRR-repeat protein 17 antibody; FBL17 antibody; FBX13 antibody; Fbxl17 antibody; FBXO13 antibody; FXL17_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human F-box/LRR-repeat protein 17 protein (1-303AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,FBXL17 Antibody (CSB-PA866216LA01HU),的標記方式是Non-conjugated。對于FBXL17 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA866216LB01HU FBXL17 Antibody, HRP conjugated ELISA
    FITC CSB-PA866216LC01HU FBXL17 Antibody, FITC conjugated
    Biotin CSB-PA866216LD01HU FBXL17 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells. The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1. The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction. The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1.
  • 基因功能參考文獻:
    1. In summary, these findings reveal Fbxl17 as a novel regulator of the Hedgehog signaling pathway and highlight the perturbation of the Fbxl17-Sufu axis in the pathogenesis of medulloblastoma. PMID: 27234298
    2. Identify a role for SCF(FBXL17) in controlling the threshold for NRF2-dependent gene activation via BACH1 repressor turnover. PMID: 24035498
    3. F-box protein 17 (FBXL17) can serve as a therapeutic target and surrogate marker for breast cancer therapy. PMID: 18820369
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 數據庫鏈接:

    HGNC: 13615

    OMIM: 609083

    KEGG: hsa:64839

    STRING: 9606.ENSP00000437464

    UniGene: Hs.657225



主站蜘蛛池模板: 性一交一乱一伦一| av香港经典三级级 在线| 亚洲国产精品久久人人爱| 免费无码成人av在线播| 高清国产亚洲欧洲av综合一区 | 日产精品卡二卡三卡四卡乱码视频| 麻豆日产精品卡2卡3卡4卡5卡| 波多野结衣免费一区视频| 国产丝袜美女一区二区三区| 亚洲爆乳www无码专区| 四虎亚洲精品高清在线观看| 国产午夜福利视频在线观看| 无码中文字幕色专区| 色九月亚洲综合网| 97夜夜澡人人双人人人喊| 制服丝袜中文字幕在线| 欧美性生交大片免费看| 丰满少妇大叫太大太粗| 男女边吃奶边做边爱视频| 中国丰满熟妇xxxx性| 97无码免费人妻超级碰碰夜夜| 欧洲精品无码一区二区三区在线播放| 中文无码一区二区视频在线播放量| 亚洲视频高清不卡在线观看| 中文字幕精品一区二区2021年| 欧美亚洲色综久久精品国产| 女人被狂爆到高潮免费视频| 久久99er精品国产首页| 无码熟妇αⅴ人妻又粗又大| 亚洲情xo亚洲色xo无码| 欧美婷婷六月丁香综合| 亚洲另类激情综合偷自拍图| 免费无码不卡视频在线观看| 五月激激激综合网亚洲| 亚洲欧美黑人深喉猛交群| 邻居少妇张开双腿让我爽一夜 | 无码精品国产一区二区免费| 中文字幕在线影视| 极品少妇xxxx| 亚洲vav在线男人的天堂| 18级成人毛片免费观看|