在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FBXL17 Antibody, HRP conjugated

  • 中文名稱:
    FBXL17兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA866216LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FBXL17 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FBXL17
  • 別名:
    DKFZP434C1715 antibody; F box and leucine rich repeat protein 17 antibody; F box only protein 13 antibody; F box/LRR repeat protein 17 antibody; F-box and leucine-rich repeat protein 17 antibody; F-box only protein 13 antibody; F-box/LRR-repeat protein 17 antibody; FBL17 antibody; FBX13 antibody; Fbxl17 antibody; FBXO13 antibody; FXL17_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human F-box/LRR-repeat protein 17 protein (1-303AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells. The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1. The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction. The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1.
  • 基因功能參考文獻:
    1. In summary, these findings reveal Fbxl17 as a novel regulator of the Hedgehog signaling pathway and highlight the perturbation of the Fbxl17-Sufu axis in the pathogenesis of medulloblastoma. PMID: 27234298
    2. Identify a role for SCF(FBXL17) in controlling the threshold for NRF2-dependent gene activation via BACH1 repressor turnover. PMID: 24035498
    3. F-box protein 17 (FBXL17) can serve as a therapeutic target and surrogate marker for breast cancer therapy. PMID: 18820369
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 數據庫鏈接:

    HGNC: 13615

    OMIM: 609083

    KEGG: hsa:64839

    STRING: 9606.ENSP00000437464

    UniGene: Hs.657225



主站蜘蛛池模板: 色九月亚洲综合网| 国产艳妇av在线观看果冻传媒| 国产 麻豆 日韩 欧美 久久| 久久精品成人免费国产| 欧美孕妇xxxx做受欧美88| а√天堂8资源在线官网| 粗大猛烈进出高潮视频免费看| 无码人妻丰满熟妇啪啪7774| 色播在线精品一区二区三区四区 | 激情综合亚洲色婷婷五月| 国产欧美日韩亚洲18禁在线| 国产精品亚洲综合一区二区三区| 国产综合久久久久| 国产99久久亚洲综合精品西瓜tv| av无码午夜福利一区二区三区| 无码人妻丰满熟妇奶水区码 | 男女免费观看做爰视频在线观看 | 国产艳妇av在线出轨| 男女午夜猛烈啪啦啦视频| 亚洲精品久久久久久中文| 中文字幕在线免费看线人| 日本三级香港三级人妇三| 国内野外强奷在线视频| 日本猛少妇色xxxxx猛叫| 日本高清视频www夜色资源| 午夜成人无码片在线观看影院| 免费午夜福利不卡片在线播放| 久久久久成人精品免费播放动漫| 在线观看免费网页欧美成| 国语自产拍在线观看对白| 亚洲区小说区图片区qvod| 蜜臀av午夜一区二区三区| 日韩欧国产精品一区综合无码| 成人奭片免费观看| 粗大猛烈进出高潮视频免费看| 精品国产经典三级在线看| 亚洲午夜成人精品无码| 秋霞特色aa大片| 欧美日韩国产一区二区三区不卡| 手机看片精品国产福利| 真人二十三式性视频(动) |