在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FBXL17 Antibody, HRP conjugated

  • 中文名稱:
    FBXL17兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA866216LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) FBXL17 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FBXL17
  • 別名:
    DKFZP434C1715 antibody; F box and leucine rich repeat protein 17 antibody; F box only protein 13 antibody; F box/LRR repeat protein 17 antibody; F-box and leucine-rich repeat protein 17 antibody; F-box only protein 13 antibody; F-box/LRR-repeat protein 17 antibody; FBL17 antibody; FBX13 antibody; Fbxl17 antibody; FBXO13 antibody; FXL17_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human F-box/LRR-repeat protein 17 protein (1-303AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells. The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1. The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction. The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1.
  • 基因功能參考文獻:
    1. In summary, these findings reveal Fbxl17 as a novel regulator of the Hedgehog signaling pathway and highlight the perturbation of the Fbxl17-Sufu axis in the pathogenesis of medulloblastoma. PMID: 27234298
    2. Identify a role for SCF(FBXL17) in controlling the threshold for NRF2-dependent gene activation via BACH1 repressor turnover. PMID: 24035498
    3. F-box protein 17 (FBXL17) can serve as a therapeutic target and surrogate marker for breast cancer therapy. PMID: 18820369
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 數據庫鏈接:

    HGNC: 13615

    OMIM: 609083

    KEGG: hsa:64839

    STRING: 9606.ENSP00000437464

    UniGene: Hs.657225



主站蜘蛛池模板: 日本熟妇乱人伦xxxx| 少妇下面好紧好多水真爽播放| 免费人成视频在线| 亚洲精品自偷自拍无码| 国产亚洲另类无码专区| 人与动人物xxxx毛片| 极品少妇被啪到呻吟喷水| 国产人成无码视频在线| 日韩精品一卡2卡3卡4卡新区 | 三级男人添奶爽爽爽视频| 国产精品成人99一区无码| 国产人妻aⅴ色偷| 精品久久久久久中文墓无码| 日本xxx在线观看免费播放| 国产露脸无套对白在线播放| 亚洲国产精彩中文乱码av| 国产人成高清在线视频99最全资源| 中国真实偷乱视频| 久久人妻内射无码一区三区| 久久精品亚洲精品国产色婷| 九九久久精品国产免费看小说| 亚洲一区二区三区四区五区六区 | 综合图片亚洲综合网站| 日韩午夜理论免费tv影院| 蜜桃av噜噜一区二区三区| 国产一区二区| 亚洲欧美日韩国产综合点击进入| 国精产品蘑菇一区一区有限| 成人动漫综合网| av大片在线无码永久免费| 无码人妻一区二区中文| 色综合久久久无码中文字幕波多| 性久久久久久| 欧洲无码精品a码无人区| 老子影院无码午夜伦不卡| 超清av在线播放不卡无码| 色伊人亚洲综合网站| 无码熟熟妇丰满人妻porn| 亚洲人成无码网站久久99热国产| 暖暖 免费 高清 日本 在线| 中本亚洲欧美国产日韩|