在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FBXL17 Antibody, Biotin conjugated

  • 中文名稱:
    FBXL17兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA866216LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) FBXL17 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FBXL17
  • 別名:
    DKFZP434C1715 antibody; F box and leucine rich repeat protein 17 antibody; F box only protein 13 antibody; F box/LRR repeat protein 17 antibody; F-box and leucine-rich repeat protein 17 antibody; F-box only protein 13 antibody; F-box/LRR-repeat protein 17 antibody; FBL17 antibody; FBX13 antibody; Fbxl17 antibody; FBXO13 antibody; FXL17_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human F-box/LRR-repeat protein 17 protein (1-303AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells. The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1. The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction. The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1.
  • 基因功能參考文獻:
    1. In summary, these findings reveal Fbxl17 as a novel regulator of the Hedgehog signaling pathway and highlight the perturbation of the Fbxl17-Sufu axis in the pathogenesis of medulloblastoma. PMID: 27234298
    2. Identify a role for SCF(FBXL17) in controlling the threshold for NRF2-dependent gene activation via BACH1 repressor turnover. PMID: 24035498
    3. F-box protein 17 (FBXL17) can serve as a therapeutic target and surrogate marker for breast cancer therapy. PMID: 18820369
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 13615

    OMIM: 609083

    KEGG: hsa:64839

    STRING: 9606.ENSP00000437464

    UniGene: Hs.657225



主站蜘蛛池模板: 四虎影视在线影院在线观看免费视频 | 少妇人妻中文字幕污| 国产成人亚洲精品无码最新| 久久这里只有是精品23| 日韩人妻无码免费视频一区二区三区| 无码国产69精品久久久孕妇| 免费观看羞羞视频网站| 日本丰满熟妇videossex一| 99热这里只有精品最新地址获取| 久久亚洲精品中文字幕一区| 国产美女裸身网站免费观看视频 | 亚洲国产精品嫩草影院| 国产一区二区| 久久99久久99精品中文字幕| 国产av大陆精品一区二区三区 | 国产精品自在自线视频| 久久婷婷色综合老司机| 97久久精品人人槡人妻人| 上司的丰满人妻中文字幕| 国产精品乱码一区二区三区| 色噜噜狠狼综合在线| 女人夜夜春高潮爽a∨片传媒| 成人乱码一区二区三区四区| 国产亚洲精品久久yy50| 波多野结衣办公室双飞| 欧美国产综合欧美视频| 成人无码男男gv在线观看网站| 国产v片在线播放免费无遮挡| 亚洲高清毛片一区二区| 精品国产一区二区三区四区阿崩| 亚洲欧美日韩中文无线码| 久久亚洲国产精品亚洲老地址| 少妇极品熟妇人妻200片| 无码少妇一区二区三区| 无码国产精品一区二区免费虚拟vr| 美女视频黄的全免费视频网站 | 一本av高清一区二区三区| 亚洲性无码av在线dvd| 日韩人妻一区二区三区免费 | 国产午夜亚洲精品午夜鲁丝片| 最爽无遮挡行房视频|