在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

FBXL17 Antibody, Biotin conjugated

  • 中文名稱:
    FBXL17兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA866216LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) FBXL17 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    FBXL17
  • 別名:
    DKFZP434C1715 antibody; F box and leucine rich repeat protein 17 antibody; F box only protein 13 antibody; F box/LRR repeat protein 17 antibody; F-box and leucine-rich repeat protein 17 antibody; F-box only protein 13 antibody; F-box/LRR-repeat protein 17 antibody; FBL17 antibody; FBX13 antibody; Fbxl17 antibody; FBXO13 antibody; FXL17_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human F-box/LRR-repeat protein 17 protein (1-303AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome. The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells. The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1. The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release of GLI1 from SUFU for proper Hh signal transduction. The SCF(FBXL17) complex mediates ubiquitination and degradation of PRMT1.
  • 基因功能參考文獻:
    1. In summary, these findings reveal Fbxl17 as a novel regulator of the Hedgehog signaling pathway and highlight the perturbation of the Fbxl17-Sufu axis in the pathogenesis of medulloblastoma. PMID: 27234298
    2. Identify a role for SCF(FBXL17) in controlling the threshold for NRF2-dependent gene activation via BACH1 repressor turnover. PMID: 24035498
    3. F-box protein 17 (FBXL17) can serve as a therapeutic target and surrogate marker for breast cancer therapy. PMID: 18820369
  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 13615

    OMIM: 609083

    KEGG: hsa:64839

    STRING: 9606.ENSP00000437464

    UniGene: Hs.657225



主站蜘蛛池模板: 男女啪啪高潮无遮挡免费| 边吃奶边添下面好爽| 天天爱天天做天天爽夜夜揉| 2018天天躁夜夜躁狠狠躁| 中文字幕精品亚洲无线码vr| 久久97久久97精品免视看| 免费人成在线观看视频高潮| 野狼av午夜福利在线| 欧美亚洲日韩国产网站| 午夜免费啪视频在线观看区| 无码一区二区三区久久精品| 亚洲精品国产suv一区| 久久国产36精品色熟妇| 九九久久精品免费观看| 亚洲精品午夜无码电影网| 国产色无码精品视频免费| 桃花色综合影院| 国产成人精品高清在线观看99| 人人做人人爽国产视| 亚洲国产码专区| 国产午夜片无码区在线播放| √最新版天堂资源在线| 日本在线a一区视频| 久爱无码免费视频在线| 久久国语露脸国产精品电影| 日本人妻人人人澡人人爽| 啪啪激情婷婷久久婷婷色五月| 亚洲 欧洲 日韩 综合av| 亚洲天堂男人影院| 在线观看一区二区三区国产免费| 国产免费一区二区三区不卡| 暴力调教一区二区三区| 亚洲午夜福利av一区二区无码| 精品亚洲一区二区三区在线播放| a v 在线视频 亚洲免费| 国内精品伊人久久久久网站| 国产精品无码人妻一区二区在线| 狂野av人人澡人人添| 亚洲性色成人av| 欧美成人a在线网站| 日本大片免a费观看视频三区|