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ERP44 Antibody

  • 中文名稱:
    ERP44兔多克隆抗體
  • 貨號:
    CSB-PA580639
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA580639(ERP44 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-7: Raji cells, A549 cells, Hela cells, HepG2 cells, 231 cells, K562 cells, A431 cells,Primary antibody: CSB-PA580639(ERP44 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Endoplasmic reticulum resident protein 44 antibody; Endoplasmic reticulum resident protein 44 kDa antibody; Endoplasmic reticulum resident protein ERp44 antibody; ER protein 44 antibody; ERp44 antibody; ERP44_HUMAN antibody; KIAA0573 antibody; PDIA10 antibody; Protein disulfide isomerase family A; member 10 antibody; Thioredoxin domain containing 4 (endoplasmic reticulum) antibody; Thioredoxin domain containing protein 4 antibody; Thioredoxin domain-containing protein 4 antibody; UNQ532/PRO1075 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human ERP44
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum.
  • 基因功能參考文獻:
    1. Endogenous ERp44 is O-glycosylated and secreted by human primary endometrial cells, suggesting possible pathophysiological roles of these processes. PMID: 25097228
    2. findings indicated that overexpression of miR-101 could downregulate ERp44 PMID: 24804790
    3. the decrease in 5-HT uptake rates of GDM trophoblast is the consequence of defective insulin signaling, which entraps SERT with ERp44 and impairs its glycosylation. PMID: 25512553
    4. The ERp44 assembly control cycle couples secretion fidelity and efficiency downstream of the calnexin/calreticulin and BiP-dependent quality control cycles. PMID: 23685074
    5. ERp44 together with Ero1-Lalpha plays an important role in disulfide formation of SERT, which may be a prerequisite step for the assembly of SERT molecules in oligomeric form. PMID: 22451649
    6. contains a thioredoxin domain with a CRFS motif and is induced during ER stress PMID: 11847130
    7. Ero1alpha and Ero1beta are retained in the endoplasmic reticulum by interactions with PDI and ERp44 PMID: 16677073
    8. ERGIC-53 provides a platform that receives micro(2)L(2) subunits from the BiP-dependent checkpoint, assisting polymerization. In this process, ERp44 couples thiol-dependent assembly and quality control. PMID: 17805346
    9. ERp44-mediated retention of FGE, indicating that noncovalent interactions between ERp44 and FGE are sufficient to mediate ER retention. PMID: 18178549
    10. Study shows that SUMF1 interacts with protein disulfide isomerase (PDI) and ERp44, two thioredoxin family members residing in the early secretory pathway, and with ERGIC-53, a lectin that shuttles between the ER and the Golgi. PMID: 18508857
    11. Crystal structure of ERp44 at a resolution of 2.6 A, is presented. PMID: 18552768

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  • 亞細胞定位:
    Endoplasmic reticulum lumen.
  • 數據庫鏈接:

    HGNC: 18311

    OMIM: 609170

    KEGG: hsa:23071

    STRING: 9606.ENSP00000262455

    UniGene: Hs.154023



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