在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EPHB6 Antibody

  • 中文名稱:
    EPHB6兔多克隆抗體
  • 貨號:
    CSB-PA002365
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HeLa cells using EphB6 Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    EPHB6
  • 別名:
    EPH receptor B6 antibody; Ephb6 antibody; EPHB6_HUMAN antibody; Ephrin type B receptor 6 precursor antibody; Ephrin type-B receptor 6 antibody; HEP antibody; MGC129910 antibody; MGC129911 antibody; Tyrosine protein kinase defective receptor EPH 6 antibody; Tyrosine-protein kinase-defective receptor EPH-6 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human EphB6.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
  • 基因功能參考文獻(xiàn):
    1. using an EphB6 mouse knockout model we found that the loss of EphB6 does not initiate intestinal tumorigenesis and is not involved in the early tumor progression through the adenoma-to-carcinoma transition. PMID: 28262839
    2. Data indicate that EphB6 protein was decreased in gastric carcinoma compared with normal mucosa. Analytic results based on pathological parameters suggests that EphB6 protein may inhibit metastasis of gastric carcinoma. PMID: 28453458
    3. Authors provide evidence that an intrinsically kinase-inactive member of the Eph group of receptor tyrosine kinases, EPHB6, induces marked fragmentation of the mitochondrial network in breast cancer cells of triple-negative origin, lacking expression of the estrogen, progesterone and HER2 receptors. PMID: 27788485
    4. SRC kinase is a synthetic lethality partner of EPHB6 in triple-negative breast cancer cells PMID: 27418135
    5. Study is the first to demonstrate that EphB6 overexpression together with Apc gene mutations may enhance proliferation, invasion and metastasis by colorectal epithelial cells. PMID: 27145271
    6. Melanomas from geographically different regions in New Zealand have markedly different mutation frequencies, in particular in the NRAS and EPHB6 genes, when compared to The Cancer Genome Atlas database or other populations. These data have implications for the causation and treatment of malignant melanoma in New Zealand. PMID: 27191502
    7. Low EPHB6 expression is associated with prostate cancer metastasis. PMID: 28826721
    8. Enhanced EphB6 expression was significantly associated with Thyroid Lesions. PMID: 26220827
    9. EphB6 protein may be used as a new marker for prognosis for tongue squamous cell carcinoma. PMID: 26617870
    10. EphB6 is a new biomarker for distinguishing high- and low-grade ovarian serous carcinoma, and may be a potential prognostic marker in ovarian serous carcinomas. PMID: 26468391
    11. EphB6 also interacts with the Hsp90 chaperone. PMID: 25152371
    12. We demonstrate that EphB6 reexpression forces metastatic melanoma cells to deviate from the canonical migration pattern observed in the chick embryo transplant model PMID: 24836890
    13. Results suggest that erythropoietin-producing hepatocyte (Eph) receptor B6 (EphB6) may represent a useful tissue biomarker for the prediction of survival rate in colorectal cancers (CRCs). PMID: 24912672
    14. Studies clearly demonstrate an inverse relationship between the levels of phospho-ERK and the abundance of cadherin 17, beta-catenin and phospho-GSK3beta in EPHB6-expressing MDA-MB-231 cells. PMID: 25331796
    15. The alterations in miRNAs and their target mRNAs also suggest indirect involvement of EphB6 in PI3K/Akt/mTOR pathways. PMID: 21811619
    16. results indicate that tumor invasiveness-suppressing activity of EPHB6 is mediated by its ability to sequester other kinase-sufficient and oncogenic EPH receptors PMID: 21737611
    17. Nonsynonymous variants of EPHB6 is associated with familial colorectal cancer. PMID: 21351276
    18. expression of more than 70 proteins was altered in EphB6-transfected MDA-MB-231 cells; proteins are involved in glycolysis, cell cycle regulation, tumor suppression, cell proliferation, mitochondrial metabolism, mRNA splicing, DNA replication and repair PMID: 20952760
    19. The loss of EPHB6 expression in more aggressive breast carcinoma cell lines is regulated in a methylation-dependent manner. The EPHB6 methylation-specific PCR has clinical implications for the prognosis and/or diagnosis of breast and other cancer types PMID: 20181626
    20. Findings suggest a new role for EphB6 in suppressing cancer invasiveness and cell attachment through c-Cbl-dependent signaling. PMID: 20086179
    21. interaction between EphB6 and its ligands facilitates T cell responses to antigen PMID: 12393850
    22. EphB6 may play an important role in regulating thymocyte differentiation and modulating responses of mature T cells. PMID: 12517763
    23. lower EphB6 expression has a role in melanoma progression to metastatic disease PMID: 14612926
    24. EphB6 can both positively and negatively regulate cell adhesion and migration PMID: 15955811
    25. The potential significance of EphB6 to serve as a diagnostic and prognostic indicator is discussed. PMID: 16364251
    26. the two peptides derived from EphB6v might be appropriate targets for peptide-based specific immunotherapy for HLA-A2(+) patients with various cancers PMID: 18754880
    27. EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells. PMID: 19234485
    28. The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma. PMID: 19513565
    29. Cross-linking of EphB6 alters profiles of lymphokine secretion, inhibits proliferation, induces Fas-mediated apoptosis of Jurkat leukemic T cells, and transduces signals into the cells via proteins it associates with. PMID: 11466354

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 組織特異性:
    Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in bre
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3396

    OMIM: 602757

    KEGG: hsa:2051

    STRING: 9606.ENSP00000376684

    UniGene: Hs.380089



主站蜘蛛池模板: 欧美人与动牲交aⅴ| 国产精品线路一线路二| 国产亚洲精aa在线观看see | 黑人尾随强伦姧人妻爽翻天| av第一福利网站| 国产重口老太和小伙| 少妇爆乳无码专区| 亚洲色成人www永久网站| 国产熟妇疯狂4p交在线播放| 亚洲成av大片大片在线播放| 国产无遮挡免费真人视频在线观看 | 亚洲第一成年免费网站| 精品日本免费一区二区三区| 99久re热视频这里只有精品6| 色88久久久久高潮综合影院| 亚洲中文字幕在线观看| 日本三级吃奶头添泬| 人人玩人人添人人澡| 国产午夜精品一二区理论影院| 中国女人内谢69xxxx免费视频| 无码少妇精品一区二区免费| 98色婷婷在线| 久久99亚洲精品久久69| 国产精品涩涩涩视频网站| 国产成人无码av| 碰超免费人妻中文字幕| 尹人香蕉99久久综合网站 | 蜜臀av性久久久久蜜臀aⅴ麻豆 | 日本亚洲欧美在线视观看| 亚洲精品久久久久国产剧8| 麻豆视传媒在线观看| 精品影片在线观看的网站| 色欲色香天天天综合无码| 国产999久久高清免费观看| 熟妇人妻av中文字幕老熟妇| 老司机亚洲精品影院无码| 国产卡二卡三卡四卡免费网址| 日韩在线成年视频人网站观看| 用舌头去添高潮无码视频| 精品国产日韩亚洲一区| 亚洲熟女av综合网五月|