在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Ephrin type-B receptor 6 (EPHB6), partial

Recombinant Human Ephrin type-B receptor 6 (EPHB6), partial

  • 中文名稱：
    人EPHB6重組蛋白
  • 貨號：
    CSB-YP007733HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人EPHB6重組蛋白
  • 貨號：
    CSB-EP007733HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人EPHB6重組蛋白
  • 貨號：
    CSB-EP007733HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人EPHB6重組蛋白
  • 貨號：
    CSB-BP007733HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人EPHB6重組蛋白
  • 貨號：
    CSB-MP007733HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    EPHB6
  • Uniprot No.：
  • 別名：
    EPH receptor B6; Ephb6; EPHB6_HUMAN; Ephrin type B receptor 6 precursor; Ephrin type-B receptor 6; HEP; MGC129910; MGC129911; Tyrosine protein kinase defective receptor EPH 6; Tyrosine-protein kinase-defective receptor EPH-6
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
  • 基因功能參考文獻：
    1. using an EphB6 mouse knockout model we found that the loss of EphB6 does not initiate intestinal tumorigenesis and is not involved in the early tumor progression through the adenoma-to-carcinoma transition. PMID: 28262839
    2. Data indicate that EphB6 protein was decreased in gastric carcinoma compared with normal mucosa. Analytic results based on pathological parameters suggests that EphB6 protein may inhibit metastasis of gastric carcinoma. PMID: 28453458
    3. Authors provide evidence that an intrinsically kinase-inactive member of the Eph group of receptor tyrosine kinases, EPHB6, induces marked fragmentation of the mitochondrial network in breast cancer cells of triple-negative origin, lacking expression of the estrogen, progesterone and HER2 receptors. PMID: 27788485
    4. SRC kinase is a synthetic lethality partner of EPHB6 in triple-negative breast cancer cells PMID: 27418135
    5. Study is the first to demonstrate that EphB6 overexpression together with Apc gene mutations may enhance proliferation, invasion and metastasis by colorectal epithelial cells. PMID: 27145271
    6. Melanomas from geographically different regions in New Zealand have markedly different mutation frequencies, in particular in the NRAS and EPHB6 genes, when compared to The Cancer Genome Atlas database or other populations. These data have implications for the causation and treatment of malignant melanoma in New Zealand. PMID: 27191502
    7. Low EPHB6 expression is associated with prostate cancer metastasis. PMID: 28826721
    8. Enhanced EphB6 expression was significantly associated with Thyroid Lesions. PMID: 26220827
    9. EphB6 protein may be used as a new marker for prognosis for tongue squamous cell carcinoma. PMID: 26617870
    10. EphB6 is a new biomarker for distinguishing high- and low-grade ovarian serous carcinoma, and may be a potential prognostic marker in ovarian serous carcinomas. PMID: 26468391
    11. EphB6 also interacts with the Hsp90 chaperone. PMID: 25152371
    12. We demonstrate that EphB6 reexpression forces metastatic melanoma cells to deviate from the canonical migration pattern observed in the chick embryo transplant model PMID: 24836890
    13. Results suggest that erythropoietin-producing hepatocyte (Eph) receptor B6 (EphB6) may represent a useful tissue biomarker for the prediction of survival rate in colorectal cancers (CRCs). PMID: 24912672
    14. Studies clearly demonstrate an inverse relationship between the levels of phospho-ERK and the abundance of cadherin 17, beta-catenin and phospho-GSK3beta in EPHB6-expressing MDA-MB-231 cells. PMID: 25331796
    15. The alterations in miRNAs and their target mRNAs also suggest indirect involvement of EphB6 in PI3K/Akt/mTOR pathways. PMID: 21811619
    16. results indicate that tumor invasiveness-suppressing activity of EPHB6 is mediated by its ability to sequester other kinase-sufficient and oncogenic EPH receptors PMID: 21737611
    17. Nonsynonymous variants of EPHB6 is associated with familial colorectal cancer. PMID: 21351276
    18. expression of more than 70 proteins was altered in EphB6-transfected MDA-MB-231 cells; proteins are involved in glycolysis, cell cycle regulation, tumor suppression, cell proliferation, mitochondrial metabolism, mRNA splicing, DNA replication and repair PMID: 20952760
    19. The loss of EPHB6 expression in more aggressive breast carcinoma cell lines is regulated in a methylation-dependent manner. The EPHB6 methylation-specific PCR has clinical implications for the prognosis and/or diagnosis of breast and other cancer types PMID: 20181626
    20. Findings suggest a new role for EphB6 in suppressing cancer invasiveness and cell attachment through c-Cbl-dependent signaling. PMID: 20086179
    21. interaction between EphB6 and its ligands facilitates T cell responses to antigen PMID: 12393850
    22. EphB6 may play an important role in regulating thymocyte differentiation and modulating responses of mature T cells. PMID: 12517763
    23. lower EphB6 expression has a role in melanoma progression to metastatic disease PMID: 14612926
    24. EphB6 can both positively and negatively regulate cell adhesion and migration PMID: 15955811
    25. The potential significance of EphB6 to serve as a diagnostic and prognostic indicator is discussed. PMID: 16364251
    26. the two peptides derived from EphB6v might be appropriate targets for peptide-based specific immunotherapy for HLA-A2(+) patients with various cancers PMID: 18754880
    27. EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells. PMID: 19234485
    28. The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma. PMID: 19513565
    29. Cross-linking of EphB6 alters profiles of lymphokine secretion, inhibits proliferation, induces Fas-mediated apoptosis of Jurkat leukemic T cells, and transduces signals into the cells via proteins it associates with. PMID: 11466354

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 組織特異性：
    Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in bre
  • 數據庫鏈接：

    HGNC: 3396

    OMIM: 602757

    KEGG: hsa:2051

    STRING: 9606.ENSP00000376684

    UniGene: Hs.380089



主站蜘蛛池模板： 青青久久成人免费影院| 成人免费看黄网站yyy456 | 午夜男女无遮挡拍拍视频| 欧美亚洲另类丝袜综合网| 国产精品久久久久久久久绿色| 亚洲老妇色熟女老太| 青青草av一区二区三区| 国产免费无遮挡吸乳视频在线观看| 无码加勒比一区二区三区四区| 99久久99久久精品国产片果冻| 无码精品国产一区二区三区免费| 国产无遮挡色视频免费观看性色| 欧美另类又黄又爽的a片| 小嫩妇好紧好爽18禁视频| 99亚洲男女激情在线观看| 国产成人精品成人a在线观看| 男女裸交无遮挡啪啪激情试看| 亚洲а∨精品天堂在线| 色依依av在线| 亚洲日韩一区二区一无码| 亚洲色播永久网址大全| 少妇高潮喷水久久久久久久久久| 九一九色国产| 一本之道av不卡精品| 国产精品卡一卡2卡3卡4| 国精品无码一区二区三区左线 | 熟女人妻水多爽中文字幕| 天堂网www中文在线 | 国产精品无码av不卡顿| 欧美又大又色又爽aaaa片| 亚洲a片国产av一区无码| 久久99精品久久久久久2021| 日本成本人片免费网站| 老妇肥熟凸凹丰满刺激| 曰韩精品无码一区二区视频| 99久久er热在这里只有精品99| 久久精品一区二区三区av| 国产av亚洲精品久久久久久| 亚洲成av人片在线观看高清 | 亚洲精品中文字幕| 又紧又大又爽精品一区二区|