在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EPHB6 Antibody

  • 中文名稱:
    EPHB6兔多克隆抗體
  • 貨號:
    CSB-PA017084
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, 293 cells and COLO cells, using EPHB6 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using EPHB6 antibody.
    • Immunofluorescence analysis of HeLa cells, using EPHB6 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EPHB6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EPHB6
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human EPHB6.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2.
  • 基因功能參考文獻:
    1. using an EphB6 mouse knockout model we found that the loss of EphB6 does not initiate intestinal tumorigenesis and is not involved in the early tumor progression through the adenoma-to-carcinoma transition. PMID: 28262839
    2. Data indicate that EphB6 protein was decreased in gastric carcinoma compared with normal mucosa. Analytic results based on pathological parameters suggests that EphB6 protein may inhibit metastasis of gastric carcinoma. PMID: 28453458
    3. Authors provide evidence that an intrinsically kinase-inactive member of the Eph group of receptor tyrosine kinases, EPHB6, induces marked fragmentation of the mitochondrial network in breast cancer cells of triple-negative origin, lacking expression of the estrogen, progesterone and HER2 receptors. PMID: 27788485
    4. SRC kinase is a synthetic lethality partner of EPHB6 in triple-negative breast cancer cells PMID: 27418135
    5. Study is the first to demonstrate that EphB6 overexpression together with Apc gene mutations may enhance proliferation, invasion and metastasis by colorectal epithelial cells. PMID: 27145271
    6. Melanomas from geographically different regions in New Zealand have markedly different mutation frequencies, in particular in the NRAS and EPHB6 genes, when compared to The Cancer Genome Atlas database or other populations. These data have implications for the causation and treatment of malignant melanoma in New Zealand. PMID: 27191502
    7. Low EPHB6 expression is associated with prostate cancer metastasis. PMID: 28826721
    8. Enhanced EphB6 expression was significantly associated with Thyroid Lesions. PMID: 26220827
    9. EphB6 protein may be used as a new marker for prognosis for tongue squamous cell carcinoma. PMID: 26617870
    10. EphB6 is a new biomarker for distinguishing high- and low-grade ovarian serous carcinoma, and may be a potential prognostic marker in ovarian serous carcinomas. PMID: 26468391
    11. EphB6 also interacts with the Hsp90 chaperone. PMID: 25152371
    12. We demonstrate that EphB6 reexpression forces metastatic melanoma cells to deviate from the canonical migration pattern observed in the chick embryo transplant model PMID: 24836890
    13. Results suggest that erythropoietin-producing hepatocyte (Eph) receptor B6 (EphB6) may represent a useful tissue biomarker for the prediction of survival rate in colorectal cancers (CRCs). PMID: 24912672
    14. Studies clearly demonstrate an inverse relationship between the levels of phospho-ERK and the abundance of cadherin 17, beta-catenin and phospho-GSK3beta in EPHB6-expressing MDA-MB-231 cells. PMID: 25331796
    15. The alterations in miRNAs and their target mRNAs also suggest indirect involvement of EphB6 in PI3K/Akt/mTOR pathways. PMID: 21811619
    16. results indicate that tumor invasiveness-suppressing activity of EPHB6 is mediated by its ability to sequester other kinase-sufficient and oncogenic EPH receptors PMID: 21737611
    17. Nonsynonymous variants of EPHB6 is associated with familial colorectal cancer. PMID: 21351276
    18. expression of more than 70 proteins was altered in EphB6-transfected MDA-MB-231 cells; proteins are involved in glycolysis, cell cycle regulation, tumor suppression, cell proliferation, mitochondrial metabolism, mRNA splicing, DNA replication and repair PMID: 20952760
    19. The loss of EPHB6 expression in more aggressive breast carcinoma cell lines is regulated in a methylation-dependent manner. The EPHB6 methylation-specific PCR has clinical implications for the prognosis and/or diagnosis of breast and other cancer types PMID: 20181626
    20. Findings suggest a new role for EphB6 in suppressing cancer invasiveness and cell attachment through c-Cbl-dependent signaling. PMID: 20086179
    21. interaction between EphB6 and its ligands facilitates T cell responses to antigen PMID: 12393850
    22. EphB6 may play an important role in regulating thymocyte differentiation and modulating responses of mature T cells. PMID: 12517763
    23. lower EphB6 expression has a role in melanoma progression to metastatic disease PMID: 14612926
    24. EphB6 can both positively and negatively regulate cell adhesion and migration PMID: 15955811
    25. The potential significance of EphB6 to serve as a diagnostic and prognostic indicator is discussed. PMID: 16364251
    26. the two peptides derived from EphB6v might be appropriate targets for peptide-based specific immunotherapy for HLA-A2(+) patients with various cancers PMID: 18754880
    27. EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells. PMID: 19234485
    28. The kinase defective EPHB6 receptor tyrosine kinase activates MAP kinase signaling in lung adenocarcinoma. PMID: 19513565
    29. Cross-linking of EphB6 alters profiles of lymphokine secretion, inhibits proliferation, induces Fas-mediated apoptosis of Jurkat leukemic T cells, and transduces signals into the cells via proteins it associates with. PMID: 11466354

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
  • 蛋白家族:
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 組織特異性:
    Expressed in brain. Expressed in non invasive breast carcinoma cell lines (at protein level). Strong expression in brain and pancreas, and weak expression in other tissues, such as heart, placenta, lung, liver, skeletal muscle and kidney. Expressed in bre
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3396

    OMIM: 602757

    KEGG: hsa:2051

    STRING: 9606.ENSP00000376684

    UniGene: Hs.380089



主站蜘蛛池模板: 成人毛片100免费观看| 中文字幕人妻无码视频| 亚洲日韩欧洲乱码av夜夜摸| 午夜福利理论片在线观看播放| 中文字幕乱码中文乱码777| 中文字幕亚洲乱码熟女在线| 色妺妺av爽爽影院| 大胸美女污污污www网站| 人人摸人人搞人人透| 色77久久综合网| 久久久综合香蕉尹人综合网| 亚洲综合另类小说色区| 老司机性色福利精品视频| 四虎www成人影院观看| 国产卡一卡二卡三无线乱码新区 | 18禁黄无遮挡网站| 国产亚洲精品久久久久久小舞| 在线天堂资源www在线中文 | 国产精品久久久爽爽爽麻豆色哟哟 | 日本丰满护士爆乳xxxx| 天堂最新版在线www官网中文地址 最新国产麻豆aⅴ精品无码 | 午夜一区一品日本| 国产在视频线精品视频| 骚女人干起来舒服视频在线| 久久天天躁夜夜躁狠狠躁| 亚洲午夜精品久久久久久人妖| 波多野吉衣av无码| 亚洲综合小说另类图片五月天| 国产果冻豆传媒麻婆精东| 久久久亚洲精品成人| 老熟女重囗味hdxx69| 特黄做受又硬又粗又大视频小说| 欧美饥渴少妇xxxxx性| 青青草大香焦在线综合视频 | 国内揄拍国内精品对白86| 动漫成人无码精品一区二区三区 | 亚洲精品久久国产精品| 亚洲熟女乱色一区二区三区| 天天狠天天天天透在线| 国产成人无码av在线播放不卡| 欧美亚洲精品一区二区|