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  4. EME1 Antibody

EME1 Antibody

  • 中文名稱：
    EME1兔多克隆抗體
  • 貨號：
    CSB-PA856897LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA856897LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA856897LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) EME1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    EME1
  • 別名：
    6820428D13 antibody; Crossover junction endonuclease EME1 antibody; EC 3.1.22.- antibody; EME1 antibody; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe) antibody; EME1; S. pombe; homolog of; 1 antibody; EME1_HUMAN antibody; essential meiotic endonuclease 1 homolog 1 (S pombe) antibody; Essential Meiotic Endonuclease 1 Homolog 1 antibody; essential meiotic endonuclease 1 homolog 2 antibody; Essential meiotic endonuclease 1; S. pombe; homolog of; 1 antibody; FLJ31364 antibody; hMMS4 antibody; homolog of yeast EME1 endonuclease antibody; MGC106543 antibody; MMS4 antibody; MMS4 homolog antibody; MMS4L antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Crossover junction endonuclease EME1 protein (1-583AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，EME1 Antibody (CSB-PA856897LA01HU)，的標記方式是Non-conjugated。對于EME1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA856897LB01HU EME1 Antibody, HRP conjugated ELISA
    FITC CSB-PA856897LC01HU EME1 Antibody, FITC conjugated
    Biotin CSB-PA856897LD01HU EME1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
  • 基因功能參考文獻：
    1. The data suggest that subnuclear relocalization is relevant for the function of Mus81-Mms4 complex in response to DNA damage and, probably, of the endonucleases that colocalize with it. PMID: 28813668
    2. EME-1 deficiency affects cell cycle progression and promotes DNA rereplication. PMID: 16456034
    3. Low Eme1 levels were more sensitive to the drug than tumors with high levels. PMID: 19267403
  • 亞細胞定位：
    Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells.
  • 蛋白家族：
    EME1/MMS4 family
  • 數據庫鏈接：

    HGNC: 24965

    OMIM: 610885

    KEGG: hsa:146956

    STRING: 9606.ENSP00000376952

    UniGene: Hs.514330



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