在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EIF4B Antibody

  • 中文名稱:
    EIF4B兔多克隆抗體
  • 貨號:
    CSB-PA007554GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    2310046H11Rik antibody; AL024095 antibody; C85189 antibody; EIF 4B antibody; eIF-4B antibody; EIF4B antibody; Eukaryotic initiation factor 4B antibody; Eukaryotic translation initiation factor 4B antibody; IF4B_HUMAN antibody; PRO1843 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human EIF4B
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
  • 基因功能參考文獻:
    1. FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma. PMID: 29483509
    2. Synthesis of MCL1, an antiapoptotic protein known to play a role in cancer cell survival during cell division, depends on the function of MELK-elF4B signaling. PMID: 27528663
    3. Together, our data show that mAChRs modulate eIF4B phosphorylation via the ERK1/2 and PKC signaling pathways in SNU-407 colon cancer cells. PMID: 27773818
    4. Results indicate that eIF4B integrates the signals from Pim and PI3K/Akt/mTOR pathways in Abl-expressing leukemic cells. PMID: 26848623
    5. MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B. PMID: 25955794
    6. S6K1 enhances c-Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to unwind its structured 5' untranslated region. PMID: 25220053
    7. eIF4B is the RSK downstream effector responsible for elevated Lamgamma2 as well as MYC protein in neoplastic epithelial cells. PMID: 24205356
    8. The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus. PMID: 24829357
    9. eIF4B-driven expression of these key survival proteins is directly correlated with patient outcome, and eIF4B, DAXX and ERCC5 are identified as novel prognostic markers for poor survival in DLBCL PMID: 24135829
    10. Report EIF4B binding within the IRES domain V of the coxsackie virus B3 mutant strain. PMID: 24063684
    11. Overexpression of pim-2 may inhibit the apoptosis of prostate cancer cells through phosphorylation of eIF4B, thus promoting tumorigenesis. PMID: 23813671
    12. our results identify eIF4B as a critical substrate of Pim kinases in mediating the activity of Abl oncogenes PMID: 23749639
    13. ORF45/RSK axis-induced eIF4B phosphorylation is involved in translational regulation and is required for optimal KSHV lytic replication. PMID: 21994950
    14. The solution structure of the eIF4B RNA recognition motif (RRM) domain is reported; the core RRM domain provides only a relative weak interaction with RNA targets and appears to require extensions at the N- and C-terminus for high-affinity binding. PMID: 12885229
    15. eIF4B may mediate some of the effects of the ribosomal protein S6 kinases on translation PMID: 15071500
    16. data indicate that eIF4B and 4H stimulate the nuclease activity of herpes simplex virus vhs, and they provide evidence that additional mammalian factors are required for targeting to the encephalomyocarditis virus IRES PMID: 15078951
    17. Phosphorylation of eIF4B on Ser422 by p90 ribosomal protein S6 kinase (RSK) and S6K is physiologically significant, as it increases the interaction of eIF4B with the eukaryotic translation initiation factor 3. PMID: 16763566
    18. Data show that reduced levels of eIF4B, eIF4H, or polyA-binding protein, also trigger SG formation. PMID: 19369421

    顯示更多

    收起更多

  • 數(shù)據(jù)庫鏈接:

    HGNC: 3285

    OMIM: 603928

    KEGG: hsa:1975

    STRING: 9606.ENSP00000262056

    UniGene: Hs.648394



主站蜘蛛池模板: 成人永久免费网站在线观看| 亚洲欧美日韩国产自偷| 无码人妻一区二区三区av | 国内精品人妻无码久久久影院| 国产精品午夜福利不卡120| 国产在线精品欧美日韩电影 | 亚洲人av在线无码影院观看| 久久毛片免费看一区二区三区| 蜜臀avwww国产天堂| 少妇无码吹潮| 性色a∨精品高清在线观看| 人妻少妇无码精品专区| 人妻换人妻a片爽麻豆| 午夜精品久久久久久中宇| 国产高清午夜人成在线观看| 亚洲精品av一区在线观看| 色综合久久网| 国产激情视频一区二区三区| 日本看片一二三区高清| 性色欲情网站iwww九文堂| 日韩 欧美 动漫 国产 制服| 久久香蕉国产线看观看怡红院妓院| 亚洲国产成人精品无码区宅男| 亚洲一区二区三区含羞草| 欧美激情日韩精品久久久| 日本精品中文字幕在线播放| 日本xxxx少妇高清hd| 国产精品爽爽久久久久久蜜臀| 无码熟妇人妻av在线影片最多| 在线va无卡无码高清| 亚洲一区二区三区| 亚洲中文字幕无码一久久区| 国产粉嫩嫩00在线正在播放| 国产成人愉拍精品| 波多野吉衣av无码| 性夜影院午夜看片| 国产精品禁18久久久夂久| 秋霞午夜成人久久电影网| 特殊重囗味sm在线观看无码| 啪一啪射一射插一插| 久久精品国产99国产精品澳门 |