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EIF3C Antibody, HRP conjugated

  • 中文名稱:
    EIF3C兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA857867LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EIF3C Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EIF3C
  • 別名:
    Cell migration inducing protein 17 antibody; eIF 3c antibody; eIF3 p110 antibody; eIF3-p110 antibody; eIF3c antibody; EIF3C_HUMAN antibody; EIF3CL antibody; EIF3S8 antibody; EIF3S8 protein antibody; Eukaryotic translation initiation factor 3 subunit 8 (110kD) antibody; Eukaryotic translation initiation factor 3 subunit 8 110kDa antibody; Eukaryotic translation initiation factor 3 subunit 8 antibody; Eukaryotic translation initiation factor 3 subunit C antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Eukaryotic translation initiation factor 3 subunit C protein (201-500AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
  • 基因功能參考文獻:
    1. In EIF3C-positive tumors, 32 out of 42 showed significantly higher frequencies of high grade group by immunoreactivity. PMID: 28854163
    2. High eIF3c expression is positively associated with KRAS. PMID: 28231410
    3. These findings suggest that eIF3c is overexpressed in human gliomas and essential for their proliferation and survival. PMID: 25823503
    4. eukaryotic initiation factor 4G (eIF4G) protein binds to eIF3c, -d, and -e to promote mRNA recruitment to the ribosome. PMID: 24092755
    5. Collectively, eIF3c deletion effectively reduced the survival of colon cancer cells and could be used as a therapeutic tool for colon cancer therapy. PMID: 23733421
    6. These results indicate that the interaction between Hsp90 and eIF3c may play an important role in hepatitis C virus internal ribosome entry site-mediated translation. PMID: 22016036

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  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    EIF-3 subunit C family
  • 數據庫鏈接:

    HGNC: 3279

    OMIM: 603916

    KEGG: hsa:8663

    STRING: 9606.ENSP00000332604

    UniGene: Hs.567374



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