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  4. EDA2R Antibody

EDA2R Antibody

  • 中文名稱：
    EDA2R兔多克隆抗體
  • 貨號：
    CSB-PA881011ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA881011ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA881011ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) EDA2R Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    EDA2R
  • 別名：
    9430060M22Rik antibody; Ectodysplasin A2 isoform receptor antibody; Ectodysplasin A2 receptor antibody; EDA A2R antibody; EDA-A2 receptor antibody; EDA2R antibody; EDAA2R antibody; MGC124099 antibody; OTTMUSP00000019574 antibody; OTTMUSP00000019575 antibody; RP23-188N15.1 antibody; TNFRSF27 antibody; TNR27_HUMAN antibody; Tumor necrosis factor receptor superfamily member 27 antibody; Tumor necrosis factor receptor superfamily member XEDAR antibody; X linked ectodysplasin A2 receptor antibody; X linked ectodysplasin receptor antibody; X-linked ectodysplasin-A2 receptor antibody; XEDAR antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tumor necrosis factor receptor superfamily member 27 protein (1-138AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
  • 基因功能參考文獻：
    1. We found evidence for AR but not EDA2R as the candidate gene at the androgenetic alopecia risk locus on chromosome X. PMID: 27060448
    2. EDA-A2 and its receptor XEDAR are overexpressed in epithelial cells of salivary glands in Sjogren's syndrome patients, in comparison with healthy individuals. The EDA-A2/XEDAR system in these cells is involved in the induction of apoptosis via CASP3 activation. PMID: 26659383
    3. XEDAR activates the non-canonical NF-kappaB pathway. PMID: 26260321
    4. To investigate the evolutionary history of the EDA2R/AR intergenic region, we characterized the haplotype structure of 52 of its highly differentiated SNPs. Nearly all human X chromosomes carry one of two modal haplotypes for these 52 SNPs. PMID: 23959643
    5. The results suggest that EDA2R confers susceptibility to early onset female pattern hair loss PMID: 22309448
    6. association in dental crowding in the Hong Kong Chinese population PMID: 21724072
    7. A crucial role of the EDA-A2/ectodysplasin A2 (XEDAR) interaction is revealed in the p53-signaling pathway. PMID: 20501644
    8. because no frequent variant other than rs1385699 has been reported in EDA2R in the European population, it is probable that the causative variant(s) modifies the expression of one or more flanking genes, i.e. AR and EDA2R PMID: 20199557
    9. Results establish a major role of TRAF3 and -6 in X-linked ectodermal dysplasia receptor (XEDAR) signaling and in the process of ectodermal differentiation. PMID: 12270937
    10. XEDAR belongs to a novel class of death receptors that lack a discernible death domain but are capable of activating apoptosis in a caspase 8- and FADD-dependent fashion PMID: 15280356
    11. isoforms of EDA-A5 and A5',activated NF-kappaB through receptors EDAR and XEDAR PMID: 16423472
    12. The androgen receptor gene and EDA2R are significantly associated with androgenetic alopecia. PMID: 18385763
    13. androgen receptor/ectodysplasin A2 receptor haplotype may have a role in male pattern baldness PMID: 19373488
    14. XEDAR is a putative tumor suppressor that could prevent malignant transformation and tumor progression by regulating apoptosis and anoikis. PMID: 19543321

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  • 亞細胞定位：
    Membrane; Single-pass type III membrane protein.
  • 數據庫鏈接：

    HGNC: 17756

    OMIM: 300276

    KEGG: hsa:60401

    UniGene: Hs.302017



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