在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EBF3 Antibody

  • 中文名稱:
    EBF3兔多克隆抗體
  • 貨號(hào):
    CSB-PA007358GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    EBF3
  • 別名:
    COE 3 antibody; COE3 antibody; COE3_HUMAN antibody; Early B cell factor 3 antibody; Early B-cell factor 3 antibody; EBF 3 antibody; EBF-3 antibody; EBF3 antibody; O/E 2 antibody; O/E-2 antibody; O/E2 antibody; OE 2 antibody; OE-2 antibody; OE2 antibody; Olf 1/EBF like 2 antibody; Olf-1/EBF-like 2 antibody; Transcription factor COE3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human EBF3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Transcriptional activator. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
  • 基因功能參考文獻(xiàn):
    1. Data show that early B-cell factor 3 (EBF3) was identified as the direct downstream target gene of miR-23b-3p. PMID: 29750239
    2. Associations of Pulmonary Fibrosis with Peripheral Blood Th1/Th2 Cell Imbalance and EBF3 Gene Methylation in Uygur Pigeon Breeder's Lung Patients. PMID: 29913442
    3. Results found that hypermethylation of the EBF3 promoter was associated with increased EBF3 mRNA levels in metastatic melanomas and subsequent inhibition of DNA methylation reduced EBF3 expression, suggesting that EBF3 promoter hypermethylation may be a candidate epigenetic driver of metastasis. PMID: 28030832
    4. In 11 affected individuals from 11 unrelated families, we identified de novo variants in EBF3 as potentially causative for the neurodevelopmental phenotype. The variants include one nonsense, two frameshift deletions, one splice, and three missense variants. There are three de novo missense variants, (p.(Lys64Thr), p.(His157Gln), and p.(Arg209Gln), which are all in the COE1 DNA-binding domain. PMID: 29162653
    5. EBF3, a transcription factor previously unknown to be associated with human disease, is important for brain and other organ development and warrants further investigation PMID: 28017370
    6. findings indicate that mutations in EBF3 cause a genetic neurodevelopmental syndrome and suggest that loss of EBF3 function might mediate a subset of neurologic phenotypes shared by ARX-related disorders, including intellectual disability, abnormal genitalia, and structural CNS malformations PMID: 28017372
    7. findings demonstrate that variants disrupting EBF3-mediated transcriptional regulation cause intellectual disability and developmental delay and are present in approximately 0.1% of individuals with unexplained neurodevelopmental disorders PMID: 28017373
    8. Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia PMID: 25609158
    9. EBF3 tumor suppressor is epigenetically silenced and that it serves as an independent prognostic marker in gastric carcinoma. PMID: 21387304
    10. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. PMID: 20029986
    11. Findings suggested that the transfection of EBF3 gene into HepG2 induced the cell proliferation from G1 phase to G2 phase by increasing the number of cells. PMID: 18845077
    12. Expression of EBF3 resulted in cell cycle arrest and apoptosis. EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway. PMID: 17018599
    13. Frequent methylation of EBF3 gene is associated with head and neck squamous cell carcinoma PMID: 18559491

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Hypotonia, ataxia, and delayed development syndrome (HADDS)
  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    COE family
  • 組織特異性:
    Expressed in brain.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 19087

    OMIM: 607407

    KEGG: hsa:253738

    UniGene: Hs.591374



主站蜘蛛池模板: 蜜臀av在线无码国产| 一区二区三区在线 | 欧| 丰满人妻被公侵犯高清版| 国产h视频在线观看| 青草影院内射中出高潮| 亚洲欧洲日产国产 最新| 亚洲精品中国国产嫩草影院美女 | 国产手机在线无码播放视频| 亚洲人成网7777777国产| 精品欧洲av无码一区二区| 日日拍夜夜嗷嗷叫国产| 日产乱码一区二区三区在线| 人人莫人人擦人人看| 国精产品一区一区三区mba下载| 色综合99久久久无码国产精品| 亚洲中文字幕久久精品无码va| 亚洲va欧美va国产va综合| 国产精品一卡二卡三卡四卡| 兔费看少妇性l交大片免费| 久久精品99av高久久精品| 亚洲日韩中文字幕在线不卡最新 | 国产精品av免费观看| 丁香五月亚洲综合深深爱| 色视频综合无码一区二区三区 | 国产精品亚洲lv粉色| 色情久久久av熟女人妻网站| 男女无遮挡猛进猛出免费观看视频| 色琪琪丁香婷婷综合久久| 国模吧无码一区二区三区| 国产影片中文字幕| 国产情侣激情在线视频| 爽到高潮无码视频在线观看| 久久国语露脸国产精品电影| 亚洲精品久久久一二三区| 综合 欧美 小说 另类 图| 蜜臀av无码精品人妻色欲| 精品久久久久久无码专区| 色老头精品午夜福利视频| 亚洲熟妇无码另类久久久| 好大好湿好硬顶到了好爽视频| 免费观看国产小粉嫩喷水|