在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EBF3 Antibody, Biotin conjugated

  • 中文名稱:
    EBF3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA880977LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EBF3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EBF3
  • 別名:
    COE 3 antibody; COE3 antibody; COE3_HUMAN antibody; Early B cell factor 3 antibody; Early B-cell factor 3 antibody; EBF 3 antibody; EBF-3 antibody; EBF3 antibody; O/E 2 antibody; O/E-2 antibody; O/E2 antibody; OE 2 antibody; OE-2 antibody; OE2 antibody; Olf 1/EBF like 2 antibody; Olf-1/EBF-like 2 antibody; Transcription factor COE3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transcription factor COE3 protein (416-530AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional activator. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
  • 基因功能參考文獻:
    1. Data show that early B-cell factor 3 (EBF3) was identified as the direct downstream target gene of miR-23b-3p. PMID: 29750239
    2. Associations of Pulmonary Fibrosis with Peripheral Blood Th1/Th2 Cell Imbalance and EBF3 Gene Methylation in Uygur Pigeon Breeder's Lung Patients. PMID: 29913442
    3. Results found that hypermethylation of the EBF3 promoter was associated with increased EBF3 mRNA levels in metastatic melanomas and subsequent inhibition of DNA methylation reduced EBF3 expression, suggesting that EBF3 promoter hypermethylation may be a candidate epigenetic driver of metastasis. PMID: 28030832
    4. In 11 affected individuals from 11 unrelated families, we identified de novo variants in EBF3 as potentially causative for the neurodevelopmental phenotype. The variants include one nonsense, two frameshift deletions, one splice, and three missense variants. There are three de novo missense variants, (p.(Lys64Thr), p.(His157Gln), and p.(Arg209Gln), which are all in the COE1 DNA-binding domain. PMID: 29162653
    5. EBF3, a transcription factor previously unknown to be associated with human disease, is important for brain and other organ development and warrants further investigation PMID: 28017370
    6. findings indicate that mutations in EBF3 cause a genetic neurodevelopmental syndrome and suggest that loss of EBF3 function might mediate a subset of neurologic phenotypes shared by ARX-related disorders, including intellectual disability, abnormal genitalia, and structural CNS malformations PMID: 28017372
    7. findings demonstrate that variants disrupting EBF3-mediated transcriptional regulation cause intellectual disability and developmental delay and are present in approximately 0.1% of individuals with unexplained neurodevelopmental disorders PMID: 28017373
    8. Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia PMID: 25609158
    9. EBF3 tumor suppressor is epigenetically silenced and that it serves as an independent prognostic marker in gastric carcinoma. PMID: 21387304
    10. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. PMID: 20029986
    11. Findings suggested that the transfection of EBF3 gene into HepG2 induced the cell proliferation from G1 phase to G2 phase by increasing the number of cells. PMID: 18845077
    12. Expression of EBF3 resulted in cell cycle arrest and apoptosis. EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway. PMID: 17018599
    13. Frequent methylation of EBF3 gene is associated with head and neck squamous cell carcinoma PMID: 18559491

    顯示更多

    收起更多

  • 相關疾病:
    Hypotonia, ataxia, and delayed development syndrome (HADDS)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    COE family
  • 組織特異性:
    Expressed in brain.
  • 數據庫鏈接:

    HGNC: 19087

    OMIM: 607407

    KEGG: hsa:253738

    UniGene: Hs.591374



主站蜘蛛池模板: 久久精品久久久久观看99水蜜桃| 国产一卡2卡3卡四卡精品国色无边| 天天鲁在视频在线观看| 国产精品亚洲色婷婷99久久精品 | 老司机午夜福利av无码特黄a| 色国产精品一区在线观看| 国产人妻黑人一区二区三区 | 国语对白嫖老妇胖老太| 极品老师腿张开粉嫩小泬| 欧美精品亚洲精品日韩传电影| 国产精品无码日韩欧| 国产+成+人+亚洲欧洲自线| 国产美女裸体无遮挡免费视频 | 国产麻豆剧传媒精品国产av | 亚洲精品国产suv一区88| 人人超碰人摸人爱| 国模无码人体一区二区| 亚洲精品一区二区精华液| 免费无码av一区二区三区| 国产精品久久久久影院嫩草| 亚洲电影天堂av2017| 精品伊人久久久大香线蕉下载| 亚洲精品人成无码中文毛片| 欧美破苞系列二十三| 2021最新精品国自产拍视频| 男女啪啪高潮无遮挡免费| 欧美成人免费一区二区| 久久免费精品国产72精品| 人妻无码系列一区二区三区| 欧美寡妇xxxx黑人猛交| 麻豆国产97在线 | 欧美| 久久久国产99久久国产久麻豆| 狠狠做五月深爱婷婷| 精品久久国产字幕高潮| 亚洲精品无码一二区a片| 国产福利一区二区麻豆| 亚洲国产av美女网站| 图片区小说区激情区偷拍区| 国产婷婷精品av在线| 狠狠色噜噜狠狠狠888米奇| 色综合久久无码中文字幕|