在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EBF3 Antibody, Biotin conjugated

  • 中文名稱:
    EBF3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA880977LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EBF3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EBF3
  • 別名:
    COE 3 antibody; COE3 antibody; COE3_HUMAN antibody; Early B cell factor 3 antibody; Early B-cell factor 3 antibody; EBF 3 antibody; EBF-3 antibody; EBF3 antibody; O/E 2 antibody; O/E-2 antibody; O/E2 antibody; OE 2 antibody; OE-2 antibody; OE2 antibody; Olf 1/EBF like 2 antibody; Olf-1/EBF-like 2 antibody; Transcription factor COE3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transcription factor COE3 protein (416-530AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional activator. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
  • 基因功能參考文獻:
    1. Data show that early B-cell factor 3 (EBF3) was identified as the direct downstream target gene of miR-23b-3p. PMID: 29750239
    2. Associations of Pulmonary Fibrosis with Peripheral Blood Th1/Th2 Cell Imbalance and EBF3 Gene Methylation in Uygur Pigeon Breeder's Lung Patients. PMID: 29913442
    3. Results found that hypermethylation of the EBF3 promoter was associated with increased EBF3 mRNA levels in metastatic melanomas and subsequent inhibition of DNA methylation reduced EBF3 expression, suggesting that EBF3 promoter hypermethylation may be a candidate epigenetic driver of metastasis. PMID: 28030832
    4. In 11 affected individuals from 11 unrelated families, we identified de novo variants in EBF3 as potentially causative for the neurodevelopmental phenotype. The variants include one nonsense, two frameshift deletions, one splice, and three missense variants. There are three de novo missense variants, (p.(Lys64Thr), p.(His157Gln), and p.(Arg209Gln), which are all in the COE1 DNA-binding domain. PMID: 29162653
    5. EBF3, a transcription factor previously unknown to be associated with human disease, is important for brain and other organ development and warrants further investigation PMID: 28017370
    6. findings indicate that mutations in EBF3 cause a genetic neurodevelopmental syndrome and suggest that loss of EBF3 function might mediate a subset of neurologic phenotypes shared by ARX-related disorders, including intellectual disability, abnormal genitalia, and structural CNS malformations PMID: 28017372
    7. findings demonstrate that variants disrupting EBF3-mediated transcriptional regulation cause intellectual disability and developmental delay and are present in approximately 0.1% of individuals with unexplained neurodevelopmental disorders PMID: 28017373
    8. Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia PMID: 25609158
    9. EBF3 tumor suppressor is epigenetically silenced and that it serves as an independent prognostic marker in gastric carcinoma. PMID: 21387304
    10. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. PMID: 20029986
    11. Findings suggested that the transfection of EBF3 gene into HepG2 induced the cell proliferation from G1 phase to G2 phase by increasing the number of cells. PMID: 18845077
    12. Expression of EBF3 resulted in cell cycle arrest and apoptosis. EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway. PMID: 17018599
    13. Frequent methylation of EBF3 gene is associated with head and neck squamous cell carcinoma PMID: 18559491

    顯示更多

    收起更多

  • 相關疾病:
    Hypotonia, ataxia, and delayed development syndrome (HADDS)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    COE family
  • 組織特異性:
    Expressed in brain.
  • 數據庫鏈接:

    HGNC: 19087

    OMIM: 607407

    KEGG: hsa:253738

    UniGene: Hs.591374



主站蜘蛛池模板: 国产激情视频一区二区三区| 人与性动交aaaabbbb| 亚洲视频在线观看| 亚洲处破女av日韩精品| 涩里番网污站| 日韩好精品视频你懂的| 18禁在线永久免费观看| 亚洲国产精品无码专区| 果冻传媒一区二区天美传媒| 成人av无码国产在线观看| 国产看黄网站又黄又爽又色| 免费午夜无码片在线观看影院| 精品久久久无码中文字幕一丶| 一本久道综合色婷婷五月| 久久久久免费精品国产| 色偷偷88888欧美精品久久久| 久久久久国产精品| 免费国产在线精品一区不卡| 亚洲人成网站在小说| 国内少妇毛片视频| 狠狠色噜噜狠狠狠狠888奇禾| 亚洲大片av毛片免费| 国产成年无码v片在线| 男人扒开添女人下部免费视频| 国产在线无码一区二区三区| 国产av无码专区影视| 欧美另类videosbestsex日本| 国产成人精品成人a在线观看| 真实国产乱子伦在线视频| 无码熟妇人妻av在线电影| 国产欧美日韩精品a在线观看| 好男人日本社区www| 丰满少妇aaaaaa爰片毛片| 在线观看国产亚洲视频免费 | 97se狼狼狼狼狼亚洲网| 成人午夜福利视频| 免费无码又爽又刺激高潮视频| 国产超薄肉色丝袜视频| 欧美人与动性行为视频| 人人妻人人澡人人爽秒播| 精品久久久久久无码专区|