在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

EBF3 Antibody, Biotin conjugated

  • 中文名稱:
    EBF3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA880977LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) EBF3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    EBF3
  • 別名:
    COE 3 antibody; COE3 antibody; COE3_HUMAN antibody; Early B cell factor 3 antibody; Early B-cell factor 3 antibody; EBF 3 antibody; EBF-3 antibody; EBF3 antibody; O/E 2 antibody; O/E-2 antibody; O/E2 antibody; OE 2 antibody; OE-2 antibody; OE2 antibody; Olf 1/EBF like 2 antibody; Olf-1/EBF-like 2 antibody; Transcription factor COE3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Transcription factor COE3 protein (416-530AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional activator. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
  • 基因功能參考文獻:
    1. Data show that early B-cell factor 3 (EBF3) was identified as the direct downstream target gene of miR-23b-3p. PMID: 29750239
    2. Associations of Pulmonary Fibrosis with Peripheral Blood Th1/Th2 Cell Imbalance and EBF3 Gene Methylation in Uygur Pigeon Breeder's Lung Patients. PMID: 29913442
    3. Results found that hypermethylation of the EBF3 promoter was associated with increased EBF3 mRNA levels in metastatic melanomas and subsequent inhibition of DNA methylation reduced EBF3 expression, suggesting that EBF3 promoter hypermethylation may be a candidate epigenetic driver of metastasis. PMID: 28030832
    4. In 11 affected individuals from 11 unrelated families, we identified de novo variants in EBF3 as potentially causative for the neurodevelopmental phenotype. The variants include one nonsense, two frameshift deletions, one splice, and three missense variants. There are three de novo missense variants, (p.(Lys64Thr), p.(His157Gln), and p.(Arg209Gln), which are all in the COE1 DNA-binding domain. PMID: 29162653
    5. EBF3, a transcription factor previously unknown to be associated with human disease, is important for brain and other organ development and warrants further investigation PMID: 28017370
    6. findings indicate that mutations in EBF3 cause a genetic neurodevelopmental syndrome and suggest that loss of EBF3 function might mediate a subset of neurologic phenotypes shared by ARX-related disorders, including intellectual disability, abnormal genitalia, and structural CNS malformations PMID: 28017372
    7. findings demonstrate that variants disrupting EBF3-mediated transcriptional regulation cause intellectual disability and developmental delay and are present in approximately 0.1% of individuals with unexplained neurodevelopmental disorders PMID: 28017373
    8. Early B-cell factor 3 (EBF3) is a novel tumor suppressor gene with promoter hypermethylation in pediatric acute myeloid leukemia PMID: 25609158
    9. EBF3 tumor suppressor is epigenetically silenced and that it serves as an independent prognostic marker in gastric carcinoma. PMID: 21387304
    10. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. PMID: 20029986
    11. Findings suggested that the transfection of EBF3 gene into HepG2 induced the cell proliferation from G1 phase to G2 phase by increasing the number of cells. PMID: 18845077
    12. Expression of EBF3 resulted in cell cycle arrest and apoptosis. EBF3 regulates a transcriptional program underlying a putative tumor suppression pathway. PMID: 17018599
    13. Frequent methylation of EBF3 gene is associated with head and neck squamous cell carcinoma PMID: 18559491

    顯示更多

    收起更多

  • 相關疾病:
    Hypotonia, ataxia, and delayed development syndrome (HADDS)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    COE family
  • 組織特異性:
    Expressed in brain.
  • 數據庫鏈接:

    HGNC: 19087

    OMIM: 607407

    KEGG: hsa:253738

    UniGene: Hs.591374



主站蜘蛛池模板: 国产日韩综合av在线观看一区| 久久综合久久鬼色| 99j久久精品久久久久久| 久久和欧洲码一码二码三码| 国产成人av大片在线播放| 成人综合婷婷国产精品久久蜜臀| 亚洲综合一区无码精品| 亚洲国产午夜精品理论片妓女| 日本成a人片在线播放| 无码视频一区二区三区在线观看| 三上悠亚人妻中文字幕在线| 又黄又硬又湿又刺激视频免费| 亚洲伊人色欲综合网无码中文| 天天爽夜夜爽人人爽曰| 山东熟女啪啪哦哦叫| 久久97久久97精品免视看秋霞| 国产日韩在线观看不卡顿| 理论片午午伦夜理片影院99| 天天狠天天天天透在线| 欧美日韩亚洲tv不卡久久| 高清一区二区三区免费视频| 情人伊人久久综合亚洲| 久久中文字幕人妻av熟女| 西西艺术人像摄影| 亚洲 日本 欧美 中文幕| 国产97在线 | 免费| 日本免费一区二区三区日本| 中文字幕亚洲综合久久青草| 97精品人人a片免费看| 色喜国模李晴超大尺度| 女人摸下面自熨视频在线播放| 久久综合九色综合97欧美| 国产日产欧洲无码视频| 成人毛片av免费| 亚洲一卡二卡三卡四卡无卡麻豆| 国产精品久久久久久一区二区三区| 中文字幕亚洲制服在线看| 人妻天天爽夜夜爽精品视频| 国产亚洲精品欧洲在线观看 | 在线 国产 精品 蜜芽| 无码人妻丰满熟妇啪啪欧美|