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DUSP26 Antibody

  • 中文名稱:
    DUSP26兔多克隆抗體
  • 貨號(hào):
    CSB-PA940977
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA940977(DUSP26 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA940977(DUSP26 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    DUSP26
  • 別名:
    DSP-4 antibody; Dual specificity phosphatase 26 (putative) antibody; Dual specificity phosphatase 26 antibody; Dual specificity phosphatase SKRP3 antibody; Dual specificity protein phosphatase 26 antibody; DUS26_HUMAN antibody; DUSP24 antibody; DUSP26 antibody; Hypothetical protein FLJ31142 antibody; LDP 4 antibody; LDP-4 antibody; Low molecular mass dual specificity phosphatase 4 antibody; Low-molecular-mass dual-specificity phosphatase 4 antibody; MAP kinase phosphatase 8 antibody; MGC1136 antibody; MGC2627 antibody; Mitogen activated protein kinase phosphatase 8 antibody; Mitogen-activated protein kinase phosphatase 8 antibody; MKP-8 antibody; MKP8 antibody; NATA1 antibody; NATA1 protein antibody; Novel amplified gene in thyroid anaplastic cancer antibody; SKRP3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human DUSP26
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
  • 基因功能參考文獻(xiàn):
    1. Enhanced expression of DUSP26 was observed in the hippocampus of Alzheimer's disease patients. PMID: 26924229
    2. results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth. PMID: 24548998
    3. The study reports the 1.68 A crystal structure of a catalytically inactive mutant (Cys152Ser) of DUSP26 lacking the first 60 N-terminal residues (DeltaN60-C/S-DUSP26). PMID: 23298255
    4. DUSP26 may function as a tumour suppressor in particular cancers. PMID: 20347885
    5. DUSP26 functions as a p53 phosphatase PMID: 20562916
    6. DUSP26 effectively dephosphorylates p38 and has a little effect on extracellular signal-regulated kinase in anaplastic thyroid cancer. PMID: 16924234
    7. Downregulation of Dusp26 may contribute to malignant phenotypes of glioma. PMID: 19043453

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  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus. Golgi apparatus.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 組織特異性:
    Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 28161

    KEGG: hsa:78986

    STRING: 9606.ENSP00000256261

    UniGene: Hs.8719



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