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  4. DUSP26 Antibody

DUSP26 Antibody

  • 中文名稱：
    DUSP26兔多克隆抗體
  • 貨號：
    CSB-PA863128LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA863128LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA863128LA01HU at dilution of 1:100
    • Immunofluorescence staining of SH-SY5Y cells with CSB-PA863128LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) DUSP26 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DUSP26
  • 別名：
    DSP-4 antibody; Dual specificity phosphatase 26 (putative) antibody; Dual specificity phosphatase 26 antibody; Dual specificity phosphatase SKRP3 antibody; Dual specificity protein phosphatase 26 antibody; DUS26_HUMAN antibody; DUSP24 antibody; DUSP26 antibody; Hypothetical protein FLJ31142 antibody; LDP 4 antibody; LDP-4 antibody; Low molecular mass dual specificity phosphatase 4 antibody; Low-molecular-mass dual-specificity phosphatase 4 antibody; MAP kinase phosphatase 8 antibody; MGC1136 antibody; MGC2627 antibody; Mitogen activated protein kinase phosphatase 8 antibody; Mitogen-activated protein kinase phosphatase 8 antibody; MKP-8 antibody; MKP8 antibody; NATA1 antibody; NATA1 protein antibody; Novel amplified gene in thyroid anaplastic cancer antibody; SKRP3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Dual specificity protein phosphatase 26 protein (1-211AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，DUSP26 Antibody (CSB-PA863128LA01HU)，的標記方式是Non-conjugated。對于DUSP26 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA863128LB01HU DUSP26 Antibody, HRP conjugated ELISA
    FITC CSB-PA863128LC01HU DUSP26 Antibody, FITC conjugated
    Biotin CSB-PA863128LD01HU DUSP26 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
  • 基因功能參考文獻：
    1. Enhanced expression of DUSP26 was observed in the hippocampus of Alzheimer's disease patients. PMID: 26924229
    2. results suggest that AK2 is an associated activator of DUSP26 and suppresses cell proliferation by FADD dephosphorylation, postulating AK2 as a negative regulator of tumour growth. PMID: 24548998
    3. The study reports the 1.68 A crystal structure of a catalytically inactive mutant (Cys152Ser) of DUSP26 lacking the first 60 N-terminal residues (DeltaN60-C/S-DUSP26). PMID: 23298255
    4. DUSP26 may function as a tumour suppressor in particular cancers. PMID: 20347885
    5. DUSP26 functions as a p53 phosphatase PMID: 20562916
    6. DUSP26 effectively dephosphorylates p38 and has a little effect on extracellular signal-regulated kinase in anaplastic thyroid cancer. PMID: 16924234
    7. Downregulation of Dusp26 may contribute to malignant phenotypes of glioma. PMID: 19043453

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Golgi apparatus.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 組織特異性：
    Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
  • 數據庫鏈接：

    HGNC: 28161

    KEGG: hsa:78986

    STRING: 9606.ENSP00000256261

    UniGene: Hs.8719



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