在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DDX4 Antibody

  • 中文名稱:
    DDX4兔多克隆抗體
  • 貨號:
    CSB-PA006623GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    DDX 4 antibody; Ddx4 antibody; DDX4_HUMAN antibody; DEAD (Asp Glu Ala Asp) box polypeptide 4 antibody; DEAD box protein 4 antibody; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4 antibody; MVH antibody; Probable ATP dependent RNA helicase DDX4 antibody; Probable ATP-dependent RNA helicase DDX4 antibody; VASA antibody; Vasa homolog antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Human DDX4,VASA
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs.
  • 基因功能參考文獻(xiàn):
    1. Four sterility-related genes, including BOLL, DDX4, HORMAD1, and MAEL, were found to have increased methylation at CpGs of the promoter regions and decreased mRNA expressions in nonobstructive azoospermia and hypospermatogenesis (HS) testis and are believed to be associated with HS. PMID: 28342926
    2. positivity for DDX4 gene was detected in 17 of 39 males with nonobstructive azoospermia which was due to maturation arrest in 35.3% of cases, due to incomplete Sertoli cell only in 23.5% and due to complete Sertoli cell only in 41.2%. PMID: 28000927
    3. Results suggest that DDX4 positively regulates cell cycle progression of diverse somatic-derived blood cancer cells, implying its broad contributions to the cancer cell phenotype. PMID: 28612512
    4. DDX4 cell-free seminal mRNA was absent in 44% of Sertoli cell-only syndrome cases diagnosed by testicular histopathology, but present in all patients presenting with maturation arrest or hypospermatogenesis PMID: 27211570
    5. The 20-mer peptide (residues 228-247) of human DDX-4, an ATP-dependent RNA helicase known to regulate germ cell development, binds to a unique shallow binding surface on RanBPM formed by highly conserved loops on the surface of the beta-sheet with two aspartates on one end, a positive patch on the opposite end, and a tryptophan lining at the bottom of the surface. PMID: 27622290
    6. Data show that intrinsically disordered N terminus of DEAD-box RNA helicase Ddx4 forms organelles in HeLa cells and in vitro. PMID: 25747659
    7. this study reports the first analysis and comparison of the expression patterns and colocalization of DDX4 and CD133 in 59 ovarian cancer patients via tissue microarray and immunofluorescence analysis to identify the expression patterns and relationship of those two markers in ovarian cancer cells. PMID: 24727449
    8. Data suggest that VASA shows differential expression in ovary; in resting primordial follicle reserve in childhood/pre-puberty, VASA is associated with Balbiani's body space in germ cell; once follicle enters growing pool, VASA is undetectable. PMID: 23315064
    9. Vasa/Ddx4 gene can be involved in regulation of ground and primed states of pluripotency PMID: 22288104
    10. overexpression of VASA and or DAZL, in both embryonic and induced pluripotent stem cells promoted differentiation into primordial germ cells, and maturation and progression through meiosis was enhanced. PMID: 22162380
    11. Report the generation/characterization of embryonic stem cell lines carrying a VASA-pEGFP-1 reporter construct that expresses GFP in a population of differentiating cells showing expression of characteristic markers of primordial germ cells. PMID: 19937754
    12. marker for normal and malignant germ cells PMID: 11850529
    13. The expression of VASA mRNA and protein was significantly decreased in the sperm of oligozoospermic men. PMID: 17486274
    14. VASA showed a differential pattern of expression throughout the differentiation and proliferative phase and prophase I to finally associate with Balbiani's body in primordial and primary follicles. PMID: 18534994
    15. Over-expression of VASA abrogates the G2 checkpoint, induced by DNA damage, by down-regulating the expression of 14-3-3sigma. Results suggest that VASA may play a role in the progression of ovarian cancer or serve as a valuable marker of tumorigenesis. PMID: 18805576
    16. Highly methylated regions of the VASA gene are associated with maturation arrest phenotype in the testis. PMID: 19629140

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族:
    DEAD box helicase family, DDX4/VASA subfamily
  • 組織特異性:
    Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18700

    OMIM: 605281

    KEGG: hsa:54514

    STRING: 9606.ENSP00000424838

    UniGene: Hs.223581



主站蜘蛛池模板: 国产精品一区二区久久乐下载| 51国偷自产一区二区三区| 久久天天躁狠狠躁夜夜躁2014| 国产欧美日韩综合视频专区| 一本色道久久综合亚州精品蜜桃| 色琪琪av中文字幕一区二区| 精品国内在视频线2019| 精品久久久久久久免费人妻| 亚洲第一最快av网站| 一区二区三区毛aaaa片特级| 国产真实老熟女无套内射| 国产区女主播在线观看| 日本精品αv中文字幕| 无码人妻天天拍夜夜爽| 亚洲精品国偷拍自产在线观看蜜桃| 丰满人妻熟妇乱又伦精品软件| 在线亚洲精品国产一区麻豆| 手机看片精品国产福利| 一本色道久久88加勒比—综合| 色悠久久久久久久综合网伊人| 日本久久综合久久综合| 天堂网在线www中文| 伊人成色综合网| 午夜片神马影院福利| 久久无码高潮喷水抽搐| 国产成人久久av免费| 国产精品亚洲lv粉色| 无码国产偷倩在线播放| 韩国 日本 亚洲 国产 不卡| 日日鲁鲁鲁夜夜爽爽狠狠视频97| 国产日韩综合一区二区性色av| 99精品视频一区在线观看| 国产高清在线精品一区下载| 国产精品51麻豆cm传媒| 免费无码一区二区三区蜜桃大 | 97香蕉碰碰人妻国产欧美| 免费女人高潮流视频在线| 尤物tv国产精品看片在线| 无码丰满熟妇juliaann与黑人| 妇女性内射冈站hdwww000| 无码午夜福利视频1000集|