在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DDX4 Antibody, HRP conjugated

  • 中文名稱:
    DDX4兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA882074LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DDX4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DDX 4 antibody; Ddx4 antibody; DDX4_HUMAN antibody; DEAD (Asp Glu Ala Asp) box polypeptide 4 antibody; DEAD box protein 4 antibody; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 4 antibody; MVH antibody; Probable ATP dependent RNA helicase DDX4 antibody; Probable ATP-dependent RNA helicase DDX4 antibody; VASA antibody; Vasa homolog antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Probable ATP-dependent RNA helicase DDX4 protein (1-223AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs.
  • 基因功能參考文獻:
    1. Four sterility-related genes, including BOLL, DDX4, HORMAD1, and MAEL, were found to have increased methylation at CpGs of the promoter regions and decreased mRNA expressions in nonobstructive azoospermia and hypospermatogenesis (HS) testis and are believed to be associated with HS. PMID: 28342926
    2. positivity for DDX4 gene was detected in 17 of 39 males with nonobstructive azoospermia which was due to maturation arrest in 35.3% of cases, due to incomplete Sertoli cell only in 23.5% and due to complete Sertoli cell only in 41.2%. PMID: 28000927
    3. Results suggest that DDX4 positively regulates cell cycle progression of diverse somatic-derived blood cancer cells, implying its broad contributions to the cancer cell phenotype. PMID: 28612512
    4. DDX4 cell-free seminal mRNA was absent in 44% of Sertoli cell-only syndrome cases diagnosed by testicular histopathology, but present in all patients presenting with maturation arrest or hypospermatogenesis PMID: 27211570
    5. The 20-mer peptide (residues 228-247) of human DDX-4, an ATP-dependent RNA helicase known to regulate germ cell development, binds to a unique shallow binding surface on RanBPM formed by highly conserved loops on the surface of the beta-sheet with two aspartates on one end, a positive patch on the opposite end, and a tryptophan lining at the bottom of the surface. PMID: 27622290
    6. Data show that intrinsically disordered N terminus of DEAD-box RNA helicase Ddx4 forms organelles in HeLa cells and in vitro. PMID: 25747659
    7. this study reports the first analysis and comparison of the expression patterns and colocalization of DDX4 and CD133 in 59 ovarian cancer patients via tissue microarray and immunofluorescence analysis to identify the expression patterns and relationship of those two markers in ovarian cancer cells. PMID: 24727449
    8. Data suggest that VASA shows differential expression in ovary; in resting primordial follicle reserve in childhood/pre-puberty, VASA is associated with Balbiani's body space in germ cell; once follicle enters growing pool, VASA is undetectable. PMID: 23315064
    9. Vasa/Ddx4 gene can be involved in regulation of ground and primed states of pluripotency PMID: 22288104
    10. overexpression of VASA and or DAZL, in both embryonic and induced pluripotent stem cells promoted differentiation into primordial germ cells, and maturation and progression through meiosis was enhanced. PMID: 22162380
    11. Report the generation/characterization of embryonic stem cell lines carrying a VASA-pEGFP-1 reporter construct that expresses GFP in a population of differentiating cells showing expression of characteristic markers of primordial germ cells. PMID: 19937754
    12. marker for normal and malignant germ cells PMID: 11850529
    13. The expression of VASA mRNA and protein was significantly decreased in the sperm of oligozoospermic men. PMID: 17486274
    14. VASA showed a differential pattern of expression throughout the differentiation and proliferative phase and prophase I to finally associate with Balbiani's body in primordial and primary follicles. PMID: 18534994
    15. Over-expression of VASA abrogates the G2 checkpoint, induced by DNA damage, by down-regulating the expression of 14-3-3sigma. Results suggest that VASA may play a role in the progression of ovarian cancer or serve as a valuable marker of tumorigenesis. PMID: 18805576
    16. Highly methylated regions of the VASA gene are associated with maturation arrest phenotype in the testis. PMID: 19629140

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族:
    DEAD box helicase family, DDX4/VASA subfamily
  • 組織特異性:
    Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.
  • 數據庫鏈接:

    HGNC: 18700

    OMIM: 605281

    KEGG: hsa:54514

    STRING: 9606.ENSP00000424838

    UniGene: Hs.223581



主站蜘蛛池模板: 99热精品国自产拍天天拍| 噜噜色综合噜噜色噜噜色| 大肉大捧一进一出好爽视频| 五月婷婷俺也去开心| 亚洲人成小说网站色在线| 老色鬼永久视频网站| 综合欧美日韩国产成人| 成人毛片18女人毛片免费| 亚洲最大天堂无码精品区| 国产精成人品| 狠狠色噜噜狠狠狠狠蜜桃| 亚洲男人的天堂在线aⅴ视频| 国产一区二区三区在线观看| 中文字幕无线码免费人妻| 亚洲精品1卡2卡三卡4卡乱码| 午夜爽爽爽男女污污污网站| 国产男女免费完整视频在线 | 久久亚洲春色中文字幕久久久 | 国产精品毛片完整版视频| 成人av片在线观看免费| 亚洲欧美日韩在线一区| 澳门永久av免费网站| 久久综合色鬼综合色| 卡1卡2卡3精品接入口| 日韩亚洲国产高清免费视频| 亚洲成av人的天堂在线观看| 久久久久久a亚洲欧洲av| 久久久久久久岛国免费观看| 国产精品白丝av网站| 欧美交换国产一区内射| 国产精品亚洲lv粉色| 国产喷水1区2区3区咪咪爱av| 亚洲中文无码av永久伊人| 欧美性猛交久久久乱大交小说| 国产精品99久久免费黑人人妻| 在线观看无码不卡av中文| 亚洲精品av网站在线观看| 在线成人一区二区| 小sao货水好多真紧h无码视频| 国产人妻精品区一区二区三区| 国产美女遭强高潮网站下载|