在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

DDX4 Antibody

  • 中文名稱:
    DDX4兔多克隆抗體
  • 貨號:
    CSB-PA777607
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from Hela, K562 and 3T3 cells using DDX4 Antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) DDX4 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Peptide sequence around aa.273~277(T-I-L-V-E)derived from Human DDX4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs.
  • 基因功能參考文獻:
    1. Four sterility-related genes, including BOLL, DDX4, HORMAD1, and MAEL, were found to have increased methylation at CpGs of the promoter regions and decreased mRNA expressions in nonobstructive azoospermia and hypospermatogenesis (HS) testis and are believed to be associated with HS. PMID: 28342926
    2. positivity for DDX4 gene was detected in 17 of 39 males with nonobstructive azoospermia which was due to maturation arrest in 35.3% of cases, due to incomplete Sertoli cell only in 23.5% and due to complete Sertoli cell only in 41.2%. PMID: 28000927
    3. Results suggest that DDX4 positively regulates cell cycle progression of diverse somatic-derived blood cancer cells, implying its broad contributions to the cancer cell phenotype. PMID: 28612512
    4. DDX4 cell-free seminal mRNA was absent in 44% of Sertoli cell-only syndrome cases diagnosed by testicular histopathology, but present in all patients presenting with maturation arrest or hypospermatogenesis PMID: 27211570
    5. The 20-mer peptide (residues 228-247) of human DDX-4, an ATP-dependent RNA helicase known to regulate germ cell development, binds to a unique shallow binding surface on RanBPM formed by highly conserved loops on the surface of the beta-sheet with two aspartates on one end, a positive patch on the opposite end, and a tryptophan lining at the bottom of the surface. PMID: 27622290
    6. Data show that intrinsically disordered N terminus of DEAD-box RNA helicase Ddx4 forms organelles in HeLa cells and in vitro. PMID: 25747659
    7. this study reports the first analysis and comparison of the expression patterns and colocalization of DDX4 and CD133 in 59 ovarian cancer patients via tissue microarray and immunofluorescence analysis to identify the expression patterns and relationship of those two markers in ovarian cancer cells. PMID: 24727449
    8. Data suggest that VASA shows differential expression in ovary; in resting primordial follicle reserve in childhood/pre-puberty, VASA is associated with Balbiani's body space in germ cell; once follicle enters growing pool, VASA is undetectable. PMID: 23315064
    9. Vasa/Ddx4 gene can be involved in regulation of ground and primed states of pluripotency PMID: 22288104
    10. overexpression of VASA and or DAZL, in both embryonic and induced pluripotent stem cells promoted differentiation into primordial germ cells, and maturation and progression through meiosis was enhanced. PMID: 22162380
    11. Report the generation/characterization of embryonic stem cell lines carrying a VASA-pEGFP-1 reporter construct that expresses GFP in a population of differentiating cells showing expression of characteristic markers of primordial germ cells. PMID: 19937754
    12. marker for normal and malignant germ cells PMID: 11850529
    13. The expression of VASA mRNA and protein was significantly decreased in the sperm of oligozoospermic men. PMID: 17486274
    14. VASA showed a differential pattern of expression throughout the differentiation and proliferative phase and prophase I to finally associate with Balbiani's body in primordial and primary follicles. PMID: 18534994
    15. Over-expression of VASA abrogates the G2 checkpoint, induced by DNA damage, by down-regulating the expression of 14-3-3sigma. Results suggest that VASA may play a role in the progression of ovarian cancer or serve as a valuable marker of tumorigenesis. PMID: 18805576
    16. Highly methylated regions of the VASA gene are associated with maturation arrest phenotype in the testis. PMID: 19629140

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族:
    DEAD box helicase family, DDX4/VASA subfamily
  • 組織特異性:
    Expressed only in ovary and testis. Expressed in migratory primordial germ cells in the region of the gonadal ridge in both sexes.
  • 數據庫鏈接:

    HGNC: 18700

    OMIM: 605281

    KEGG: hsa:54514

    STRING: 9606.ENSP00000424838

    UniGene: Hs.223581



主站蜘蛛池模板: 一边吃奶一边做动态图| 韩国三级hd中文字幕叫床 | 欧美极品video粗暴| 国产男女猛烈视频在线观看| 大尺度无遮挡激烈床震网站| 免费国产黄网站在线观看 | 天堂а√在线中文在线| 欧美黑人又粗又硬xxxxx喷水 | 亚洲精品国产精华液| 四虎影视在线影院在线观看| 欧洲精品无码一区二区三区在线播放 | 亚洲成av人片不卡无码久久| 亚洲 欧美 动漫 少妇 自拍| 欧美天天拍在线视频| 国产色无码精品视频免费| 午夜成人理论福利片| 大桥未久亚洲一区二区| 久久免费精品国产72精品九九| 漂亮人妻被中出中文字幕 | 大香伊蕉日本一区二区| 中日韩精品视频在线观看| 日韩精品一区二区三区免费视频| 亚洲午夜无码久久久久蜜臀av| 久久99er6热线精品首页| 久久精品www人人爽人人| 色欲久久久天天天综合网精品| 国产精品高潮呻吟av久久小说| 亚洲精品无码ma在线观看| 国内精品自在自线| 无码精品久久一区二区三区| a毛片免费全部播放| 亚洲丰满熟女一区二区v| 大肉大捧一进一出好爽app| 亚洲精品国产美女久久久| 羞国产在线拍揄自揄视频| 国产内射爽爽大片视频社区在线| 四虎成人精品在永久在线| 欧美人与动性xxxxbbbb| 欧美一区二区三区成人片在线| 国产精品国产成人国产三级| 日韩a人毛片精品无人区乱码|