在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. DDX20 Antibody

DDX20 Antibody

  • 中文名稱：
    DDX20兔多克隆抗體
  • 貨號：
    CSB-PA006796
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using Gemin3 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DDX20
  • 別名：
    Component of gems 3 antibody; DDX 20 antibody; ddx20 antibody; DDX20_HUMAN antibody; DEAD (Asp Glu Ala Asp) box polypeptide 20 antibody; DEAD box protein 20 antibody; DEAD box protein DP 103 antibody; DEAD box protein DP103 antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 103kD antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 20 antibody; DEAD/H BOX 20 antibody; DKFZP434H052 antibody; DP 103 antibody; DP103 antibody; Gemin-3 antibody; Gemin3 antibody; Probable ATP dependent RNA helicase DDX20 antibody; Probable ATP-dependent RNA helicase ddx20 antibody; SMN interacting protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Gemin3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
  • 基因功能參考文獻：
    1. The findings show that DDX20 may promote the progression of prostate cancer through the NF-kappaB pathway. PMID: 27121695
    2. In stage-adjusted analysis, the nominal associations of DDX20-rs197412, PTGS2-rs5275, and HSPA5-rs391957 with DFS were detected. However, after FDR correction none of these polymorphisms remained significantly associated with the survival outcomes PMID: 26064972
    3. DP103 defines metastatic potential of human breast cancers. PMID: 25083991
    4. Impairment of miRNA-140 function due to a deficiency of DDX20, a miRNA machinery component, could lead to hepatocarcinogenesis PMID: 22898998
    5. Gemin3 binds with p53, forming a complex, and plays an anti-apoptotic role by repressing the p53 expression in Saos-2 cells. PMID: 22335944
    6. While DDX20 normally suppresses NF-kappaB activity by regulating NF-kappaB-suppressing miRNA-140 function, this suppressive effect was lost in DDX20-deficient cells. PMID: 22445758
    7. we report that EBNA3C directly interacts with Gemin3 through its C-terminal domains PMID: 22174681
    8. NANOS1-PUMILIO2 complex, together with GEMIN3 and small noncoding RNAs, possibly regulate mRNA translation within the chromatoid body of the human germ cells. PMID: 21800163
    9. Data show that the two motor neuropathy-associated mutant HspB8 forms have abnormally increased binding to Ddx20. PMID: 20157854
    10. utilised a targeted screen to identify mRNA associated with SMN, Gemin2 and Gemin3 in the cytoplasm of a human neuroblastoma cell line, SHSY5Y PMID: 20620147
    11. Gemin3 and Gemin4 function in Sm core assembly and correlate the activity of this pathway with Spinal Muscular Atrophy. PMID: 16301532

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus, gem.
  • 蛋白家族：
    DEAD box helicase family, DDX20 subfamily
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 2743

    OMIM: 606168

    KEGG: hsa:11218

    STRING: 9606.ENSP00000358716

    UniGene: Hs.591405



主站蜘蛛池模板： 日本人妻中文字幕乱码系列| 日本丰满熟妇videossex一| 性强烈的欧美三级视频| 国产午睡沙发被弄醒完整版| 久久精品国产日本波多野结衣| 国产男女猛烈无遮挡免费网站| 欧美真人性野外做爰| 亚洲成av人在线视猫咪| 国产内射一区亚洲| 在线视频观看免费视频18| h肉动漫无码无修6080动漫网| 日日拍夜夜嗷嗷叫|日日摸| 亚洲精品精华液一区二区| 亚洲色无码中文字幕yy51999| 国产精品美女久久久久久| 97人洗澡从澡人人爽人人模| 公与淑婷厨房猛烈进出视频免费| 亚洲色精品aⅴ一区区三区| 强辱丰满人妻hd中文字幕| 欧美性video高清精品| 亚洲狠狠婷婷综合久久久久图片| 熟妇女人妻丰满少妇中文字幕| 国产免费啪嗒啪嗒视频看看 | 伊人久久大香线蕉综合75| 欧美色综合天天久久综合精品| 冲田杏梨av一区二区三区| 国产老太睡小伙子视频| 久久这里精品国产99丫e6| 天堂网www中文在线| 四库影院永久国产精品地址| 中文无码日韩欧| 日本熟妇色xxxxx日本免费看| 中文字幕丝袜精品久久| 正在播放国产乱子伦最新视频 | 女学生14毛片视频片二毛| 精品综合久久久久久8888| 99久久无码一区人妻| 欧美乱码伦视频免费| 久久国产乱子伦精品免费台湾| 一本色道久久hezyo无码| 无码吃奶揉捏奶头高潮视频|