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  4. DCTN2 Antibody

DCTN2 Antibody

  • 中文名稱：
    DCTN2兔多克隆抗體
  • 貨號：
    CSB-PA614427LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA614427LA01HU at dilution of 1:100
    • Immunofluorescence staining of MCF-7 cells with CSB-PA614427LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) DCTN2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    DCTN2
  • 別名：
    50 kD dynein associated polypeptide antibody; 50 kDa dynein associated polypeptide antibody; 50 kDa dynein-associated polypeptide antibody; DCTN-50 antibody; DCTN2 antibody; DCTN2_HUMAN antibody; DCTN50 antibody; dynactin 2 (p50) antibody; dynactin 2 antibody; dynactin complex 50 kD subunit antibody; Dynactin complex 50 kDa subunit antibody; Dynactin subunit 2 antibody; DYNAMITIN antibody; p50 dynamitin antibody; RBP50 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Dynactin subunit 2 protein (1-252AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，DCTN2 Antibody (CSB-PA614427LA01HU)，的標記方式是Non-conjugated。對于DCTN2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA614427LB01HU DCTN2 Antibody, HRP conjugated ELISA
    FITC CSB-PA614427LC01HU DCTN2 Antibody, FITC conjugated
    Biotin CSB-PA614427LD01HU DCTN2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
  • 基因功能參考文獻：
    1. This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. PMID: 26517670
    2. dynamitin is involved in the regulation of Nav1.5 cell-surface density PMID: 25088759
    3. the determinants of p50/DM required for self-oligomerization of the protein and for interactions with other subunits of the dynactin complex PMID: 20463029
    4. Altered levels of Cep135 and p50 by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes. PMID: 14983524
    5. the Sec23p component of the COPII complex directly interacts with the dynactin complex through the carboxy-terminal cargo-binding domain of p150(Glued). PMID: 15580264
    6. DCTN2 is required in the earliest stages of peroxisome biogenesis. PMID: 15813749
    7. study does not support a major role for DCTN2 overexpression in carcinogenesis PMID: 16369996
    8. Data show how dynamitin's different structural domains contribute to its ability to self-associate, interact with dynactin and assemble into a complex with its close binding partner, p24. PMID: 18182012
    9. The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner. PMID: 18782227

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Dynactin subunit 2 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2712

    OMIM: 607376

    KEGG: hsa:10540

    STRING: 9606.ENSP00000408910

    UniGene: Hs.289123



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