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DCTN2 Antibody

  • 中文名稱:
    DCTN2兔多克隆抗體
  • 貨號:
    CSB-PA002220
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of A549 cells using Dynactin 2 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DCTN2
  • 別名:
    50 kD dynein associated polypeptide antibody; 50 kDa dynein associated polypeptide antibody; 50 kDa dynein-associated polypeptide antibody; DCTN-50 antibody; DCTN2 antibody; DCTN2_HUMAN antibody; DCTN50 antibody; dynactin 2 (p50) antibody; dynactin 2 antibody; dynactin complex 50 kD subunit antibody; Dynactin complex 50 kDa subunit antibody; Dynactin subunit 2 antibody; DYNAMITIN antibody; p50 dynamitin antibody; RBP50 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human Dynactin 2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
  • 基因功能參考文獻:
    1. This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. PMID: 26517670
    2. dynamitin is involved in the regulation of Nav1.5 cell-surface density PMID: 25088759
    3. the determinants of p50/DM required for self-oligomerization of the protein and for interactions with other subunits of the dynactin complex PMID: 20463029
    4. Altered levels of Cep135 and p50 by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes. PMID: 14983524
    5. the Sec23p component of the COPII complex directly interacts with the dynactin complex through the carboxy-terminal cargo-binding domain of p150(Glued). PMID: 15580264
    6. DCTN2 is required in the earliest stages of peroxisome biogenesis. PMID: 15813749
    7. study does not support a major role for DCTN2 overexpression in carcinogenesis PMID: 16369996
    8. Data show how dynamitin's different structural domains contribute to its ability to self-associate, interact with dynactin and assemble into a complex with its close binding partner, p24. PMID: 18182012
    9. The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner. PMID: 18782227

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  • 亞細胞定位:
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    Dynactin subunit 2 family
  • 數據庫鏈接:

    HGNC: 2712

    OMIM: 607376

    KEGG: hsa:10540

    STRING: 9606.ENSP00000408910

    UniGene: Hs.289123



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