在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CPLX1 Antibody

  • 中文名稱:
    CPLX1兔多克隆抗體
  • 貨號:
    CSB-PA005893LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005893LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA005893LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CPLX1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    921-S antibody; complexin 1 antibody; Complexin I antibody; Complexin-1 antibody; CPLX1 antibody; CPLX1_HUMAN antibody; CPX I antibody; CPX-I antibody; CPX1 antibody; Synaphin 2 antibody; Synaphin-2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Complexin-1 protein (1-134AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CPLX1 Antibody (CSB-PA005893LA01HU),的標記方式是Non-conjugated。對于CPLX1 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA005893LB01HU CPLX1 Antibody, HRP conjugated ELISA
    FITC CSB-PA005893LC01HU CPLX1 Antibody, FITC conjugated
    Biotin CSB-PA005893LD01HU CPLX1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
  • 基因功能參考文獻:
    1. data define CPLX1 as a PD risk factor and provide functional insights into the role and regulation of blood SNCA levels. The new blood biomarkers of PARK4 in this Turkish family might become useful for PD prediction PMID: 28108469
    2. Homozygous CPLX1 variants were identified in three patients with severe infantile myoclonic epilepsy and ID. PMID: 28422131
    3. This study demonstrated that complexin-I influence cognitive function in early and late stages of Alzheimer's disease. PMID: 27866231
    4. Study showed for the first time that neuro-Behcet's disease and Behcet's disease patients are inclined to display the GG genotype of the CPLX1 rs936551 polymorphism and to exhibit increased CPLX1 expression levels PMID: 26577184
    5. Collectively these results demonstrate that CPX-1 is a secreted collagen-binding glycoprotein and provide a foundation for future studies investigating the function of CPX-1. PMID: 26603934
    6. Studies indicate the role of the small regulatory factor complexin in Ca(2+)-dependent vesicle fusion and exocytosis. PMID: 26245303
    7. Data support the the trans insertion model for complexin clamping. PMID: 25831964
    8. Together with synaptotagmin 1, complexin synchronizes and stimulates rapid fusion of accumulated docked vesicles in response to physiological Ca(2+) concentrations. PMID: 22705946
    9. The crystal structure of complexin bound to a prefusion SNAREpin mimetic shows that the accessory helix extends away from the SNAREpin in an 'open' conformation, binding another SNAREpin and inhibiting its assembly, to clamp fusion. PMID: 21785412
    10. The 'central helix' of complexin is anchored to one SNARE complex, while its 'accessory helix' extends away at ~45 degrees and bridges to a second complex, occupying the vacant v-SNARE binding site to inhibit fusion. PMID: 21785414
    11. description of what may represent a basic principle of the coupling mechanism in SNARE dependent exocytosis: a reversible clamping protein, complexin, that can freeze the SNAREpin, an assembled fusion-competent intermediate en route to fusion PMID: 16794037
    12. CX1 level increased progressively across development PMID: 18240322

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Perikaryon. Cell junction, synapse, presynapse.
  • 蛋白家族:
    Complexin/synaphin family
  • 組織特異性:
    Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
  • 數據庫鏈接:

    HGNC: 2309

    OMIM: 605032

    KEGG: hsa:10815

    STRING: 9606.ENSP00000305613

    UniGene: Hs.478930



主站蜘蛛池模板: 欧美人与性动交g欧美精器| 欧美特级婬片毛多的少妇| 午夜dy888国产精品影院| av免费网站在线观看| 中文字幕人成无码人妻| 久久人搡人人玩人妻精品首页| 又色又爽又黄的gif动态图| 永久免费无码网站在线观看个| a三级三级成人网站在线视频| 国产精品欧美一区二区三区不卡 | 在线视频夫妻内射| 欧美综合自拍亚洲图久青草| 久久国产精品_国产精品| 亚洲人成在线影院| 国产成人免费ā片在线观看老同学| 国产精品国产三级国产剧情| av片在线观看永久免费| 熟女人妻大叫粗大受不了| 亚洲精品第一国产综合境外资源| 男女裸交无遮挡啪啪激情试看| 国产综合色在线精品| 国产麻豆剧传媒精品av| 国产精品久久综合免费| 国产亚洲日韩av在线播放不卡 | k频道国产在线观看| 亚洲中文字幕无码永久| 狼友网精品视频在线观看| 18禁免费吃奶摸下激烈视频| 中文字幕精品亚洲无线码二区| 亚洲欧美一区二区三区| 国产欧美日韩亚洲精品专区| 内射老阿姨1区2区3区4区| 久久国产精品免费一区二区三区| 四虎永久在线精品免费观看视频| 日本japanese漂亮丰满| 大乳丰满人妻中文字幕日本| 久艹视频免费看| 在线永久无码不卡av| 中国女人做爰视频| 猫咪www免费人成网站无码| 亚洲国产成人精品无码区四虎|