在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CPLX1 Antibody

  • 中文名稱:
    CPLX1兔多克隆抗體
  • 貨號:
    CSB-PA005893GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    921-S antibody; complexin 1 antibody; Complexin I antibody; Complexin-1 antibody; CPLX1 antibody; CPLX1_HUMAN antibody; CPX I antibody; CPX-I antibody; CPX1 antibody; Synaphin 2 antibody; Synaphin-2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CPLX1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
  • 基因功能參考文獻:
    1. data define CPLX1 as a PD risk factor and provide functional insights into the role and regulation of blood SNCA levels. The new blood biomarkers of PARK4 in this Turkish family might become useful for PD prediction PMID: 28108469
    2. Homozygous CPLX1 variants were identified in three patients with severe infantile myoclonic epilepsy and ID. PMID: 28422131
    3. This study demonstrated that complexin-I influence cognitive function in early and late stages of Alzheimer's disease. PMID: 27866231
    4. Study showed for the first time that neuro-Behcet's disease and Behcet's disease patients are inclined to display the GG genotype of the CPLX1 rs936551 polymorphism and to exhibit increased CPLX1 expression levels PMID: 26577184
    5. Collectively these results demonstrate that CPX-1 is a secreted collagen-binding glycoprotein and provide a foundation for future studies investigating the function of CPX-1. PMID: 26603934
    6. Studies indicate the role of the small regulatory factor complexin in Ca(2+)-dependent vesicle fusion and exocytosis. PMID: 26245303
    7. Data support the the trans insertion model for complexin clamping. PMID: 25831964
    8. Together with synaptotagmin 1, complexin synchronizes and stimulates rapid fusion of accumulated docked vesicles in response to physiological Ca(2+) concentrations. PMID: 22705946
    9. The crystal structure of complexin bound to a prefusion SNAREpin mimetic shows that the accessory helix extends away from the SNAREpin in an 'open' conformation, binding another SNAREpin and inhibiting its assembly, to clamp fusion. PMID: 21785412
    10. The 'central helix' of complexin is anchored to one SNARE complex, while its 'accessory helix' extends away at ~45 degrees and bridges to a second complex, occupying the vacant v-SNARE binding site to inhibit fusion. PMID: 21785414
    11. description of what may represent a basic principle of the coupling mechanism in SNARE dependent exocytosis: a reversible clamping protein, complexin, that can freeze the SNAREpin, an assembled fusion-competent intermediate en route to fusion PMID: 16794037
    12. CX1 level increased progressively across development PMID: 18240322

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Perikaryon. Cell junction, synapse, presynapse.
  • 蛋白家族:
    Complexin/synaphin family
  • 組織特異性:
    Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
  • 數據庫鏈接:

    HGNC: 2309

    OMIM: 605032

    KEGG: hsa:10815

    STRING: 9606.ENSP00000305613

    UniGene: Hs.478930



主站蜘蛛池模板: 日韩乱码人妻无码中文字幕久久| 午夜电影网va内射| 忍着娇喘人妻被中出中文字幕| 亚洲综合日韩久久成人av| 欧洲丰满大乳人妻无码欧美| 无遮挡免费高清羞羞视频| 综合亚洲桃色第一影院| 免费无码毛片一区二区三区a片| 香港三级精品三级在线专区| 国产高清在线精品一区| 日韩精品无码一区二区三区| 亚洲最大的成人网站| 色综合视频一区中文字幕 | 国产精品久久久久aaaa| 国产高清在线精品一区| 青青草国产精品日韩欧美| 亚洲成a人v在线蜜臀| 东京热人妻丝袜av无码| 大胆欧美熟妇xx| 国产精品自在欧美一区| 亚洲精品一区国产欧美| 99九九99九九视频精品| 五月激情婷婷丁香综合基地| 99久久国产综合精品成人影院| 亚洲精品蜜夜内射| 丰满少妇被粗大的猛烈进出视频| 上司人妻互换hd无码| 内射女校花一区二区三区| 亚洲婷婷综合色高清在线| 精国产品一区二区三区a片| 亚洲精品无码成人网站| 亚洲国产精品成人影片久久| 亚洲综合激情另类专区| 青青草97国产精品免费观看| 精品三级av无码一区| 日本十八禁黄无遮禁视频免费| √最新版天堂资源网在线下载| 成人小说亚洲一区二区三区| 波多野结衣 黑人| 成人无码嫩草影院| 伊人久久大香线蕉av成人|