在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CPLX1 Antibody, FITC conjugated

  • 中文名稱:
    CPLX1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA005893LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CPLX1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    921-S antibody; complexin 1 antibody; Complexin I antibody; Complexin-1 antibody; CPLX1 antibody; CPLX1_HUMAN antibody; CPX I antibody; CPX-I antibody; CPX1 antibody; Synaphin 2 antibody; Synaphin-2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Complexin-1 protein (1-134AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
  • 基因功能參考文獻:
    1. data define CPLX1 as a PD risk factor and provide functional insights into the role and regulation of blood SNCA levels. The new blood biomarkers of PARK4 in this Turkish family might become useful for PD prediction PMID: 28108469
    2. Homozygous CPLX1 variants were identified in three patients with severe infantile myoclonic epilepsy and ID. PMID: 28422131
    3. This study demonstrated that complexin-I influence cognitive function in early and late stages of Alzheimer's disease. PMID: 27866231
    4. Study showed for the first time that neuro-Behcet's disease and Behcet's disease patients are inclined to display the GG genotype of the CPLX1 rs936551 polymorphism and to exhibit increased CPLX1 expression levels PMID: 26577184
    5. Collectively these results demonstrate that CPX-1 is a secreted collagen-binding glycoprotein and provide a foundation for future studies investigating the function of CPX-1. PMID: 26603934
    6. Studies indicate the role of the small regulatory factor complexin in Ca(2+)-dependent vesicle fusion and exocytosis. PMID: 26245303
    7. Data support the the trans insertion model for complexin clamping. PMID: 25831964
    8. Together with synaptotagmin 1, complexin synchronizes and stimulates rapid fusion of accumulated docked vesicles in response to physiological Ca(2+) concentrations. PMID: 22705946
    9. The crystal structure of complexin bound to a prefusion SNAREpin mimetic shows that the accessory helix extends away from the SNAREpin in an 'open' conformation, binding another SNAREpin and inhibiting its assembly, to clamp fusion. PMID: 21785412
    10. The 'central helix' of complexin is anchored to one SNARE complex, while its 'accessory helix' extends away at ~45 degrees and bridges to a second complex, occupying the vacant v-SNARE binding site to inhibit fusion. PMID: 21785414
    11. description of what may represent a basic principle of the coupling mechanism in SNARE dependent exocytosis: a reversible clamping protein, complexin, that can freeze the SNAREpin, an assembled fusion-competent intermediate en route to fusion PMID: 16794037
    12. CX1 level increased progressively across development PMID: 18240322

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Perikaryon. Cell junction, synapse, presynapse.
  • 蛋白家族:
    Complexin/synaphin family
  • 組織特異性:
    Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
  • 數據庫鏈接:

    HGNC: 2309

    OMIM: 605032

    KEGG: hsa:10815

    STRING: 9606.ENSP00000305613

    UniGene: Hs.478930



主站蜘蛛池模板: 风韵人妻丰满熟妇老熟女| 性史性农村dvd毛片| 欧美无遮挡很黄裸交视频| 久久精品国产精品亚洲艾草网 | 激情综合色五月丁香六月欧美| 色偷偷亚洲男人本色| 女人裸体做爰免费视频| 丰满岳乱妇在线观看中字| 免费看成人午夜福利专区| 18禁黄网站禁片免费观看女女| 日日噜狠狠噜天天噜av| 精品免费国产一区二区三区四区| 综合天堂av久久久久久久| 国产99久久亚洲综合精品西瓜tv| 欧美日韩精品成人网站二区| 久久99精品网久久| 日韩精品一区二区三区视频| 亚洲鲁丝片一区二区三区| 亚洲色无码专区在线播放| 国产97人妻人人做人碰人人爽| 朝鲜女子内射杂交bbw| 日韩一欧美内射在线观看| 久久久久久a亚洲欧洲av| 制服视频在线一区二区| 国产成人av在线免播放观看| 一本大道东京热无码一区| 人妻无码中文专区久久app| 蜜桃视频韩日免费播放| 国产真实乱对白精彩久久| 亚洲 中文字幕 日韩 无码| 亚洲国产天堂久久综合| 辽宁熟女高潮狂叫视频| 8x国产精品视频| 成人欧美一区二区三区的电影| 亚洲国产精彩中文乱码av| 精品av中文字幕在线毛片| 好紧好湿好黄的视频| 成 年 人 黄 色 大 片大 全| 日日摸天天碰中文字幕你懂的| 亚洲精品中文字幕久久久久下载| 亲子乱子伦xxxx视频|