在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CLCNKA Antibody

CLCNKA Antibody

  • 中文名稱：
    CLCNKA兔多克隆抗體
  • 貨號(hào)：
    CSB-PA005487GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CLCNKA
  • 別名：
    CLCNKAChloride channel protein ClC-Ka antibody; Chloride channel Ka antibody; ClC-K1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CLCNKA
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
  • 基因功能參考文獻(xiàn)：
    1. Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk. PMID: 25919862
    2. R8W and G47R, two naturally occurring barttin mutations identified in patients with Bartter syndrome type IV, reduce barttin palmitoylation and CLC-K/barttin channel activity. PMID: 26013830
    3. HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka/barttin and CLC-Kb/barttin channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved PMID: 24863058
    4. following variables were significantly associated with an estimated glomerular filtration rate: age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype PMID: 23850580
    5. The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis. PMID: 21248228
    6. Identify a protein region that is involved in calcium binding and that is likely undergoing conformational changes underlying the complex gating of CLC-K channels. PMID: 20805576
    7. Combined impairment of ClC-Ka and ClC-Kb results in phenotype that mimics neonatal Barrter's syndrome with deafness PMID: 15044642
    8. Barttin modulates trafficking and function of ClC-K1 and ClC-Kb channels PMID: 16849430
    9. CLCNKA genetic variants may have roles in salt-sensitive hypertension PMID: 17510212
    10. The structure of the cytoplasmic domain of CLCNKA reveals a conserved interaction interface. PMID: 17562318
    11. Disruption of the gene encoding Barttin, BSND, results in a 'double knockout' of the functions of both ClCKA and ClCKB, manifesting as Bartter syndrome type IV with sensorineural deafness and an especially severe salt-losing phenotype. PMID: 18094726
    12. ClC-Ka and ClC-Kb differ in how conformational changes are translated to the extracellular domain, despite the fact that the cytoplasmic domains share the same quaternary structure PMID: 18648499

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Bartter syndrome 4B, neonatal, with sensorineural deafness (BARTS4B)
  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, CLCNKA subfamily
  • 組織特異性：
    Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2026

    OMIM: 602024

    KEGG: hsa:1187

    STRING: 9606.ENSP00000332771

    UniGene: Hs.591533



主站蜘蛛池模板： 乌克兰少妇性做爰| 亚洲日韩色欲色欲com| 久久久精品人妻一区二区三区四| 51精品国产人成在线观看| 熟女俱乐部五十路六十路av| 五月婷婷之综合缴情| 久久亚洲色www成人不卡| 日本欧美一区二区三区乱码| 国产精品呻吟久久人妻无吗| 人妻精品制服丝袜久久久| 亚洲欧洲综合有码无码| 国产熟妇乱xxxxx大屁股网| 日韩中文字幕在线一区二区三区| 亚洲成av人片不卡无码久久| 亚洲精品国产自在现线最新| av永久天堂一区二区三区| 中日韩高清无专码区2021| 宅男宅女精品国产av天堂| 亚洲a∨无码国产精品久久网| 精品无码国产一区二区三区麻豆| 又黄又爽又色视频免费| 色先锋影音岛国av资源| 欧美日韩亚洲中文字幕一区二区三区 | 无码一区二区三区老色鬼| 久久只精品99品免费久23| 丁香五月欧美成人| 国产精品自在拍在线播放| 99999久久久久久亚洲| 制服丝袜另类专区制服| 99这里只有精品| 四虎永久在线精品免费观看视频| 中文字幕av无码一二三区电影| 强开小婷嫩苞又嫩又紧视频| 又色又爽又黄的gif动态图| 青青草国产精品人人爱| 99精品欧美一区二区三区| 午夜时刻免费入口| av天堂久久精品影音先锋| 激情综合一区二区三区| 久久久免费精品re6| 2020年无码国产精品高清免费|