在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CLCNKA Antibody

  • 中文名稱:
    CLCNKA兔多克隆抗體
  • 貨號:
    CSB-PA831274
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HuvEc cells, using CLCNKA antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CLCNKA Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CLCNKA
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from C-terminal of Human CLCNKA.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
  • 基因功能參考文獻:
    1. Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk. PMID: 25919862
    2. R8W and G47R, two naturally occurring barttin mutations identified in patients with Bartter syndrome type IV, reduce barttin palmitoylation and CLC-K/barttin channel activity. PMID: 26013830
    3. HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka/barttin and CLC-Kb/barttin channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved PMID: 24863058
    4. following variables were significantly associated with an estimated glomerular filtration rate: age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype PMID: 23850580
    5. The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis. PMID: 21248228
    6. Identify a protein region that is involved in calcium binding and that is likely undergoing conformational changes underlying the complex gating of CLC-K channels. PMID: 20805576
    7. Combined impairment of ClC-Ka and ClC-Kb results in phenotype that mimics neonatal Barrter's syndrome with deafness PMID: 15044642
    8. Barttin modulates trafficking and function of ClC-K1 and ClC-Kb channels PMID: 16849430
    9. CLCNKA genetic variants may have roles in salt-sensitive hypertension PMID: 17510212
    10. The structure of the cytoplasmic domain of CLCNKA reveals a conserved interaction interface. PMID: 17562318
    11. Disruption of the gene encoding Barttin, BSND, results in a 'double knockout' of the functions of both ClCKA and ClCKB, manifesting as Bartter syndrome type IV with sensorineural deafness and an especially severe salt-losing phenotype. PMID: 18094726
    12. ClC-Ka and ClC-Kb differ in how conformational changes are translated to the extracellular domain, despite the fact that the cytoplasmic domains share the same quaternary structure PMID: 18648499

    顯示更多

    收起更多

  • 相關疾病:
    Bartter syndrome 4B, neonatal, with sensorineural deafness (BARTS4B)
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Chloride channel (TC 2.A.49) family, CLCNKA subfamily
  • 組織特異性:
    Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.
  • 數據庫鏈接:

    HGNC: 2026

    OMIM: 602024

    KEGG: hsa:1187

    STRING: 9606.ENSP00000332771

    UniGene: Hs.591533



主站蜘蛛池模板: 成人无码av网站在线观看| 韩国三级hd中文字幕| 免费看美女被靠到爽的视频| 四虎永久在线精品免费视频观看| 日韩国产网曝欧美第一页| 国产精品va在线播放| 国产小呦泬泬99精品| 中文人妻无码一区二区三区信息| 久久久喷潮一区二区三区| 扒开双腿猛进入喷水高潮视频 | 国产桃色无码视频在线观看 | 亚洲愉拍自拍另类天堂| 男受被做哭激烈娇喘gv视频| 国产欧美综合一区二区三区| 免费高清av一区二区三区| 久久理论片午夜琪琪电影网| 裸身美女无遮挡永久免费视频| 解开人妻的裙子猛烈进入| 久草热8精品视频在线观看| 肉体裸交137日本大胆摄影 | 性夜影院午夜看片| 久欠精品国国产99国产精2021| 亚洲人成欧美中文字幕| 非洲人与性动交ccoo| 亚欧欧美人成视频在线| 日韩午夜理论片 中文字幕| 亚洲一区二区三区偷拍女厕| 少妇愉情理伦片高潮日本| 中文字幕+乱码+中文乱码www| 亚洲日韩欧美在线成人| 午夜久久久久久禁播电影| 99国产精品久久久蜜芽| 国产av福利久久| 日本成本人片免费网站 | 亚洲日韩精品一区二区三区无码| 狠狠色狠狠色狠狠五月| 最新国产在线拍揄自揄视频| 亚洲日韩精品欧美一区二区一| 亚洲欧美日韩中文加勒比| 激情射精爽到偷偷c视频无码| 国产免费无遮挡吸乳视频|