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CLCNKA Antibody

  • 中文名稱:
    CLCNKA兔多克隆抗體
  • 貨號:
    CSB-PA001688
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HuvEc cells using CLC-KA Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CLCNKA
  • 別名:
    CLCNKAChloride channel protein ClC-Ka antibody; Chloride channel Ka antibody; ClC-K1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human CLC-KA.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
  • 基因功能參考文獻:
    1. Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk. PMID: 25919862
    2. R8W and G47R, two naturally occurring barttin mutations identified in patients with Bartter syndrome type IV, reduce barttin palmitoylation and CLC-K/barttin channel activity. PMID: 26013830
    3. HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka/barttin and CLC-Kb/barttin channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved PMID: 24863058
    4. following variables were significantly associated with an estimated glomerular filtration rate: age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype PMID: 23850580
    5. The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis. PMID: 21248228
    6. Identify a protein region that is involved in calcium binding and that is likely undergoing conformational changes underlying the complex gating of CLC-K channels. PMID: 20805576
    7. Combined impairment of ClC-Ka and ClC-Kb results in phenotype that mimics neonatal Barrter's syndrome with deafness PMID: 15044642
    8. Barttin modulates trafficking and function of ClC-K1 and ClC-Kb channels PMID: 16849430
    9. CLCNKA genetic variants may have roles in salt-sensitive hypertension PMID: 17510212
    10. The structure of the cytoplasmic domain of CLCNKA reveals a conserved interaction interface. PMID: 17562318
    11. Disruption of the gene encoding Barttin, BSND, results in a 'double knockout' of the functions of both ClCKA and ClCKB, manifesting as Bartter syndrome type IV with sensorineural deafness and an especially severe salt-losing phenotype. PMID: 18094726
    12. ClC-Ka and ClC-Kb differ in how conformational changes are translated to the extracellular domain, despite the fact that the cytoplasmic domains share the same quaternary structure PMID: 18648499

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  • 相關疾病:
    Bartter syndrome 4B, neonatal, with sensorineural deafness (BARTS4B)
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Chloride channel (TC 2.A.49) family, CLCNKA subfamily
  • 組織特異性:
    Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.
  • 數據庫鏈接:

    HGNC: 2026

    OMIM: 602024

    KEGG: hsa:1187

    STRING: 9606.ENSP00000332771

    UniGene: Hs.591533



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