在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CLCNKA Antibody

CLCNKA Antibody

  • 中文名稱：
    CLCNKA兔多克隆抗體
  • 貨號：
    CSB-PA001688
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HuvEc cells using CLC-KA Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CLCNKA
  • 別名：
    CLCNKAChloride channel protein ClC-Ka antibody; Chloride channel Ka antibody; ClC-K1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human CLC-KA.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
  • 基因功能參考文獻：
    1. Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk. PMID: 25919862
    2. R8W and G47R, two naturally occurring barttin mutations identified in patients with Bartter syndrome type IV, reduce barttin palmitoylation and CLC-K/barttin channel activity. PMID: 26013830
    3. HEK293 cells the potentiating effect of niflumic acid (NFA) on CLC-Ka/barttin and CLC-Kb/barttin channels seems to be absent while the blocking efficacy of niflumic acid and benzofuran derivatives observed in oocytes is preserved PMID: 24863058
    4. following variables were significantly associated with an estimated glomerular filtration rate: age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype PMID: 23850580
    5. The variant CLCNKA risk allele, telegraphed by linked variants in the adjacent HSPB7 gene, uncovers a previously overlooked genetic mechanism affecting the cardio-renal axis. PMID: 21248228
    6. Identify a protein region that is involved in calcium binding and that is likely undergoing conformational changes underlying the complex gating of CLC-K channels. PMID: 20805576
    7. Combined impairment of ClC-Ka and ClC-Kb results in phenotype that mimics neonatal Barrter's syndrome with deafness PMID: 15044642
    8. Barttin modulates trafficking and function of ClC-K1 and ClC-Kb channels PMID: 16849430
    9. CLCNKA genetic variants may have roles in salt-sensitive hypertension PMID: 17510212
    10. The structure of the cytoplasmic domain of CLCNKA reveals a conserved interaction interface. PMID: 17562318
    11. Disruption of the gene encoding Barttin, BSND, results in a 'double knockout' of the functions of both ClCKA and ClCKB, manifesting as Bartter syndrome type IV with sensorineural deafness and an especially severe salt-losing phenotype. PMID: 18094726
    12. ClC-Ka and ClC-Kb differ in how conformational changes are translated to the extracellular domain, despite the fact that the cytoplasmic domains share the same quaternary structure PMID: 18648499

    顯示更多

    收起更多

  • 相關疾病：
    Bartter syndrome 4B, neonatal, with sensorineural deafness (BARTS4B)
  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, CLCNKA subfamily
  • 組織特異性：
    Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins.
  • 數據庫鏈接：

    HGNC: 2026

    OMIM: 602024

    KEGG: hsa:1187

    STRING: 9606.ENSP00000332771

    UniGene: Hs.591533



主站蜘蛛池模板： 精品 在线 视频 亚洲| 久久一本久综合久久爱| 国产欧美日韩综合在线成| 717影院理论午夜伦八戒| a国产一区二区免费入口| 寂寞少妇做spa按摩无码| 久久亚洲精品无码爱剪辑| 在线精品亚洲第一区焦香| 久久婷婷香蕉热狠狠综合| 国偷自产一区二区免费视频| 欧美激情一区二区成人| 成人免费午夜无码视频| 蜜臀av无码精品人妻色欲| 成人精品视频一区二区三区 | 欧美熟妇另类久久久久久不卡| 国产福利精品一区二区| 国产av精品一区二区三区小说| 正在播放国产乱子伦最新视频| 中文字幕丰满乱子伦无码专区| 亚洲欧洲日产国码在线| 被窝影院午夜无码国产| 久久精品国产一区二区电影| 男人扒女人添高潮视频| 亚洲高清无在码在线电影| 正在播放熟妇群老熟妇456 | 少妇被躁爽到高潮无码久久| 国产无套内射又大又猛又粗又爽| 一区二区三区鲁丝不卡麻豆| 成人午夜亚洲精品无码区| 天天综合网网欲色| 国产精品激情欧美可乐视频| 精品一区二区成人精品| 天天天天躁天天爱天天碰2018| 色综合色综合久久综合频道88| 欧美婷婷六月丁香综合| 亚洲日本成本人观看| 国产欧美综合一区二区三区| 成人av在线一区二区三区| 国产无遮挡又黄又爽网站| 成人免费看片又大又黄| 在线播放十八禁视频无遮挡 |