在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CHMP1A Antibody

CHMP1A Antibody

  • 中文名稱：
    CHMP1A兔多克隆抗體
  • 貨號：
    CSB-PA005358GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Charged multivesicular body protein 1a antibody; CHM1A_HUMAN antibody; CHMP1a antibody; Chromatin modifying protein 1a antibody; Chromatin-modifying protein 1a antibody; hVps46 1 antibody; hVps46-1 antibody; KIAA0047 antibody; Metalloprotease 1 antibody; PCOLN3 antibody; Procollagen (type III) N endopeptidase antibody; PRSM1 antibody; Vacuolar protein sorting 46 1 antibody; Vacuolar protein sorting-associated protein 46-1 antibody; Vps46 1 antibody; Vps46-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CHMP1A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
  • 基因功能參考文獻：
    1. Letter: rs6860 polymorphism of the CHMP1A gene, is associated with fibromyalgia susceptibility in southern Spanish women. PMID: 29247346
    2. we identified Ser(179) and Ser(182) located in the C-terminal region of the CHMP1A as major phosphorylation sites that cause a mobility shift. PMID: 23748770
    3. Study reports the discovery of a chimeric RNA between ZC3HAV1L and CHMP1A in human, located on chromosome 7 and 16, respectively. The fusion occurs at an exon-exon boundary, and was detected both computationally and experimentally from different cells or tissue types. PMID: 23273016
    4. Our results suggest that CHMP1A serves as a critical link between cytoplasmic signals and BMI1-mediated chromatin modifications that regulate proliferation of central nervous system progenitor cells. PMID: 23023333
    5. our results demonstrate that Chmp1A functions as a tumor suppressor gene in renal cells PMID: 22261332
    6. Chmp1A regulates tumor growth through ATM sugnaling and that neclear locaization of Chmp1A is reqired for the growth inhibition and ATM activation. PMID: 21705858
    7. UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common interactions with CHMP1A and CHMP1B but a distinct selectivity of AMSH for CHMP3/VPS24, a core subunit of the ESCRT-III complex, and UBPY for CHMP7. PMID: 17711858
    8. Chmp1A is a novel tumor suppressor, especially in pancreas and that Chmp1A regulates tumor growth potentially through p53 signaling pathway. PMID: 18787405
    9. Both Vps4A and CHMP1A localized in the vicinity of viral cytoplasmic assembly compartments, sites of viral maturation that develop in Cytomegalovirus-infected cells. Thus, ESCRT machinery is involved in the final steps of HCMV replication. PMID: 19640981

    顯示更多

    收起更多

  • 相關疾病：
    Pontocerebellar hypoplasia 8 (PCH8)
  • 亞細胞定位：
    Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
  • 蛋白家族：
    SNF7 family
  • 組織特異性：
    Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63.
  • 數據庫鏈接：

    HGNC: 8740

    OMIM: 164010

    KEGG: hsa:5119

    STRING: 9606.ENSP00000380998

    UniGene: Hs.589427



主站蜘蛛池模板： 成人黄网站高清免费视频| 最新欧美精品一区二区三区| 亚洲欧洲美洲在线观看| 国产精品久久| 大又大粗又爽又黄少妇毛片| 内射毛片内射国产夫妻| 内射巨臀欧美在线视频| 女人扒下裤让男人桶到爽| 国内精品久久久久久久电影视 | 性色av无码中文av有码vr| 真实国产精品视频400部| а天堂中文最新版在线| 波多野结衣人妻| 国产手机在线精品| 久久青青草原国产免费播放| 92午夜少妇极品福利无码电影| 大伊香蕉精品一区二区| 无码人妻丰满熟妇区96| 超碰人人超碰人人| 国精品人妻无码一区二区三区d3 | 亚洲 欧美 国产 综合免费| 国产亚洲欧美精品永久| 男女做爰真人视频直播| 99久久国语露脸精品国产| 婷婷丁香五月六月综合激情啪| 亚洲日韩国产精品无码av| 无码播放一区二区三区| 蜜桃av抽搐高潮一区二区| 青青草国产午夜精品| 久久三级中文欧大战字幕| 亚洲熟妇无码av不卡在线| 久久综合给合综合久久| 色狠狠一区二区三区香蕉| 国产漂亮白嫩美女在线观看| 国产成人av在线影院无毒| 丰满的少妇xxxxx青青青| 97视频在线观看播放| 奶真大水真多小荡货av| 国产真人作爱免费视频道歉| 免费无码又爽又高潮视频| 久久久久无码中|