在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CHMP1A Antibody, Biotin conjugated

CHMP1A Antibody, Biotin conjugated

  • 中文名稱：
    CHMP1A兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA881032LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CHMP1A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Charged multivesicular body protein 1a antibody; CHM1A_HUMAN antibody; CHMP1a antibody; Chromatin modifying protein 1a antibody; Chromatin-modifying protein 1a antibody; hVps46 1 antibody; hVps46-1 antibody; KIAA0047 antibody; Metalloprotease 1 antibody; PCOLN3 antibody; Procollagen (type III) N endopeptidase antibody; PRSM1 antibody; Vacuolar protein sorting 46 1 antibody; Vacuolar protein sorting-associated protein 46-1 antibody; Vps46 1 antibody; Vps46-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Charged multivesicular body protein 1a protein (1-196AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
  • 基因功能參考文獻：
    1. Letter: rs6860 polymorphism of the CHMP1A gene, is associated with fibromyalgia susceptibility in southern Spanish women. PMID: 29247346
    2. we identified Ser(179) and Ser(182) located in the C-terminal region of the CHMP1A as major phosphorylation sites that cause a mobility shift. PMID: 23748770
    3. Study reports the discovery of a chimeric RNA between ZC3HAV1L and CHMP1A in human, located on chromosome 7 and 16, respectively. The fusion occurs at an exon-exon boundary, and was detected both computationally and experimentally from different cells or tissue types. PMID: 23273016
    4. Our results suggest that CHMP1A serves as a critical link between cytoplasmic signals and BMI1-mediated chromatin modifications that regulate proliferation of central nervous system progenitor cells. PMID: 23023333
    5. our results demonstrate that Chmp1A functions as a tumor suppressor gene in renal cells PMID: 22261332
    6. Chmp1A regulates tumor growth through ATM sugnaling and that neclear locaization of Chmp1A is reqired for the growth inhibition and ATM activation. PMID: 21705858
    7. UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common interactions with CHMP1A and CHMP1B but a distinct selectivity of AMSH for CHMP3/VPS24, a core subunit of the ESCRT-III complex, and UBPY for CHMP7. PMID: 17711858
    8. Chmp1A is a novel tumor suppressor, especially in pancreas and that Chmp1A regulates tumor growth potentially through p53 signaling pathway. PMID: 18787405
    9. Both Vps4A and CHMP1A localized in the vicinity of viral cytoplasmic assembly compartments, sites of viral maturation that develop in Cytomegalovirus-infected cells. Thus, ESCRT machinery is involved in the final steps of HCMV replication. PMID: 19640981

    顯示更多

    收起更多

  • 相關疾病：
    Pontocerebellar hypoplasia 8 (PCH8)
  • 亞細胞定位：
    Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
  • 蛋白家族：
    SNF7 family
  • 組織特異性：
    Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63.
  • 數據庫鏈接：

    HGNC: 8740

    OMIM: 164010

    KEGG: hsa:5119

    STRING: 9606.ENSP00000380998

    UniGene: Hs.589427



主站蜘蛛池模板： 色五月丁香五月综合五月| 成人午夜亚洲精品无码区| 国产性生交xxxxx无码| 蜜桃视频在线观看免费视频网站www | 亚洲小说图区综合在线| 欧美老妇牲交videos| 亚洲人成人伊人成综合网无码| 国产精品亚洲专区无码老司国| 衣服被扒开强摸双乳18禁网站 | 无码精品国产dvd在线观看9久| 欧美三級片黃色三級片黃色| 天天鲁在视频在线观看| 亚洲一区二区三区四区| 国产成人久久精品77777综合| 日本熟妇色xxxxx日本免费看| 中文在线а天堂| 亚洲成a人v电影在线观看| 国产国拍精品av在线观看按摩| 国产精品成人va在线观看| 国产无遮挡裸体免费视频| 天天澡天天揉揉av无码| 久久久精品中文字幕乱码18| 久久久久成人片免费观看蜜芽| 国产乱子夫妻xx黑人xyx真爽| 黄页网站视频| 成人无码嫩草影院| 在线a毛片免费视频观看| 天天综合网天天综合色| 国产精品久久久久久无码| 忘忧草日本在线www| 亚洲亚洲人成综合丝袜图片| 国产区精品福利在线社区| 亚洲日本韩国| 最新永久无码av网址亚洲| 久久视热这里只有精品| 激情综合婷婷丁香五月| 国产激情久久久久影院老熟女免费| 亚洲2021av天堂手机版| 欧美成人高清视频a在线看| 免费欧洲美女牲交视频| 欧洲多毛裸体xxxxx|