在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CHMP1A Antibody

CHMP1A Antibody

  • 中文名稱：
    CHMP1A兔多克隆抗體
  • 貨號：
    CSB-PA881032LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: 293T whole cell lysate
      All lanes: CHMP1A antibody at 4.2µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 22, 8 kDa
      Observed band size: 22 kDa
    • IHC image of CSB-PA881032LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA881032LA01HU diluted at 1:200 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA881032LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CHMP1A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Charged multivesicular body protein 1a antibody; CHM1A_HUMAN antibody; CHMP1a antibody; Chromatin modifying protein 1a antibody; Chromatin-modifying protein 1a antibody; hVps46 1 antibody; hVps46-1 antibody; KIAA0047 antibody; Metalloprotease 1 antibody; PCOLN3 antibody; Procollagen (type III) N endopeptidase antibody; PRSM1 antibody; Vacuolar protein sorting 46 1 antibody; Vacuolar protein sorting-associated protein 46-1 antibody; Vps46 1 antibody; Vps46-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Charged multivesicular body protein 1a protein (1-196AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CHMP1A Antibody (CSB-PA881032LA01HU)，的標記方式是Non-conjugated。對于CHMP1A Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA881032LB01HU CHMP1A Antibody, HRP conjugated ELISA
    FITC CSB-PA881032LC01HU CHMP1A Antibody, FITC conjugated
    Biotin CSB-PA881032LD01HU CHMP1A Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.
  • 基因功能參考文獻：
    1. Letter: rs6860 polymorphism of the CHMP1A gene, is associated with fibromyalgia susceptibility in southern Spanish women. PMID: 29247346
    2. we identified Ser(179) and Ser(182) located in the C-terminal region of the CHMP1A as major phosphorylation sites that cause a mobility shift. PMID: 23748770
    3. Study reports the discovery of a chimeric RNA between ZC3HAV1L and CHMP1A in human, located on chromosome 7 and 16, respectively. The fusion occurs at an exon-exon boundary, and was detected both computationally and experimentally from different cells or tissue types. PMID: 23273016
    4. Our results suggest that CHMP1A serves as a critical link between cytoplasmic signals and BMI1-mediated chromatin modifications that regulate proliferation of central nervous system progenitor cells. PMID: 23023333
    5. our results demonstrate that Chmp1A functions as a tumor suppressor gene in renal cells PMID: 22261332
    6. Chmp1A regulates tumor growth through ATM sugnaling and that neclear locaization of Chmp1A is reqired for the growth inhibition and ATM activation. PMID: 21705858
    7. UBPY MIT domain and another ubiquitin isopeptidase, AMSH, reveals common interactions with CHMP1A and CHMP1B but a distinct selectivity of AMSH for CHMP3/VPS24, a core subunit of the ESCRT-III complex, and UBPY for CHMP7. PMID: 17711858
    8. Chmp1A is a novel tumor suppressor, especially in pancreas and that Chmp1A regulates tumor growth potentially through p53 signaling pathway. PMID: 18787405
    9. Both Vps4A and CHMP1A localized in the vicinity of viral cytoplasmic assembly compartments, sites of viral maturation that develop in Cytomegalovirus-infected cells. Thus, ESCRT machinery is involved in the final steps of HCMV replication. PMID: 19640981

    顯示更多

    收起更多

  • 相關疾病：
    Pontocerebellar hypoplasia 8 (PCH8)
  • 亞細胞定位：
    Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
  • 蛋白家族：
    SNF7 family
  • 組織特異性：
    Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63.
  • 數據庫鏈接：

    HGNC: 8740

    OMIM: 164010

    KEGG: hsa:5119

    STRING: 9606.ENSP00000380998

    UniGene: Hs.589427



主站蜘蛛池模板： 国产成人剧情av麻豆果冻| 成人天堂婷婷青青视频在线观看| 免费国产又色又爽又黄的网站 | 国产精品.xx视频.xxtv| 午夜免费视频| 97色伦综合在线欧美视频| 国产亚洲综合久久系列| 狠狠躁夜夜躁人人爽天天天天| 亚洲成在人线在线播放无码| 国产成人8x人网站视频| 亚洲综合无码av一区二区三区| av无码免费岛国动作片不卡| 亚洲欧洲自拍拍偷午夜色| 亚洲欧洲日产国码在线| 人人玩人人添人人澡欧美| а√天堂8资源在线官网| 97精品久久久久中文字幕| 99久久久无码国产精品秋霞网| 扒开双腿猛进入喷水高潮叫声| 亚洲欧美国产免费综合视频| 国产免费mv大片人人电影播放器| 精品无码av无码专区| 精品国产亚洲午夜精品av| 亚洲精品一区久久久久久| 国产色婷婷五月精品综合在线| 18禁无遮挡无码网站免费| 成熟女人特级毛片www免费| 久久精品人妻无码专区| 亚洲 欧美 国产 日韩 精品| 韩国精品无码少妇在线观看| 少妇被黑人4p到惨叫欧美人| 欧洲无码一区二区三区在线观看| 美女露全乳无遮掩视频| 精品国产乱码久久久久乱码| 欧美另类精品xxxx人妖| 免费看成人aa片无码视频吃奶| 亚洲a∨无码一区二区| 国产福利萌白酱精品tv一区| 伊人久久精品无码麻豆一区| 人妻无码视频一区二区三区| 天天爽天天摸天天碰|