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  4. CD1E Antibody

CD1E Antibody

  • 中文名稱：
    CD1E兔多克隆抗體
  • 貨號：
    CSB-PA004893LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA004893LA01HU diluted at 1:300 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CD1E Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD_antigen=CD1e antibody; CD1A antibody; CD1e antibody; CD1e antigen antibody; CD1E antigen; e polypeptide antibody; CD1e molecule antibody; CD1E_HUMAN antibody; Differentiation antigen CD1-alpha-3 antibody; hCD1e antibody; Leukocyte differentiation antigen antibody; R2 antibody; R2G1 antibody; sCD1e antibody; soluble antibody; T-cell surface glycoprotein CD1e antibody; T-cell surface glycoprotein CD1e; membrane-associated antibody; T-cell surface glycoprotein CD1e; soluble antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human T-cell surface glycoprotein CD1e, membrane-associated protein (198-294AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CD1E Antibody (CSB-PA004893LA01HU)，的標記方式是Non-conjugated。對于CD1E Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA004893LB01HU CD1E Antibody, HRP conjugated ELISA
    FITC CSB-PA004893LC01HU CD1E Antibody, FITC conjugated
    Biotin CSB-PA004893LD01HU CD1E Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.
  • 基因功能參考文獻：
    1. There was no association between polymorphisms of CD1E genes and the susceptibilities to Guillain-Barre syndrome. PMID: 27653862
    2. The interaction of LAPTM5 with CD1e and their colocalization in antigen processing compartments both suggest that LAPTM5 might influence the role of CD1e in the presentation of lipid antigens. PMID: 22880058
    3. in the late endosomes/lysosomes of dendritic cells, the acid pH promotes the binding of lipid antigens to CD1e through increased hydrophobic and ionic interactions PMID: 21481186
    4. allelic variation in CD1E does not play a major role in determining multifocal motor neuropathy susceptibility. PMID: 22003931
    5. CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. PMID: 21844346
    6. These data support that CD1e could have evolved to mediate lipid-exchange/editing processes. PMID: 21788486
    7. substitutions lead to amino acid changes at position 73 and 77 of the alpha1 domain in the former and at position 30 of the alpha2 domain in the latter suggesting that the CD1E gene is much more polymorphic than previously assumed. PMID: 12144626
    8. cellular and biochemical properties of the human and simian CD1e molecules are similar, suggesting that the particular intracellular distribution of CD1e is important for its physiological and/or immunological function PMID: 12671734
    9. required for processing of the mycobcterial antigens hexamannosylated phosphatidyl-myo-inositols(PIM6); propose that, through this form of glycolipid editing, CD1e helps expand the repertoire of glycolipidic T cell antigens to optimize immune response PMID: 16311334
    10. Data show that ubiquitination of CD1e appears to trigger its exit from Golgi compartments and its transport to endosomes. PMID: 18208508
    11. A polymorphism related to the capacity of the CD1E molecule to participate in the immune response to complex glycolipids is discovered in individuals who might display a CD1e-altered immune response to complex glycolipid antigens. PMID: 18325888
    12. CD1e propeptide is conserved during evolution, suggesting that it may also optimize the generation of CD1e molecules in other species. PMID: 19196239

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  • 亞細胞定位：
    [T-cell surface glycoprotein CD1e, membrane-associated]: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.; [T-cell surface glycoprotein CD1e, soluble]: Lysosome lumen.
  • 組織特異性：
    Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.
  • 數據庫鏈接：

    HGNC: 1638

    OMIM: 188411

    KEGG: hsa:913

    STRING: 9606.ENSP00000357149

    UniGene: Hs.249217



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