在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CCS Antibody

  • 中文名稱:
    CCS兔多克隆抗體
  • 貨號:
    CSB-PA004854LA01HU
  • 規格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA004854LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CCS Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CCS
  • 別名:
    CCS antibody; CCS_HUMAN antibody; Copper chaperone for superoxide dismutase antibody; MGC138260 antibody; SOD 4 antibody; SOD4 antibody; Superoxide dismutase copper chaperone antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Copper chaperone for superoxide dismutase protein (145-274AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CCS Antibody (CSB-PA004854LA01HU),的標記方式是Non-conjugated。對于CCS Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA004854LB01HU CCS Antibody, HRP conjugated ELISA
    FITC CSB-PA004854LC01HU CCS Antibody, FITC conjugated
    Biotin CSB-PA004854LD01HU CCS Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Delivers copper to copper zinc superoxide dismutase (SOD1).
  • 基因功能參考文獻:
    1. In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (i.e. CCS) and cytochrome c oxidase in mitochondria (i.e. Cox17). [review] PMID: 26745464
    2. Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro PMID: 25673218
    3. Coexpression of hCCS in the presence of copper restores the correct maturation of the SOD1 mutants and prevents the formation of the unstructured species, confirming that hCCS also acts as a molecular chaperone. PMID: 25429517
    4. CCS mRNA and protein levels in the serum are not correlated with inflammatory processes. PMID: 24855044
    5. CTR1 silencing increased the protein levels of copper chaperone ATOX1 and copper chaperone for superoxide dismutase 1 (CCS-1), but decreased copper chaperone for cytochrome c oxidase (COX17). PMID: 24343031
    6. CCS1 serves as a specialized import receptor in mitochondria that facilitates the import and folding of SOD1 and CCS1. PMID: 24026195
    7. CCS-dependent copper acquisition and distribution largely occur at membrane interfaces and that this emerging role of the bilayer may reflect a general mechanistic aspect of cellular transition metal ion acquisition. PMID: 24297923
    8. CCS-1 facilitates copper trafficking to the mitochondria, but does not affect the transfer of copper to the cytochrome c oxidase. PMID: 23900152
    9. The CCS mutation, p.Arg163Trp, causes reduced SOD1 activity and may impair other mechanisms important for normal Cu homeostasis. PMID: 22508683
    10. analysis of human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS) PMID: 22869735
    11. Loss of copper chaperone for superoxide dismutase (CCS) increases amyloid-beta production in both CCS knockout neurons and CCS small-interfering (si)RNA-treated cultured tumor cells. PMID: 20693630
    12. The results of the present study reveal the plasticity of this multi-domain chaperone in solution and are consistent with an indispensable flexibility necessary for executing its dual functions of metal binding and transfer. PMID: 21722094
    13. CCS reduces, under non-oxidative conditions, yet facilitates in the presence of H(2)O(2), mitochondrial translocation of inactive SOD1 mutants. PMID: 21354101
    14. Results describe the identification of the copper chaperone for superoxide dismutase as a mediator of copper delivery to XIAP in cells. PMID: 20154138
    15. No causative mutations for amyotrophic lateral sclerosis (ALS) gene have been detected in the CCS gene in 20 sporadic ALS patients analyzed, but an intragenic single nucleotide polymorphism has been identified. PMID: 11991808
    16. Study of site-directed cysteine-to-serine mutants of CCS suggests the formation of a domain III copper cluster within a dimeric or tetrameric protein and further suggest that this cluster may be an important element of CCS copper transfer machinery. PMID: 15736924
    17. The copper chaperone CCS is responsible for copper insertion into apo-superoxide dismutasse 1. PMID: 16132821
    18. A mechanism determining the abundance of CCS that is competitive with the process of copper delivery to SOD1 is described, revealing a unique post-translational component of intracellular copper homeostasis. PMID: 16531609
    19. copper chaperone mRNA levels were reduced in peripheral mononuclear cells after copper supplementation PMID: 17683925
    20. Measurements of hCCS-induced SOD1 activation were used to show that the C-terminal CXC sequence is both necessary and sufficient for EZn-SOD maturation. PMID: 18393442
    21. copper chaperone for SOD1 (CCS) facilitates maturation of SOD1 and that CCS overexpression ameliorates intracellular aggregation of mutant SOD1 in vivo. PMID: 18552350
    22. data suggest that Cys residues in domain 2 of hCCS are involved in the formation, stability, and redox potential of the domain 3 cluster PMID: 19007184
    23. Incomplete posttranslational modification of nascent superoxide dismutase (SOD)1 polypeptides via trasnsgenic SOD1 copper chaperone (CCS) may be a characteristic shared by familial SOD1 mutants in amyotrophic lateral sclerosis. PMID: 19227972

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Cu-Zn superoxide dismutase family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 1613

    OMIM: 603864

    KEGG: hsa:9973

    STRING: 9606.ENSP00000436318

    UniGene: Hs.502917



主站蜘蛛池模板: 无码高潮少妇毛多水多水| 四虎亚洲欧美成人网站| 亚洲大色堂人在线无码| 国产精品久久国产精麻豆99网站| 手机看片久久国产免费| 国产成人久久精品二区三区| 亚洲综合无码一区二区三区| 欧美高清性色生活片免费观看| 在线观看潮喷失禁大喷水无码| 精品亚洲国产成人av不卡| 亚洲色www永久网站| 边啃奶头边躁狠狠躁| 四虎影视88aa久久人妻| 一本一道色欲综合网| 麻豆国产精成人品观看免费| 欧美肥妇bwbwbwbxx| 国内精品伊人久久久久777| 国产毛片精品av一区二区| 日产欧美国产日韩精品| 顶级欧美做受xxx000| 国产真实夫妇视频| 亚洲精品~无码抽插| 中文字幕婷婷日韩欧美亚洲| 日韩免费无砖专区2020狼| 国产精品av在线| 少妇人妻综合久久中文字幕| 成年无码av片在线免缓冲| 精品免费看国产一区二区| 亚洲人成网网址在线看| 久久天天躁狠狠躁夜夜av| 国产精品黄页免费高清在线观看| 中美日韩毛片免费播放| 久久精品视频在线看| 国产特级毛片aaaaaa高潮流水| 国产互换人妻hd| 国产婷婷精品av在线| 亚洲人成在线观看网站无码| 国产福利视频在线观看| 国产成人综合久久久久久| 国产欧美另类精品久久久| 亚洲肥老太bbw中国熟女|