在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CCS Antibody

  • 中文名稱:
    CCS兔多克隆抗體
  • 貨號:
    CSB-PA297584
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from Jurkat cells and 3T3 cells, using CCS antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CCS Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CCS
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from C-terminal of Human CCS.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Delivers copper to copper zinc superoxide dismutase (SOD1).
  • 基因功能參考文獻:
    1. In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (i.e. CCS) and cytochrome c oxidase in mitochondria (i.e. Cox17). [review] PMID: 26745464
    2. Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro PMID: 25673218
    3. Coexpression of hCCS in the presence of copper restores the correct maturation of the SOD1 mutants and prevents the formation of the unstructured species, confirming that hCCS also acts as a molecular chaperone. PMID: 25429517
    4. CCS mRNA and protein levels in the serum are not correlated with inflammatory processes. PMID: 24855044
    5. CTR1 silencing increased the protein levels of copper chaperone ATOX1 and copper chaperone for superoxide dismutase 1 (CCS-1), but decreased copper chaperone for cytochrome c oxidase (COX17). PMID: 24343031
    6. CCS1 serves as a specialized import receptor in mitochondria that facilitates the import and folding of SOD1 and CCS1. PMID: 24026195
    7. CCS-dependent copper acquisition and distribution largely occur at membrane interfaces and that this emerging role of the bilayer may reflect a general mechanistic aspect of cellular transition metal ion acquisition. PMID: 24297923
    8. CCS-1 facilitates copper trafficking to the mitochondria, but does not affect the transfer of copper to the cytochrome c oxidase. PMID: 23900152
    9. The CCS mutation, p.Arg163Trp, causes reduced SOD1 activity and may impair other mechanisms important for normal Cu homeostasis. PMID: 22508683
    10. analysis of human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS) PMID: 22869735
    11. Loss of copper chaperone for superoxide dismutase (CCS) increases amyloid-beta production in both CCS knockout neurons and CCS small-interfering (si)RNA-treated cultured tumor cells. PMID: 20693630
    12. The results of the present study reveal the plasticity of this multi-domain chaperone in solution and are consistent with an indispensable flexibility necessary for executing its dual functions of metal binding and transfer. PMID: 21722094
    13. CCS reduces, under non-oxidative conditions, yet facilitates in the presence of H(2)O(2), mitochondrial translocation of inactive SOD1 mutants. PMID: 21354101
    14. Results describe the identification of the copper chaperone for superoxide dismutase as a mediator of copper delivery to XIAP in cells. PMID: 20154138
    15. No causative mutations for amyotrophic lateral sclerosis (ALS) gene have been detected in the CCS gene in 20 sporadic ALS patients analyzed, but an intragenic single nucleotide polymorphism has been identified. PMID: 11991808
    16. Study of site-directed cysteine-to-serine mutants of CCS suggests the formation of a domain III copper cluster within a dimeric or tetrameric protein and further suggest that this cluster may be an important element of CCS copper transfer machinery. PMID: 15736924
    17. The copper chaperone CCS is responsible for copper insertion into apo-superoxide dismutasse 1. PMID: 16132821
    18. A mechanism determining the abundance of CCS that is competitive with the process of copper delivery to SOD1 is described, revealing a unique post-translational component of intracellular copper homeostasis. PMID: 16531609
    19. copper chaperone mRNA levels were reduced in peripheral mononuclear cells after copper supplementation PMID: 17683925
    20. Measurements of hCCS-induced SOD1 activation were used to show that the C-terminal CXC sequence is both necessary and sufficient for EZn-SOD maturation. PMID: 18393442
    21. copper chaperone for SOD1 (CCS) facilitates maturation of SOD1 and that CCS overexpression ameliorates intracellular aggregation of mutant SOD1 in vivo. PMID: 18552350
    22. data suggest that Cys residues in domain 2 of hCCS are involved in the formation, stability, and redox potential of the domain 3 cluster PMID: 19007184
    23. Incomplete posttranslational modification of nascent superoxide dismutase (SOD)1 polypeptides via trasnsgenic SOD1 copper chaperone (CCS) may be a characteristic shared by familial SOD1 mutants in amyotrophic lateral sclerosis. PMID: 19227972

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Cu-Zn superoxide dismutase family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 1613

    OMIM: 603864

    KEGG: hsa:9973

    STRING: 9606.ENSP00000436318

    UniGene: Hs.502917



主站蜘蛛池模板: 正在播放重口老熟女露脸 | 国产精品美女久久久久久久| www国产内插视频| 亚洲欧美偷国产日韩| 免费观看男女性高视频| 天堂中文а√在线官网| 欧美人与动人物牲交免费观看久久| 亚洲va中文字幕无码久久| 国产欧美日韩亚洲精品专区| 亚洲综合色无码| 久久久久久久久久久久久9999| 一 级做人爱全视频在线看| 国产国拍精品av在线观看| 欧美成人精品午夜免费影视| 人妻少妇av中文字幕乱码| 亚洲乱亚洲乱少妇无码99p| 国产voyeur精品偷窥222| 精品亚洲成av人在线观看| 1000部夫妻午夜免费| 一二三四在线观看免费视频| 国产美女爽到喷出水来视频| 五 月 丁 香 综合中文| 亚洲国产中文在线二区三区免 | 久久日本三级韩国三级| 2021最新国产在线人成| 亚洲线精品一区二区三区影音先锋 | 中文字幕无码热在线视频| 国产无遮挡18禁无码网站免费| 内射无码专区久久亚洲| 18禁黄网站禁片免费观看国产| 中国少妇videos呻吟| 男女性高爱潮免费网站| 夜夜躁狠狠躁2021| 女m羞辱调教视频网站| 尤物tv国产精品看片在线| 屁屁影院ccyy备用地址| 99这里只有精品| 少妇夜夜春夜夜爽试看视频| 亚洲国产香蕉碰碰人人| 成人免费777777被爆出| 无遮挡激情视频国产在线观看|