在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CCS Antibody

  • 中文名稱:
    CCS兔多克隆抗體
  • 貨號:
    CSB-PA297584
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from Jurkat cells and 3T3 cells, using CCS antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CCS Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CCS
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from C-terminal of Human CCS.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Delivers copper to copper zinc superoxide dismutase (SOD1).
  • 基因功能參考文獻:
    1. In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (i.e. CCS) and cytochrome c oxidase in mitochondria (i.e. Cox17). [review] PMID: 26745464
    2. Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro PMID: 25673218
    3. Coexpression of hCCS in the presence of copper restores the correct maturation of the SOD1 mutants and prevents the formation of the unstructured species, confirming that hCCS also acts as a molecular chaperone. PMID: 25429517
    4. CCS mRNA and protein levels in the serum are not correlated with inflammatory processes. PMID: 24855044
    5. CTR1 silencing increased the protein levels of copper chaperone ATOX1 and copper chaperone for superoxide dismutase 1 (CCS-1), but decreased copper chaperone for cytochrome c oxidase (COX17). PMID: 24343031
    6. CCS1 serves as a specialized import receptor in mitochondria that facilitates the import and folding of SOD1 and CCS1. PMID: 24026195
    7. CCS-dependent copper acquisition and distribution largely occur at membrane interfaces and that this emerging role of the bilayer may reflect a general mechanistic aspect of cellular transition metal ion acquisition. PMID: 24297923
    8. CCS-1 facilitates copper trafficking to the mitochondria, but does not affect the transfer of copper to the cytochrome c oxidase. PMID: 23900152
    9. The CCS mutation, p.Arg163Trp, causes reduced SOD1 activity and may impair other mechanisms important for normal Cu homeostasis. PMID: 22508683
    10. analysis of human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS) PMID: 22869735
    11. Loss of copper chaperone for superoxide dismutase (CCS) increases amyloid-beta production in both CCS knockout neurons and CCS small-interfering (si)RNA-treated cultured tumor cells. PMID: 20693630
    12. The results of the present study reveal the plasticity of this multi-domain chaperone in solution and are consistent with an indispensable flexibility necessary for executing its dual functions of metal binding and transfer. PMID: 21722094
    13. CCS reduces, under non-oxidative conditions, yet facilitates in the presence of H(2)O(2), mitochondrial translocation of inactive SOD1 mutants. PMID: 21354101
    14. Results describe the identification of the copper chaperone for superoxide dismutase as a mediator of copper delivery to XIAP in cells. PMID: 20154138
    15. No causative mutations for amyotrophic lateral sclerosis (ALS) gene have been detected in the CCS gene in 20 sporadic ALS patients analyzed, but an intragenic single nucleotide polymorphism has been identified. PMID: 11991808
    16. Study of site-directed cysteine-to-serine mutants of CCS suggests the formation of a domain III copper cluster within a dimeric or tetrameric protein and further suggest that this cluster may be an important element of CCS copper transfer machinery. PMID: 15736924
    17. The copper chaperone CCS is responsible for copper insertion into apo-superoxide dismutasse 1. PMID: 16132821
    18. A mechanism determining the abundance of CCS that is competitive with the process of copper delivery to SOD1 is described, revealing a unique post-translational component of intracellular copper homeostasis. PMID: 16531609
    19. copper chaperone mRNA levels were reduced in peripheral mononuclear cells after copper supplementation PMID: 17683925
    20. Measurements of hCCS-induced SOD1 activation were used to show that the C-terminal CXC sequence is both necessary and sufficient for EZn-SOD maturation. PMID: 18393442
    21. copper chaperone for SOD1 (CCS) facilitates maturation of SOD1 and that CCS overexpression ameliorates intracellular aggregation of mutant SOD1 in vivo. PMID: 18552350
    22. data suggest that Cys residues in domain 2 of hCCS are involved in the formation, stability, and redox potential of the domain 3 cluster PMID: 19007184
    23. Incomplete posttranslational modification of nascent superoxide dismutase (SOD)1 polypeptides via trasnsgenic SOD1 copper chaperone (CCS) may be a characteristic shared by familial SOD1 mutants in amyotrophic lateral sclerosis. PMID: 19227972

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Cu-Zn superoxide dismutase family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 1613

    OMIM: 603864

    KEGG: hsa:9973

    STRING: 9606.ENSP00000436318

    UniGene: Hs.502917



主站蜘蛛池模板: 国产又粗又硬又大爽黄老大爷| 国产精品国语对白露脸在线播放| 日本真人边吃奶边做爽动态图| 亚洲天天做日日做天天欢毛片 | 国内自拍五区| 一本色道久久hezyo无码| 真实国产乱子伦对白视频不卡| 黑人强伦姧人妻久久| 丰满白嫩人妻中出无码| 无码av免费一区二区三区| av大片在线无码永久免费| 成人a大片在线观看| 久久精品成人亚洲另类欧美| 亚洲精品久久无码av片| 成人国产网站v片免费观看| 日韩a人毛片精品无人区乱码| 欧洲无码一区二区三区在线观看| 亚洲中文字幕久久无码| 午夜婷婷精品午夜无码a片影院 | 日本二区三区欧美亚洲国| 精品人妻av区乱码| 欧美 亚洲 国产 日韩 综aⅴ | 久久99亚洲精品久久99果| 欧美激欧美啪啪片免费看| 人妻老妇乱子伦精品无码专区| 国产精品无码一区二区三区在 | 亚洲熟女av乱码在线观看漫画| 国产极品视觉盛宴| 国产伦子系列沙发午睡| 亚洲国产精品久久久久4婷婷 | 色偷偷亚洲男人本色 | 亚洲色国产欧美日韩| 中国丰满熟妇xxxx性| 野花社区在线www日本| 别揉我奶头~嗯~啊~一区二区三区 免费不卡无码av在线观看 | 性生交大全免费看| 亚洲国产av天码精品果冻传媒| 亚洲男人的天堂在线aⅴ视频| 一本大道久久久久精品嫩草| 免费无码久久成人影片| 日本三级带日本三级带黄|