在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CCS Antibody

CCS Antibody

  • 中文名稱：
    CCS兔多克隆抗體
  • 貨號：
    CSB-PA292985
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA292985(CCS Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA292985(CCS Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: 293T cells, hepg2 cells, human fetal liver tissue, Primary antibody: CSB-PA292985(CCS Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CCS
  • 別名：
    CCS antibody; CCS_HUMAN antibody; Copper chaperone for superoxide dismutase antibody; MGC138260 antibody; SOD 4 antibody; SOD4 antibody; Superoxide dismutase copper chaperone antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human CCS
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Delivers copper to copper zinc superoxide dismutase (SOD1).
  • 基因功能參考文獻：
    1. In addition to Atox1, the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (i.e. CCS) and cytochrome c oxidase in mitochondria (i.e. Cox17). [review] PMID: 26745464
    2. Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro PMID: 25673218
    3. Coexpression of hCCS in the presence of copper restores the correct maturation of the SOD1 mutants and prevents the formation of the unstructured species, confirming that hCCS also acts as a molecular chaperone. PMID: 25429517
    4. CCS mRNA and protein levels in the serum are not correlated with inflammatory processes. PMID: 24855044
    5. CTR1 silencing increased the protein levels of copper chaperone ATOX1 and copper chaperone for superoxide dismutase 1 (CCS-1), but decreased copper chaperone for cytochrome c oxidase (COX17). PMID: 24343031
    6. CCS1 serves as a specialized import receptor in mitochondria that facilitates the import and folding of SOD1 and CCS1. PMID: 24026195
    7. CCS-dependent copper acquisition and distribution largely occur at membrane interfaces and that this emerging role of the bilayer may reflect a general mechanistic aspect of cellular transition metal ion acquisition. PMID: 24297923
    8. CCS-1 facilitates copper trafficking to the mitochondria, but does not affect the transfer of copper to the cytochrome c oxidase. PMID: 23900152
    9. The CCS mutation, p.Arg163Trp, causes reduced SOD1 activity and may impair other mechanisms important for normal Cu homeostasis. PMID: 22508683
    10. analysis of human superoxide dismutase 1 (hSOD1) maturation through interaction with human copper chaperone for SOD1 (hCCS) PMID: 22869735
    11. Loss of copper chaperone for superoxide dismutase (CCS) increases amyloid-beta production in both CCS knockout neurons and CCS small-interfering (si)RNA-treated cultured tumor cells. PMID: 20693630
    12. The results of the present study reveal the plasticity of this multi-domain chaperone in solution and are consistent with an indispensable flexibility necessary for executing its dual functions of metal binding and transfer. PMID: 21722094
    13. CCS reduces, under non-oxidative conditions, yet facilitates in the presence of H(2)O(2), mitochondrial translocation of inactive SOD1 mutants. PMID: 21354101
    14. Results describe the identification of the copper chaperone for superoxide dismutase as a mediator of copper delivery to XIAP in cells. PMID: 20154138
    15. No causative mutations for amyotrophic lateral sclerosis (ALS) gene have been detected in the CCS gene in 20 sporadic ALS patients analyzed, but an intragenic single nucleotide polymorphism has been identified. PMID: 11991808
    16. Study of site-directed cysteine-to-serine mutants of CCS suggests the formation of a domain III copper cluster within a dimeric or tetrameric protein and further suggest that this cluster may be an important element of CCS copper transfer machinery. PMID: 15736924
    17. The copper chaperone CCS is responsible for copper insertion into apo-superoxide dismutasse 1. PMID: 16132821
    18. A mechanism determining the abundance of CCS that is competitive with the process of copper delivery to SOD1 is described, revealing a unique post-translational component of intracellular copper homeostasis. PMID: 16531609
    19. copper chaperone mRNA levels were reduced in peripheral mononuclear cells after copper supplementation PMID: 17683925
    20. Measurements of hCCS-induced SOD1 activation were used to show that the C-terminal CXC sequence is both necessary and sufficient for EZn-SOD maturation. PMID: 18393442
    21. copper chaperone for SOD1 (CCS) facilitates maturation of SOD1 and that CCS overexpression ameliorates intracellular aggregation of mutant SOD1 in vivo. PMID: 18552350
    22. data suggest that Cys residues in domain 2 of hCCS are involved in the formation, stability, and redox potential of the domain 3 cluster PMID: 19007184
    23. Incomplete posttranslational modification of nascent superoxide dismutase (SOD)1 polypeptides via trasnsgenic SOD1 copper chaperone (CCS) may be a characteristic shared by familial SOD1 mutants in amyotrophic lateral sclerosis. PMID: 19227972

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cu-Zn superoxide dismutase family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1613

    OMIM: 603864

    KEGG: hsa:9973

    STRING: 9606.ENSP00000436318

    UniGene: Hs.502917



主站蜘蛛池模板： 天堂va欧美ⅴa亚洲va| 亚洲 日韩 国产 中文有码| 最新国产aⅴ精品无码| 国产色情又大又粗又黄的电影| 成熟妇人a片免费看网站| 人妻人人做人做人人爱| 国产午夜精品一区二区三区老| 亚洲自偷自拍另类12p| 成人免费无码大片a毛片| 亚洲 中文 欧美 日韩 在线| 无码专区―va亚洲v专区在线| 成人免费播放视频777777| 国产成人无码a区精油按摩| 偷看少妇自慰xxxx| 欧美精品videossex另类日本| 一本无码中文字幕在线观| 国产偷窥熟女精品视频| 国产精品无码久久久久久久久久 | 在线看亚洲十八禁网站| 国产成人综合色在线观看网站 | 乌克兰美女浓毛bbw| 亚洲国产精华液网站w| 强奷乱码中文字幕熟女导航| 久久精品国产福利一区二区 | 中国国产1级毛卡片| 真实的国产乱xxxx| 久久视频在线视频| 日日噜噜大屁股熟妇| 人妻精品动漫h无码中字| 日韩精品一区二区三区免费视频| 国产高潮抽搐喷水高清| 国产亚洲色欲色一色www| 中文无码乱人伦中文视频在线v| 中文成人无码精品久久久不卡| 亚洲精品中文字幕久久久久下载| 大黑人交xxxx18视频| 成人性生交大片免费看vr| 成年无码av片在线免缓冲| 99久久99久久免费精品蜜桃 | 亚洲成αv人片在线观看| 国产sm重味一区二区三区|